@fillouxlab.bsky.social
Happy to share our recent story on the Type VII secretion system. Here were present new insights into the regulation of secretion mediated by the central pore. Thanks to all authors involved in the work. 🙂
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 5d agoIntrinsic flexibility of Type VII secretion central pore is required for substrate translocation https://www.biorxiv.org/content/10.64898/2026.07.31.742005v1
Headed to #mmpc2026 in Minneapolis this year? Order your MMPC t-shirt before Septemeber 4th! Fun fact: I went through a previous MMPC abstract book and counted all the unique microbes. Can you see your favorite microbe in the shirt design?
Midwest Microbial Pathogenesis Conference@mmpconference.bsky.social · yesterdayNew for #mmpc2026 this year: T-SHIRTS!! Designed by @ruthlessruth15.bsky.social & featuring your favorite microbes! Shirts must be ordered by Sept 4 & can be picked up at the conference. Get your official 2026 Midwest Microbial Pathogenesis Conference swag here: mmpc2026.umn.edu/more/2026-mm...
I'm excited to be co-organizing the 2026 Midwest Microbial Pathogenesis Conference, which will take place Sept 25-27 on the UMN campus in Minneapolis! Poster abstracts due Aug 7! Submit yours & register here ➡️ mmpc2026.umn.edu
Registration | Midwest Microbial Pathogenesis Conference 2026
mmpc2026.umn.edu
Preprint 🦠🚨: We are diving deeper into #T6SS effectors, and now in #Pantoea. We describe the largest, most diverse effector arsenal associated with a single T6SS, and it's in a plant pathogen that forms galls on beet roots. Sweet! 1/8 www.biorxiv.org/content/10.6...
Pantoea agglomerans T6SS effectors reside in hotspots with combinatorial offensive and defensive arsenals
Gram-negative bacteria deploy type VI secretion systems (T6SSs) to mediate interbacterial competition. Although numerous T6SS effectors have been identified, their pan-genomic repertoires and evolutio...
biorxiv.org
Abstract submissions are closing for the Microbiology Society Annual Meeting in Ireland 2026. Submit by 4 August 2026: https://microb.io/3TCU0Sg. #MicrobioIrish26
FEMS MICRO 2027 – Growing Microbial Futures ✨ Explore Ljubljana & the venue ✨ Submit a session proposal ✨ Save the date Be part of the conversations shaping the future of microbiology. Join us in Ljubljana next July and stay updated: buff.ly/5HEuk3g
🧬🦠 Environmental #Bacteria can transfer #genes that enhance survival and adaptation, offering new insights into #microbial #evolution and the spread of important traits. #Microbiology #GeneTransfer #Genetics #Microsky via @sciencex.bsky.social
Environmental bacteria ferry genes that boost antibiotic resistance over 10,000-fold
A patient with a severe infection is prescribed a potent antibiotic. Hopes for improvement are high, but just after treatment is given, resistance to the drug increases thousands of times. How could…
phys.org
www.cell.com/cell-host-mi... a first collaborative paper with @audeber.bsky.social @pasteur.fr - with more to come!
A family of lanthipeptides with anti-phage function
Shomar, Guillaume, et al. report the genomics-driven discovery of a family of more than 2,000 lanthipeptide biosynthetic gene clusters with anti-phage potential. They experimentally demonstrate anti-p...
cell.com
Salmonella effector kinase SteC is activated by phosphorylation at Serine 379 dx.plos.org/10.1371/jour...
Salmonella effector kinase SteC is activated by phosphorylation at Serine 379
Author summary Salmonella is a bacterium that causes a wide range of human diseases, from gastroenteritis to systemic infection. Blood stream infections are more common in young children or those who ...
dx.plos.org
Dear microbiome enthusiasts: I'm excited to be moving my lab to New York University this fall (& the NYU Institute for Engineering Health); with joint-appointment @isbscience.org I'm hiring a postdoc @ NYU to look at diet-driven evolution in the gut: apply.interfolio.com/189980 Please share! 🦠🤓
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
Some bacteria use the CRISPR/Cas systems as transcriptional repressors of other anti-phage systems, such that when CRISPR interfered with, gene expression of repressed anti-phage systems goes up www.nature.com/articles/s41...
