Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...
James Galbraith
@gulbruth.bsky.social
Evolutionary biologist, Luddite, coffee addict. Postdoc at University of Edinburgh researching the evolution of weird chromosomes and sex determination in insects, opinions my own, he/him.
New preprint: 338 coleopteran genomes reveal exceptional rearrangement variation compared to other insect orders. Big congrats to @arf-mln.bsky.social, for getting this giant piece together. Big collaboration of @joanameier.bsky.social's and my groups. 🧵👇 doi.org/10.64898/202...
Here's my story from Pine Gap. "The fight to end the US military occupation of Australia (and the entire world)" It's a photo-essay this time because I took a tonne of pics, the country being this stunning, to help convey the Arrernte's struggle.
The fight to end the US military occupation of Australia (and the entire world) - The Shot
For 64 years – an insignificant speck of time under a sky this large – from a stolen, sacred site...
theshot.net.au
Not saying that game was stolen from Egypt but it is now on display at museum in London.
How good is MiniBWA, the successor to BWA? To test it, I ran MiniBWA on sequencing from 76 different species, comparing mapping speed, rate and accuracy with BWA MEM. In short, it's really good. If you map short reads, it's well worth your time. andrewcarroll.github.io/2026/06/30/t...
The Best of Both Worlds - Assessing MiniBWA
Recently, Heng Li released MiniBWA (GitHub) alongside a paper by Heng Li and Nils Homer describing the method (paper). MiniBWA builds on the approaches in Minimap2 (also by Heng Li), but falls back on...
andrewcarroll.github.io
Presenting my progress working with lichen genomics at #SMBE2026 in the symposium L04 Understanding adaptive evolution through the lens of hologenomics 🙆🏻♀️
Our paper is out! 📣 we find that molecular measures of genetic variation do not predict heritable genetic variation across species - important implications for the application of genomic data for conservation! www.pnas.org/doi/10.1073/...
Nucleotide diversity is a poor predictor of short-term adaptive potential | PNAS
The capacity to adapt is essential for a population to avoid extinction in a changing world and is recognized as a global conservation priority. Ad...
pnas.org
🚀 new bwa-mem3 is out. Why use it? - 🏛️keep using a bwa-mem variant (avoid revalidation/reprocessing) - 🚅 1.7x faster/20% less memory than bwa-mem2 - 🧬native methylation support (asymmetric scoring) - ✅ matches bwa-mem2 output - 👊opt-in knobs to go even 2x faster bwa-mem3.readthedocs.io/en/latest/
Home - bwa-mem3
Accelerated short-read alignment, derived from bwa-mem2
bwa-mem3.readthedocs.io
Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357
Ask how many more shifts they’d let a surgeon work after a week in which they severely harmed 12-15% of their patients
“In a recent study looking at the use of AI in healthcare, researchers from Stanford and Harvard found even top-performing AI models from Anthropic and Google produced 12 to 15 severely harmful errors per 100 cases. The worst-performing models made mistakes in 40 out of 100 cases.”
Major development in the #Transposon world! Repbase is joining the Dfam project and becomes open-access! link.springer.com/article/10.1...
Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA
Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...
link.springer.com
A New Open Foundation for TE Research: GIRI is transitioning the full Repbase collection to an open-access license and joining the Dfam effort to help build a unified open resource for transposable element research. Full announcement: tinyurl.com/48665xss
My main PhD paper is out on bioRxiv! 🎉 The microbiomes of wild animals, besides the gut, remain unexplored. To help remedy this, we used museum-preserved dental calculus to characterise the oral microbiome of 34 diverse mammal species. 💀🦠🦷 Read here: www.biorxiv.org/content/10.6...
