🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: SMARCAL1 is a candidate therapeutic target for ALT-positive tumors By Taglialatela et al., and Alberto Ciccia ➡️ https://ow.ly/BUA150ZoCcg Alberto Ciccia Angelo Taglialatela Columbia University #cancer #telomere #cancertherapy

Honored to see our recent work featured by the Herbert Irving Comprehensive Cancer Center!@columbiauniversity.bsky.social Congratulations to all my co-authors and collaborators on this exciting milestone! @albertociccia.bsky.social 📄 Genes & Development: genesdev.cshlp.org/content/earl...

The Means to an End of Aggressive Tumors

A project led by Columbia University scientists has revealed a key weakness in some of the most aggressive and treatment-resistant cancers, including gliomas and pediatric sarcomas.

cancer.columbia.edu

Our manuscript on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1 is finally out in @genesdev.bsky.social. Big thanks again to the Min, Lazzerini Denchi and @cejkalab.bsky.social labs! @angelotaglialatela.bsky.social genesdev.cshlp.org/content/earl...

Alberto Ciccia@albertociccia.bsky.social · 6mo ago

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Happy to share ProTiler-Mut, a computational framework that leverages CRISPR tiling screens to map protein mutation–phenotype relationships, developed by Wei He and @hanxu-mdacc.bsky.social in collaboration with @raphguerois.bsky.social and our group. authors.elsevier.com/c/1nKys_siQz...

Happy to share ProTiler-Mut, a computational framework that leverages CRISPR tiling screens to map protein mutation–phenotype relationships, developed by Wei He and @hanxu-mdacc.bsky.social in collaboration with @raphguerois.bsky.social and our group. authors.elsevier.com/c/1nKys_siQz...

Everyone in our field needs to stop what they are doing and read this magnificent work of ART & KNOWLEDGE that just dropped!

Alberto Ciccia@albertociccia.bsky.social · 2mo ago

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research/pro...

Another classic from @albertociccia.bsky.social & @angelotaglialatela.bsky.social!

Alberto Ciccia@albertociccia.bsky.social · 3mo ago

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

annualreviews.org

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL #ASH25 | @ash.hematology.org

❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC). No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403 Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...

New York Times article on science funding with some depressing but familiar curves with interactive graphics. www.nytimes.com/interactive/...

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article)

A quiet policy change means the government is making fewer bets on long-term science.

nytimes.com

The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecru...

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

In a medical breakthrough, a team including IGI’s @urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months. Read more: ow.ly/G0Bg50VTonC #RareDisease 🧬

Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!

Thanks to all the attendees of the Keystone Symposium on DNA Replication Gaps, Cancer, and Disease for a fantastic meeting! @cantorlab.bsky.social @labvincenzo.bsky.social

Cantorlab@cantorlab.bsky.social · last yr.

Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together! @albertociccia.bsky.social @labvincenzo.bsky.social

Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

Congratulations to the 2025 Canada Gairdner Award laureates! This year’s laureates represent some of the world’s most significant biomedical and global health research and discoveries. Learn more about their award-winning research here: gairdner.org/resource-hub... #GairdnerAwards

I'm happy to share that I've joined @ifomresearch.bsky.social as a Junior Group Leader, leading the Functional Genomics of Cancer Immunity Laboratory! 🔬 The lab investigates the links between DNA damage response (DDR) and cancer immunity. Exciting times are ahead—stay tuned!

Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25. youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social

KSQA: Dr. Kyungjae Myung (DNA Replication Gaps)

YouTube video by KeystoneSymposia

youtu.be

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

Excellent Info Graphic. Share everywhere!

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ@nizet.bsky.social · last yr.

Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk. www.keystonesymposia.org/conferences/...