Guillaume Bossis
@guillaumebo6.bsky.social
Biologist, PI @igmm-montpel.bsky.social @cnrs.bsky.social, Montpellier, France. Acute Myeloid Leukemia and SUMOylation https://www.igmm.cnrs.fr/en/team/sumoaml/
🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.
go.nature.com
🔥 The #EMBOSUMO workshop kicks off TODAY! 🎉 Thanks @embo.org @biologists.bsky.social @proteocure.bsky.social @sebiology.bsky.social @newphyt.bsky.social @umontpellier.bsky.social @occitanie.bsky.social for their support. More info: meetings.embo.org/event/25-sum...
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis. www.cell.com/trends/cance...
Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis
Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...
cell.com
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation www.biorxiv.org/content/10.1... @embl.org
📣 Happy to share our last publication on SUMOylation and Natural Killers in AML. aacrjournals.org/mct/article-...
Targeting SUMOylation triggers interferon-ß-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia
Abstract. Natural Killer (NK) cells can play a significant role in the anti-tumoral immune response. In patients with Acute Myeloid Leukemia (AML), NK cells are however often found in low numbers and ...
aacrjournals.org
📢 The 21st Annual Meeting of Cancéropôle GSO is back! 🗓️ November 26–28, 2025 in Agen Join us around cancer research ! Abstract submissions: Oral: until September 19 Posters: until October 3 👉Registration: until October 31 More info: kgso.fr/events/21st-...
📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
Learn more about SUMOylation at EMBO Workshop "SUMOylation: From discovery to translation" in La Grande Motte, France, 22–25 September 2025 Early Bird Registration/Abstract Submission by 1 May Late Bird Registration by 1 June meetings.embo.org/event/25-sum... #EMBOsumoylation #EMBOevents 🧪
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome. www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
biorxiv.org
Hello Ubiquitin-like fans, check this 👇👇👇 Early Bird Registration Deadline 🗓️ 1 May 2025 Abstract Submission Deadline 🗓️ 1 May 2025 Don't miss the date! @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social #ubiquitin #SUMO #EMBO Workshop meetings.embo.org/event/25-sum...
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
Guillaume Bossis@guillaumebo6.bsky.social · 2y agoReminder: join us for the @embo.org Workshop SUMOylation: from discovery to translation, Sept 22-25 in La Grande Motte. With the support of @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social. Don't wait to register meetings.embo.org/event/25-sum...
🚀 Excited to share our latest article in #singlecell proteomics published in Cell! We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution! www.cell.com/cell/fulltex...
Global analysis of protein turnover dynamics in single cells
The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.
eur02.safelinks.protection.outlook.com
🚨🚨 This is a very clear signal to all us researcher to stay off the US for the next three years: A French academic, who was on assignment from the CNRS, was detained by officers & later deported after landing at George Bush International Airport ahead of conference.🧵 www.lbc.co.uk/world-news/d...
Diplomatic row erupts after French researcher expelled from US for expressing 'a personal opinion' on Trump
A diplomatic row has erupted between France and the US after a French researcher was expelled from the country for expressing "a personal opinion" on Trump.
lbc.co.uk
Reminder: join us for the @embo.org Workshop SUMOylation: from discovery to translation, Sept 22-25 in La Grande Motte. With the support of @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social. Don't wait to register meetings.embo.org/event/25-sum...
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social dlvr.it/TJN3yl @cp-molcell.bsky.social @unibirmingham.bsky.social
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...
dlvr.it
Today, more than 10,000 people across the United States and beyond Stood Up for Science. I feel deeply humbled, inspired, and energized—our work is far from over, but witnessing so many people unite to champion science and the hope it brings is truly incredible.
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
Charlie Hebdo@charliehebdo.fr · 2y agoLe dessin du jour, par Juin
My favorite thing about the @standupforscience.bsky.social map is that the French people obviously maintain their solidarity and know the history of our joint venture in revolution. Those in power in the U.S. would have us forget this, but I ’ll be Santa Fe tomorrow, how’s about you?
Les rassemblements, débats, discussions ouvertes et marches s'organisent vite : - Retrouvez toutes les informations des initiatives existantes - Inscrivez les nouvelles en moins de 2 min standupforscience.fr/tous-les-eve...
Tous les évènements | Stand Up For Science France
standupforscience.fr
"The universities control the knowledge in our society (...) We have to agressivly attack the universities (...). Fundamental lies that feminism is liberating (...) There is wisdom in what Nixon said, the professors are the enemy " bryanalexander.org/politics/the... www.youtube.com/watch?v=0FR6...
J.D. Vance | The Universities are the Enemy | National Conservatism Conference II
YouTube video by National Conservatism
youtube.com
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks. https://go.nature.com/4kd1vIu
Trump 2.0: an assault on science anywhere is an assault on science everywhere
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
go.nature.com
On March 7, let's stand up for science! 🔬✊ In solidarity with Stand Up For Science US (@standupforscience.bsky.social) and in response to threats against scientific institutions, actions will take place in every university city in France. Info & registration 👉 standupforscience.fr
Message to our European colleagues : we can help you create events in your country / cities.
Stand Up For Science France@standupforscifr.bsky.social · 2y agoOn March 7, let's stand up for science! 🔬✊ In solidarity with Stand Up For Science US (@standupforscience.bsky.social) and in response to threats against scientific institutions, actions will take place in every university city in France. Info & registration 👉 standupforscience.fr