Over the moon! It's an incredible honour to be named a Lister Prize fellow. And excited to begin this project! We will be building genetic tools (esp. GAL4/UAS) in #Drosophila testacea, a non-model mushroom-feeding fly with a *natural balancer chromosome* to study immune evolution 🧬🪰🍄 1/2
Our congratulations to 👉️ @chrisgreene.bsky.social at RSCI University of Medicine and Health Sciences 👉️ @hansonmark.bsky.social at @exeter.ac.uk 👉️ @anjalihinch.bsky.social at @dunnschool.bsky.social 👉️ @lautenschlagerlab.bsky.social at @ucl.ac.uk lister-institute.org.uk/news/our-lis...
Biodiversity doesn’t always arise through isolation. Genomic analyses of sailfin silversides from Sulawesi reveal that ancient and recent gene flow fueled their adaptive radiation, contributing to the evolution of unique forms within a single lake system. #LIBresearch © De Keyzer et al., CC BY 1/3
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
nytimes.com
Nature research paper: A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone go.nature.com/4v1yiFk
A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone - Nature
Researchers uncovered an enormous deep-sea accumulation of whale remains in the southeastern Indian Ocean, showing long-term, specialized ecosystems and an extensive fossil record that offers new insight into deep-ocean biodiversity and whale evolutionary history.
go.nature.com
📣🧬 Postdoc Alert🧬📣 We are hiring a 2+ year NERC-funded postdoc at Edinburgh Uni investigating causes and consequences of sex differences in recombination in house sparrows in Norway. Informal enquiries welcome at Susan.Johnston@ed.ac.uk 🙂 Details here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
On the one-year anniversary of EMPIRE OF AI, I am so, so excited to announce The AI Resist List, a new project that documents examples of resistance to the AI empires around the world 😍 airesistlist.org
Host-transposable element coexistence: a matter of resistance, tolerance and trade-off Read this new review by Séverine Chambeyron, Charlotte Grimaud, Mikiko Siomi et al link.springer.com/article/10.1...
“It's making me dumber for sure.”
Software Developers Say AI Is Rotting Their Brains
“It's making me dumber for sure.”
404media.co
Not all political donations are easy to trace. About 1 in 10 of donations to Scots parties come from ‘dark money’ groups that don’t have to reveal where their money comes from
Businessmen and wealthy donors are bankrolling Scottish politics. Who are they?
The Ferret did a deep dive into the Electoral Commission’s donation records to find out who was funding Scotland's political parties.
theferret.scot
Among many other things, generative AI is a labor rights issue. Professors are right to reject it and students are right to join the rebellion.
Cal State struck a deal with OpenAI. Some students and faculty refuse to use it
California State University’s $17 million contract with OpenAI is up for renewal. Some say AI is crucial for the workforce. Others say it’s cheating.
calmatters.org
Last week, a 20 year-old man threw a molotov cocktail at Sam Altman's mansion; two days later, people fired a gun at it. Earlier that week, someone fired gunshots into an city councilman's house who approved a data center. Why the AI backlash has turned violent:
Why the AI backlash has turned violent
And why it's probably only going to get worse from here.
bloodinthemachine.com
🎉 EarlGrey ParTEA v0.1.6 is here! Huge thanks to everyone who's tried the pipeline and shared feedback — your suggestions directly shaped these new features. 🍵 #TEworldwide #transposableelements #bioinformatics #genomics
Question for people who were alive for Bay of Pigs or other tense geopolitical moments like now: How did you focus on things other than the potential destruction of humanity?
Movements to shut down or ban data centers are amassing power and notching victories. Wikipedia has banned AI-generated content in articles. Publishers and entertainment studios are being pushed to reject AI-produced content outright. In other words: It's open season for refusing AI.
It's open season for refusing AI
There's been a wave of successful efforts to ban, reject and shut down AI.
bloodinthemachine.com
In the new TMK, we're joined by @katemac.bsky.social and @70sbachchan.bsky.social from @thepolycrisis.bsky.social to chat about the war in Iran, fossil fuel demand destruction, forced energy transitions, plus much more. www.patreon.com/posts/154551...
451. Do Not Become Addicted to Electrons (ft. Tim Sahay, Kate Mackenzie) | This Machine Kills
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