Plenary talk at #FENS2026! @fens.org And my soundtrack for the conference was "Dancing with the Europeans" from @suedehq.bsky.social, who gave a fenomenal concert at the Cruilla festival in Barcelona! youtu.be/PCNdb5zlQLE?...
Gonçalo Castelo-Branco
@gocastelobranco.bsky.social
Professor of Glial Cell Biology @ Karolinska Institutet, Stockholm, Sweden • epigenomics • single-cell • spatial • oligodendrocytes • myelin • multiple sclerosis • 🎧 Hannes • https://ki.se/en/people/goncalo-castelo-branco
Great and truly inspiring plenary lecture by @gocastelobranco.bsky.social at FENS2026 in Barcelona, on a dense and long journey through oligo and MS @ki.se
Join us at the 13th Developing Brains, October 7th, Nobel Forum @ki.se! Register at news.ki.se/calendar/dev... with @anderssonlab.bsky.social @sarabiz86.bsky.social @andreabrandlab.bsky.social among other! @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social
Please RP! Excited to share our new preprint: “Single-cell chromatin tracing reveals multimodal molecular programs during memory formation” We built a single-cell multiomic atlas of aversive learning and used it to trace memory-linked molecular programs. doi.org/10.64898/202...
Come and start your group at @ki.se! ki.se/en/about-ki/...
Assistant Professor recruitment programme 2026
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
ki.se
What happens to the brain after focal myelin loss? Our new paper, published today in @nature.com tries to answer this question: go.nature.com/3Qgd47r Details in the 🧵 (1/8)
go.nature.com
Nature research paper: Focal white matter lesions drive grey matter inflammation and synapse loss go.nature.com/3Qgd47r
Focal white matter lesions drive grey matter inflammation and synapse loss - Nature
A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.
go.nature.com
New atlas shows how adult brain cells retain traces of their development. 🧪 “For this #SingleCell #epigenomic mapping of the human brain, extensive #DNAsequencing was required,” says @gocastelobranco.bsky.social More here ↓ www.scilifelab.se/news/new-atl...
New atlas shows how adult brain cells retain traces of their development
A new study from Karolinska Institutet and SciLifeLab presents a detailed map of how gene activity is regulated in individual cells of the adult human brain and spinal cord. Published in Nature Neuros...
scilifelab.se
KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...
New map reveals how adult brain cells remember their origins
Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...
news.ki.se
Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 6mo agoOur latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...
Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs - Nature Neuroscience
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
nature.com
Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?...
Google Search
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chrismlangseth.bsky.social@chrismlangseth.bsky.social · 6mo agoLet me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...
Congrats @patrikernfors.bsky.social!!! Our head of the MolNeuro unit at @ki.se, an inspiration to all of us!
The Brain Prize@brainprize.org · 6mo agoWarm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026
Registration for Single Cell Biology 2026 is now open! #SingleCell26 Join us as we explore new single cell research insights and discoveries beyond the traditional model organisms🧬 🗓️ 10-12 June 📍 Wellcome Genome Campus, UK Bursaries available 📎 bit.ly/4pyTK21 #SingleCell #Spatial #Genomics
Curling kick off 2026 of our Molecular Neurobiology unit @ki.se! @hjerling-leffler.bsky.social @onurdagliyan.bsky.social @patrikernfors.bsky.social @matzag.bsky.social @gvolkmer.bsky.social ...and many others!
A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.
This week, the #FENS-Hertie #WinterSchool 2025-2026, “Single-Cell and Spatial Omics to Understand Brain Heterogeneity”, is taking place in Alicante. 🇪🇸 🧠 Monday's programme kicked off with a session led by Bosiljka Tasic, followed by Gabriel Santpere Baró, and a roundtable discussion.
Now online! Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.
dlvr.it
My 2025 soundtrack, with the music I was listening to for our papers, preprints, etc, including Sonic Surf City's Surfing Santa (by Ola Hermanson)... for Ola. open.spotify.com/playlist/5ts... Happy Xmas and 2026!
Spotify – Web Player
open.spotify.com
SciLifeLab PULSE postdoc program, our lab can be one of the hosts!
SciLifeLab@scilifelab.se · 9mo agoOur call for 27 PULSE #postdocs is OPEN! PhD within the last 3 years looking to grow your life science career? SciLifeLab PULSE (MSCA Cofund) offers 3-year postdoc fellowships at Swedish universities with academic & industry secondments 🧪 🖥️ 🧬 📅 Apply Dec 15, 2025-Mar 16, 2026 👉 bit.ly/3MD7Pwz
Physiology or Medicine Nobel Lectures 2025 at @ki.se , with the key experiments and notes leading to the Tregs discovery!
First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS
Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...
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Margherita Zamboni@margheritazamboni.bsky.social · 9mo agoThrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com
🧬 Gonçalo Castelo-Branco | Plenary Speaker How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...
Oligodendrocytes show early changes in multiple sclerosis
A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...
news.ki.se
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com! Check it out at: www.nature.com/articles/s41... with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience
Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...
nature.com
Our latest, a tour de force from @carlstrom.bsky.social ! And here is my soundtrack for the journey, The Bike Song, by Mark Ronson and The Business Intl, dedicated to Karl's bike! youtu.be/rVELTxKRoHA?...
Mark Ronson, The Business Intl. - The Bike Song (Official Video)
YouTube video by MarkRonsonVEVO
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Join us for the inaugural annual Ernest Arenas Memorial Lecture at the Nobel Forum at @ki.se. with Prof. Roger Barker, University of Cambridge "Repairing the human brain using transplants - is it possible? The story of Parkinson's disease" Tuesday November 25th at 15:00 news.ki.se/calendar/the...
The Ernest Arenas Memorial Lecture: Repairing the human brain using transplants- Is it possible? The story of Parkinson's disease.
Welcome to The Ernest Arenas Memorial Lecture with Professor Roger Barker, Professor of Clinical Neuroscience at the University of Cambridge and Consultant Neurologist at Addenbrooke's Hospital.
news.ki.se
Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience @gocastelobranco.bsky.social news.ki.se/scientists-m...
Scientists map how the brain develops – and how it resolves inflammation
Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...
news.ki.se
Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...
Scientists map how the brain develops – and how it resolves inflammation
Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...
news.ki.se
Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 10mo agoOur latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...