New from our lab @crick.ac.uk. Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones. Which chaperones recognise specific nascent chains, and what dictates their binding preferences? www.biorxiv.org/content/10.6...

In recognition of their operational excellence, and the collaborative and supportive environment they have fostered within the Aston Institute for Membrane Excellence (AIME), our 2027 Research Support Award goes to Helen Elwood (Lab Manager) and Paul Knobbs (Institute Director)!

Both adverts are now out! 4- year PDRA position: lnkd.in/euijUXW4 closes 1st May. 4-year PhD position: lnkd.in/eWUsRrv4 closes 1st June. Both positions are expected to start on 1st October. Reach out for more info! @astonaime.bsky.social @leverhulme.ac.uk #membraneproteins #proteinfolding

I’m recruiting! I'm excited to share a new 4-year fully funded Leverhulme Trust PhD studentship to define the rules governing membrane protein folding. www.findaphd.com/phds/project... Advert closes 1st June for a 1st October start. Please reach out for more info! PDRA ad (4 years) to follow!

If you are a talented ECR, based outside of the UK, send us your CV. Accelerate your research career in our world class multidisciplinary research environment. AIME want to support your fellowship applications www.aston.ac.uk/research/aime @astonuniversity.bsky.social @astonaime.bsky.social

Our latest cotranslational folding story is now published @cp-molcell.bsky.social. Really cool (I think) new ideas about how exactly the ribosome directs folding and assembly to make sure complicated proteins mature efficiently in cells. www.cell.com/molecular-ce...

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Large oligomeric proteins constitute a major fraction of proteomes, but are difficult to refold in vitro, raising the question of how cells direct their biogenesis. Roeselová and Shivakumaraswamy et a...

cell.com

If anyone is interested in making bacterial ribosome-nascent chain complexes and studying them using HDX-MS, we have written up a detailed protocol. rdcu.be/eYFx4 Characterise the conformational dynamics of the ribosome, nascent polypeptide and bound chaperones, label-free and at peptide-level

New Article! Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level

Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level

Nature Protocols, Published online: 12 January 2026; doi:10.1038/s41596-025-01279-wA strategy for isolating Escherichia coli ribosome–nascent chain complexes and analyzing their conformational dynamics and interactors at peptide level using hydrogen–deuterium exchange mass spectrometry is presented.

dlvr.it

Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk. www.nature.com/articles/s41...

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications

The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...

nature.com

Biochemical Society's Membrane Protein Conference 7–9 April 2026 Birmingham, UK | Leonardo Royal Hotel - Abstracts welcome for talks & posters - Bursaries available! - Register & submit here: www.eventsforce.net/biochemsoc/f... #MembraneProteins #CallForAbstracts @biochemsoc.bsky.social

New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

Nature Structural & Molecular Biology, Published online: 19 September 2025; doi:10.1038/s41594-025-01676-5By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.

go.nature.com

Re-advertising! Closes September 1st. 💧 Interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧 If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social tinyurl.com/5dc23mu3 Reach out for details!

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com

PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

tinyurl.com

1 week to go - get your applications in!

Grant Pellowe @grantpellowe.bsky.social · last yr.

💧 Are you interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧 If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social! www.findaphd.com/phds/project... Reach out for further details!

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1

Proteins with multiple domains are intrinsically prone to misfold, yet fold efficiently during their

biorxiv.org

💧 Are you interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧 If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social! www.findaphd.com/phds/project... Reach out for further details!

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com

PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

findaphd.com