CRISPR–Cas regulates expression of embedded anti-phage defence systems - Nature
CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establis...
nature.com
One more race completed. This one quite a challenge, La Restonica by UTMB in Corsica, 17K 650mD+
New in JB: Milcarz, Zakrzewska-Czerwińska et al. describe a N-terminal domain of FtsK, conserved among mycobacteria, that plays a key role in asymmetric cell division, likely via interacting with specific proteins & membrane lipids. @asm.org #JBacteriol #MicroSky journals.asm.org/doi/10.1128/...
Scientists from SCELSE, NTU Singapore and Imperial College London have uncovered a previously unknown step in how Pseudomonas aeruginosa loads toxins into its microscopic T6SS weapon before attack. Watch the video below on this research published in Nature Microbiology. @fillouxlab.bsky.social
One of these brilliant minds is my dear friend and collaborator, @davidalbesa.bsky.social He got an ERC Advanced Grant to advance his work on T6SS pore-forming toxins. I can't wait to see the incredible science he will do. So incredibly well deserved. A thousand congratulations, David! 🥳 🥳 🥳
European Research Council (ERC)@erc.europa.eu · last mo.The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch
Thanks to my lab for the b'day cake🎂 & gifts!🥰 Aperol🍹+chocolate🍫(they know me way too well!)-plus promising new data🤓 Tuesday was also my last day before rotating off my Institute Directorship, so hopefully more time back at the bench... assuming turning 5️⃣0️⃣ doesn't immediately come with back pain 😂
Walk through our July issue! Read about 💊Microbiome and AMR 🧊Permafrost microbes 🦠Phages and flagella ⚕️Cholera protection 💉Poxvirus vaccine design 🍄Commensal skin yeast and much more! www.nature.com/nmicrobiol/v... #MicroSky
A secreted endosymbiont protein essential for colonizing host cells www.nature.com/articles/s41...
A secreted endosymbiont protein essential for colonizing host cells - Nature
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
nature.com
Pathogens have spent millions of years learning how to hijack human cells. Now, researchers from the Stark lab at the IMP and the Taipale lab at the Donnelly Centre, University of Toronto, have built a platform to systematically discover how they do it:
Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky
Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning
Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.
go.nature.com
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC @kedrov-lab.bsky.social, Roland Beckmann and coworkers link.springer.com/article/10.1...
Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC - The EMBO Journal
The Sec translocon and the YidC/Oxa1-type insertases universally mediate biogenesis of α-helical membrane proteins, but the molecular basis of their cooperation has remained disputed. Recent discovery...
link.springer.com
How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...
🚨New paper alert 🚨 Here we tried to leverage an (incredible) metagenome time-series to better understand MGE diversity and activity in soil across decade(s). @scbagby.bsky.social has an amazing thread about this work with all the details - bsky.app/profile/scba...
Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils - Nature Microbiology
An 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.
nature.com
Sarah Bagby@scbagby.bsky.social · last mo.Out today in Nature Microbiology: a paper that started in 2021 with an email from @sullivan-lab.bsky.social. Subject line: "Crazy ideas". www.nature.com/articles/s41... 1/23
📢 We're hiring! The Department of Microbiology & Cell Biology at Montana State University is hiring an Assistant Professor of Microbiology. We welcome applicants working in microbial pathogenesis, immunology, genetics, microbial evolution, and related areas. Apply: jobs.montana.edu/postings/52009
The @fillouxlab.bsky.social is growing and having fun. Very pleased to have such a nice @scelse.bsky.social group in Singapore @NTU and working on #T6SS #Biofilm #c-di-GMP #Pseudomonas #antibiotics. So let's refresh the pinned group's photo with this one.
Scientists have used a machine-learning strategy to discover antibiotics with fresh mechanisms go.nature.com/4g2O4eD
AI tool spots antibiotics that fight drug-resistant gonorrhoea
Nature - The bacterium Neisseria gonorrhoeae has evolved resistance to most antibiotics used to treat it, but a machine-learning screen reveals potential therapies.
go.nature.com
New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.
Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
rdcu.be
