Atlas of cell types and regulatory elements underlying human facial diversity - Nature Genetics

Single-cell transcriptomics, spatial transcriptomics and chromatin accessibility maps of the human craniofacial region in developing embryos provide insights into the mechanisms underlying facial vari...

nature.com

su.se

Twenty-two easy ways to power up your lab meetings

Scientists share help and advice on how they got their research discussions flowing.

nature.com

Alternate RNA decoding results in stable and abundant proteins in mammals - Nature

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and dise...

nature.com

A Hierarchical Molecular Scaffold for Vestibular Circuit Organization

The vestibular system is essential for balance, posture, gaze stabilization, and spatial orientation, yet lacks the molecular framework that has transformed understanding of other sensory systems. By ...

doi.org

The intrinsic cardiac nervous system is essential for cardiac function and survival

Two genetically distinct neuronal subtypes in the intrinsic cardiac nervous system are differentially required for baseline cardiac function and stress resilience to maintain cardiac stability and sur...

cell.com

Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage - Nature Communications

Neural crest cells differentiate into skeletogenic mesenchyme and neuro-glial lineages, thereby contributing to craniofacial formation. Here, single-cell analysis of cranial neural crest shows that sp...

nature.com

Saida Hadjab receives second Novo Nordisk Foundation grant to advance chronic pain research

Chronic pain affects millions of people worldwide, yet current treatments often only ease symptoms rather than addressing the underlying causes. Now, Karolinska Institutet researcher Saida Hadjab has ...

news.ki.se

Co-option and innovation in neural crest evolution

Neural crest evolution reassembled ancient programs in pigment cell lineage, resulting in vertebrate innovations.

science.org

4E Therapeutics Acquired by Lilly to Advance Non-Opioid Approach to Chronic Pain

/PRNewswire/ -- 4E Therapeutics, Inc. ("4E"), an Austin-based neuroscience company developing next-generation treatments for chronic pain, today announced that...

prnewswire.com

Assistant Professor recruitment programme 2026

Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...

ki.se

biorxiv.org

Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain - Nature

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

buff.ly

Conserved brain-wide emergence of emotional response from sensory experience in humans and mice

Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discovera...

science.org

15 million for research on cell therapy for Parkinson’s disease

Karolinska Institutet has received a grant of DKK 10 million (approximately SEK 15 million) from the Novo Nordisk Foundation for research on cell therapy for Parkinson’s disease. The project is led by...

news.ki.se

T-cell distribution in the dorsal root ganglion across species, sex, and age

T-cells infiltrate somatosensory ganglia in response to nerve damage, autoimmune disease, and infection, contributing to sensory abnormalities and pain. In naive states, T-cells are rare in the rodent dorsal root ganglion (DRG) but have been reported in human and non-human primates without known relevant exposures. It remains unclear whether there are inherent evolutionary or species differences in DRG T-cell residence. Using a comparative biology approach, we investigated the frequency and distribution of T-cells in the mammalian DRG across humans, non-human primates, pigs, and rodents, and in humans investigated the contributions of sex and age. Spatial transcriptomics and immunofluorescence independently verified the robust presence of DRG T-cells at similar levels in humans, non-human primates, and pigs, but were fewer in rats and largely absent in mice. In humans, premenopausal females were more likely to have elevated DRG endoneurial T-cells than post-menopausal females or adult males. T-cells were detected in human dorsal root ganglion at as early as two months of age but were less abundant within the perineuronal niche. Most human DRG T-cells expressed distinct markers consistent with a resident memory (Trm) phenotype. We discuss the importance of studying the functional roles of DRG-resident T-cells and raise broader considerations for modelling peripheral nervous system disease. ### Competing Interest Statement TJP is co-founder of 4E Therapeutics, PARMedics, NuvoNuro, Nerveli, and Ted and Gregs. National Institutes of Health, https://ror.org/01cwqze88, U19NS130608

biorxiv.org