Visiting from Sydney, we were honoured to present Renae Ryan with the 2025 International Award today! Renae closed out the Membrane Proteins Conference with her fascinating insights into the twisted link between glutamate transporters and Episodic Ataxia.

Congratulations to Doryen Bubeck who was presented with the 2026 GlaxoSmithKline Award at Membrane Proteins Conference today! Doryen's research into the membrane attack complex has opened new lines of investigation into the importance of lipids in immune homeostasis

Thanks for visiting @figlegend.bsky.social. Safe travels back to Singapore.

@davidroper2.bsky.social · 4mo ago

Last Friday Phill Stansfeld & I played host to Dr Shu Sin Chng from National University of Singapore on his latest research in Gram negative bacterial membrane biogenesis, a core aspect of joint interests relevant to discovery of next generation antibiotics and combating the rise of AMR

Last Friday Phill Stansfeld & I played host to Dr Shu Sin Chng from National University of Singapore on his latest research in Gram negative bacterial membrane biogenesis, a core aspect of joint interests relevant to discovery of next generation antibiotics and combating the rise of AMR

Registration is open for the #CCPBioSim Annual Conference, 6-8 July, Bristol, UK! See: www.ccpbiosim.ac.uk/bristol2026 Delighted to be hosting the conference @bristoluni.bsky.social, with the theme "Biomolecular simulation across scales, for understanding and design" #compchem #compbio #biodesign

SAVE THE DATE! The next instalment of the long-running Bacterial and Archaeal Cell Division Conference will take place at www.marriott.com/en-us/hotels..., Italy from the 20th to 23rd of April 2027. Organisers: me, @s-lab.bsky.social, @awehenkel.bsky.social. More info soon. #MicroSky

Should be a great meeting - Link here: www.eventsforce.net/biochemsoc/f...

Lorraine Reese@lorraine-reese.bsky.social · 6mo ago

Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪

Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪

Save £100 if you book your place for Membrane Proteins Conference before 7 January 2026. Taking place on 7–9 April 2026 in Birmingham, don’t miss the chance to listen to expert researchers discussing membrane proteins in diverse biological processes. 🧪 https://ow.ly/rhHJ50XNBLI

🌟 New Tool Alert! 
We present MemPrO – a toolkit for orienting and building membrane protein systems: 
✅ Membrane protein orientation 
✅ Mixed membrane building 
✅ Double membranes & curvature 
✅ Peptidoglycan cell wall support 🔗 github.com/pstansfeld/mempro 
📖 pubs.acs.org/doi/10.1021/...

MemPrO: A Predictive Tool for Membrane Protein Orientation

Membrane proteins play a vital role in numerous cellular processes, including ion transport, intercellular communication, and antibiotic resistance. Ensuring their accurate orientation within lipid bi...

pubs.acs.org

🚨My lab is hiring a postdoc!🚨 If you’re interested in working out the mechanism and physiological impact of bacterial lipid transport processes then please apply! Job advert is here: tinyurl.com/4swddfda Get in touch by email (c.mulligan@kent.ac.uk) for informal enquiries Please repost! Thanks!

I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab The article is open access and available at: www.nature.com/articles/s41...

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria - Nature Communications

The study reveals the structure of ArnC, a membrane glycosyltransferase that modifies undecaprenyl phosphate with aminoarabinose (L-Ara4N), leading to polymyxin resistance. The structure of ArnC in tw...

nature.com

Congratulations to the entire team, including lead author Khuram Ashraf and our excellent collaborators @pstansfeld.bsky.social (and team) and Jason Kaelber. The original preprint thread with additional information is here: bsky.app/profile/vasi...

Vasileios Petrou@vasileiospetrou.bsky.social · 2y ago

Our new preprint is out! We report the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica and identify key structural elements that enable the glycosylation of bacterial lipid undecaprenyl phosphate. #membrane #protein #PetrouLab 🧵1/n https://buff.ly/3EvRyFy

Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking. A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli. dx.plos.org/10.1371/jour...

Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane

In E.coli, three of the four Type VII ABC transporter systems have been structurally characterized. This study solves cryo-EM structures of the fourth Type VII ABC system, YbbAP-TesA, and suggests tha...

dx.plos.org

Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.

Raffaele Ieva@raffaeleieva.bsky.social · 8mo ago

rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin

rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin

Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex

Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...

rdcu.be

Kat Blow has developed CCD2MD, a suite of packages for preparing co-folded outputs for MD simulations. Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too. pubs.acs.org/doi/full/10.... github.com/keb721/ccd2md

CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations

Protein–lipid interactions play a crucial role in the stability and function of membrane proteins. While experimental approaches to characterize these interactions in a native-like membrane environmen...

pubs.acs.org

Biochemical Society's Membrane Protein Conference 7–9 April 2026 Birmingham, UK | Leonardo Royal Hotel - Abstracts welcome for talks & posters - Bursaries available! - Register & submit here: www.eventsforce.net/biochemsoc/f... #MembraneProteins #CallForAbstracts @biochemsoc.bsky.social

Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉

MreB filaments in the elongasome modulate E. coli membrane curvature

MreB, a bacterial actin homolog, plays a pivotal role in defining the shape of rod-shaped bacteria by coordinating peptidoglycan synthesis during cell elongation. It forms filaments that interact with...

cell.com

@davidroper2.bsky.social · 10mo ago

Two PhD theses submitted to day from @warwicklifesci.bsky.social Kate Willett from my lab and Becca Bailey from @pstansfeld.bsky.social. Supervisor of one, internal examiner for another!

Fantastic WEHeraeus symposium at the Bad Honnef Physikzentrum, perfectly organised by @djanuliene.bsky.social and @arnemoeller.bsky.social. Thank you for the invitation.

Dovile Januliene@djanuliene.bsky.social · 11mo ago

Fascinating talk by Phil Stansfeld @pstansfeld.bsky.social - a great reminder of how beautifully #cryoEM and MD simulations complement each other! 😃 #WEHeraeusSeminar #StructuralBiology #Microscopy @arnemoeller.bsky.social

Józef Lewandowski and I have a JPIAMR-funded Postdoctoral position available. We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations. The successful applicant will be part of a larger consortium of academic and industrial partners. bit.ly/3TVs74O

Also a couple of back-to-back @natcomms.nature.com papers with @chelseabrown.bsky.social on Mycobacterial enzymes in collaboration with the Mancia lab et al.: doi.org/10.1038/s414... doi.org/10.1038/s414...

Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE - Nature Communications

Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-ino...

doi.org

New Paper with @deanelab.bsky.social: www.nature.com/articles/s41...

Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis - Nature Communications

Gangliosides are bioactive lipids important for neuronal cell function. Here, authors reveal the dynamic structure of the ganglioside synthetic enzyme B4GALNT1 and demonstrate how it inserts into memb...

nature.com

New paper out, with a contribution from Dom Gurvic and I; led by Andy Lovering and @lalouxlab.bsky.social: www.nature.com/articles/s41...

A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily

Nature Communications - This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows...

nature.com

Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...

You or someone you know interested in cell envelopes and getting a PhD? Come join me warwick.ac.uk/fac/cross_fa... or have a look at some of the other fantastic projects on offer @uni-of-warwick.bsky.social

An interesting tool that employs MD Simulations to explain lipid densities in cryo-EM maps. www.nature.com/articles/s41...

LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane pr...

Interpretation of lipid-like densities in cryo-EM structures of membrane proteins is challenging. Here authors present LipIDens, enabling molecular dynamics analysis of protein-lipid interactions.

nature.com

🚨Job Alert🚨 As part of our BBSRC sLoLa award, David Roper, @seamusholden.bsky.social and I have three 5-year PDRA positions available. Each is individually tailored to our groups, but will be part of the larger interdisciplinary team; also including Stephen Cochrane's group at QUB: t.co/alJ0re8BBh