RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

A few days ago, we escaped the heat of Freiburg and enjoyed a little Lab hike in the Black Forest!😎🥾🌳 Waterfalls (or what’s left of it🙄), suspension bridge and a classic mountain coaster🎢🤩 A great opportunity to build lab spirit - and a lot of fun!🥳

📣 #JobAlert The Faculty of Biology of @uni-freiburg.de invites applications for a Professorship (W3) for Bioinformatics and Molecular Genetics. ❗ Application Deadline: 15 August, 2026 🔗 kurzlinks.de/roi8 #Biology #Bioinformatics #MolecularGenetics

We are over the moon! 🎈 Dr. Marieke Oudelaar joins the MPI-IE as a new #MaxPlanck Director, heading the newly established Department of Genome Biology She studies how the 3D folding of DNA controls gene expression – more details below ⬇️ Welcome to #Freiburg, @mariekeoudelaar.bsky.social!

Marieke Oudelaar becomes new Director at MPI-IE in Freiburg

ie-freiburg.mpg.de

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Delighted to share our lab's latest (w/ inimitable @genophoria.bsky.social) in final form at @nature.com. Enormous lift by Sean Wang, @palindromephd.bsky.social & @martyyang.bsky.social to address extensive & constructive reviewer comments & see this through. (1/n) www.nature.com/articles/s41...

Pervasive and programmed nucleosome distortion on single chromatin fibres - Nature

An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome types and shows that most nucleosomes exhibit programmed ‘di...

nature.com

Reminder: PhD position in my lab is open for two more weeks. How do germ cells use their own private transcription factors? Come help us find out. Fully funded. Deadline May 1. Flyer attached — please boost! 🙏

Peter Andersen@germline.bsky.social · 4mo ago

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

🚨 Postdoc in 3D genome architecture – join the @jumanaaha.bsky.social lab at the MPI-IE, Freiburg (🇩🇪) The wonderful lab of Jumana AlHaj Abed is pushing the limits of how chromosomes fold and interaction – and we need someone who can code, image, & think across scales. Apply here: s.gwdg.de/9c8838

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you! 1/n

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Biological Laboratory | LEGO® Ideas

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

beta.ideas.lego.com

Fantastic news before we enter the weekend. @nanodiagbw.bsky.social receives funding approval! The »cluster4future« receives 15 Mio. € for their next phase making nanopore technology usable for the molecular diagnostics. Great success. Our proteomics facility is part of the cluster. 😍

nanodiag BW receives funding for second implementation phase - nanodiag BW

Nanopore technology for next-generation molecular diagnostics: Freiburg innovation network continues development toward clinical application

nanodiag.de

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication

Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

rdcu.be

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more… Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de? This is your timeline. Apply by February 6th, 2026 www.ie-freiburg.mpg.de/apply-imprs-...

Stress controls epigenetic inheritance! A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer 👉 nature.com/articles/s41586-025-09899-8

Happy New Year!🎉 We hope everyone has enjoyed the holidays! If you have an exciting chromatin/transcription story, or if you know someone with one, please fill out the form or get in contact with us! 😉 forms.gle/TBi38UgYxPAB...

Application to speak in the Fragile Nucleosome series

Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

forms.gle

FragileNucleosome@fnucleosome.bsky.social · 8mo ago

Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community? Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB... Please repost and share!

Still time to apply until January, 19th!

Kerstin Göpfrich@kgoepfrich.bsky.social · 8mo ago

We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!

Congrats to the team for such creative craft - first time winner of the Christmas Wreath-Off at @mpi-ie.bsky.social!🥳

Muskan Gupta@muskang.bsky.social · 8mo ago

Science off the bench! 🥳 Here's to our beautiful Christmas wreath — creatively adorned with colorful Falcon caps, mini Eppis, and, of course, our signature artistic yeast plates. 😎🎨

Happy holidays from the @flurylab.bsky.social!🎉 A year with a lot of firsts: first PhD students, first Postdoc, first grant & first farewells - and a first lab move, too! Thanks to my amazing team for the hard work & curiosity!💪🧐👥 Can't wait to tackle more firsts (& seconds) in the coming year(s)!🙌🤩

Our PhD program IMPRS-EBM of #Epigenetics, #Biophysics & #Metabolism will open for applications next week. 📢 Want to work at the forefront of epigenetic research at an MPI? Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...

This Thursday, we’re pleased to welcome Philipp Korber. Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning. Join us!

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team! Please repost! jobs.jic.ac.uk/Details.asp?...

Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...

It has been a lot of fun to present our research focus and get to know the @gfgenetik.bsky.social! Thank you so much for having me and organising this great symposium! Looking forward to the next one!

Gesellschaft für Genetik@gfgenetik.bsky.social · 10mo ago

Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.

This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1.... This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...

biorxiv.org

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role: www.fmi.ch/education-ca...

FMI science@fmiscience.bsky.social · 11mo ago

🚨 Job Alert: we seek a Lab Manager for @juliabatki.bsky.social's new group (start Mar 2026), which will study cell fate regulation during organ development. Join the Batki's group to drive experiments & lab operations! Apply at: www.fmi.ch/education-ca...

We are hiring-join us!

FMI science@fmiscience.bsky.social · 11mo ago

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Massive congratulations to @canaztekin.bsky.social for being awarded an ERC Starting Grant @erc.europa.eu ! 🎉 His "Signal to Regeneration" (SigReg) project will explore the potential of limb regeneration in mammals. Read more and watch Can introduce his project: s.gwdg.de/cLAmJE

What a special moment!🙌🙌🙌

Juliane Glaser@julianeg.bsky.social · 11mo ago

I am also very happy to share this good news my colleague @flurylab.bsky.social @mpi-ie.bsky.social 🥂🥂