Frontiers | Genomic variant-driven prediction of azole resistance in Aspergillus fumigatus using GWAS and machine learning

Azole resistance in Aspergillus fumigatus, a major cause of invasive aspergillosis, threatens public health. Known drivers include cyp51A/B mutations (e.g., ...

frontiersin.org

Epistasis limits but does not prevent the transfer of mutation-drug resistance mapping across 600 million years of fungal evolution

Whether different pathogens acquire resistance to antimicrobials through the same mutations is a major question in evolution and microbiology. Most antifungal drugs are used to treat infections caused...

biorxiv.org

biorxiv.org

Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load

Understanding the evolutionary mechanisms that maintain sex despite its direct costs is a long-standing challenge. Previous work has shown that sexual recombination can accelerate adaptation, in part ...

science.org

Genome–host association mapping reveals wheat pathogen genes involved in host specialization - Nature Plants

This study introduces genome–host association (GHA), leveraging natural epidemics to map the genetic landscape of host adaptation in the pathogen Zymoseptoria tritici. Applied to 832 wheat fungal stra...

nature.com

Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature - Nature Microbiology

Development of pan-drug resistance and hypervirulence in Rhodosporidiobolus fluvialis are enabled by mutagenesis induced by mammalian body temperature.

nature.com

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution - Nature Ecology & Evolution

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distin...

nature.com

Cross-kingdom RNA interference promotes arbuscular mycorrhiza development - Nature Plants

The authors provide evidence that symbiotic fungi forming widespread arbuscular mycorrhiza symbioses use cross-kingdom RNA interference to silence plant genes and promote their colonization of host ro...

doi.org

The human fungal pathogen Aspergillus fumigatus can produce the highest known number of meiotic crossovers

Aspergillus fumigatus is a saprotrophic fungus that can cause serious life-threatening invasive infections in immunocompromised individuals. By constructing a recombination map, this study shows that ...

journals.plos.org

Transcriptional and metabolic modeling analyses of developing Aspergillus fumigatus biofilms reveal metabolic shifts required for biofilm maturation | mSphere

Aspergillus fumigatus is the most common etiological agent of a collection of diseases termed aspergillosis. Chronic and invasive manifestations of aspergillosis are highlighted by the development of biofilm-like structures on and in tissue. These biofilm structures are resistant to contemporary antifungal drugs, even for strains that are susceptible by standard antimicrobial susceptibility testing methods. Consequently, understanding the mechanisms by which A. fumigatus induces, develops, and maintains biofilms to evade antifungal therapies is expected to illuminate biofilm-specific therapeutic targets. Here, we identify genes involved in fungal fermentation and regulation of transcription as important mediators of A. fumigatus biofilm development.

journals.asm.org

Genomic Insights into Historical Adaptation of Three Key Fungal Plant Pathogens

Abstract. Fungal culture collections hold a wealth of historical isolates that could be used to study fungal evolution over the past decades, an era that c

doi.org

Discovery of globally rare CYP51 mutations associated with azole resistance in Iranian Zymoseptoria tritici isolates - BMC Plant Biology

Background Septoria tritici blotch, caused by Zymoseptoria tritici, is a major wheat disease worldwide. Demethylation inhibitor (DMI) fungicides, which target the sterol 14α-demethylase enzyme encoded...

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Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth

Nature Microbiology - During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of...

rdcu.be

The Macroevolution of Filamentation Morphology Across the Saccharomycotina Yeast Subphylum

Saccharomycotina yeasts are a highly diverse and widely distributed subphylum of ascomycete fungi that exhibit diversity in their asexual growth morphologies; the human commensal yeast Candida albican...

biorxiv.org

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance | The EMBO Journal

imageimageHeterochromatin-island epimutations can provide resistance to caffeine and antifungal drugs in the fission yeast Schizosaccharomyces pombe. This study reveals that some epimutations cause re...

embopress.org

A large European diversity panel reveals complex azole fungicide resistance gains of a major wheat pathogen | mBio

Sustainable food production requires the management of disease agents attacking crops. Application of antifungal compounds is among the key elements of pathogen containment; however, resistance can ri...

journals.asm.org

Three-dimensional genome architecture connects chromatin structure and function in a major wheat pathogen - BMC Biology

Background Genome spatial organization plays a fundamental role in biological function across all domains of life. While the principles of nuclear architecture have been well-characterized in animals ...

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