Hi friends! I am a guest editor for a new collection in BMC Biology called "Pluripotency, differentiation, and reprogramming" and we just opened for submissions. Looking for research articles and reviews, please reach out if you are interested. I'm excited for helping with this collection!

The talented @isa-ozdemir.bsky.social wrote a review of CHD remodelers, discussing all 9 family members and their roles in ES cells and early development. dx.doi.org/10.1002/bies... 1/2

Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity

In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 mete...

dx.doi.org

How has #evolution shaped Transcription Elongation Factors, important for #GeneExpression? This study by Alex Francette, Karen Arndt &co traces ten core factors to the last eukaryotic common ancestor, and shows they display both conserved and lineage-specific domains. 🧪#AcademicSky plos.io/4eaCUTJ

New in #GENETICS from @hainerlab.bsky.social: The nucleosome remodelers esBAF and INO80 selectively influence subcompartment identity and enhancer–promoter communication at key regulatory loci during higher-order chromatin organization in mice. 🔗 buff.ly/0eU5xg0

Great thread from an @nationalacademies.org award winner highlighting the current cowardice and capitulation of NAS, tech industry and the leaders of both to the demands of Trump that are destroying American science 🧪

M.J. Crockett@mjcrockett.bsky.social · 3mo ago

Last weekend I received the Troland Research Award from the @nationalacademies.org. I’m so grateful to the communities who made this work possible. It's strange to receive this award at a time when much of the work being recognized is not eligible for federal funding. My remarks 👇 and a 🧵>>

Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...

Incredibly proud to share our new preprint, lead by the Incomparable Rithika Sankar. Here we temporally dissect the role of FACT in mES cells, finding that FACT loss drives progressive deterioration of chromatin architecture, leading to transcriptional collapse. www.biorxiv.org/content/10.6...

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells. A great colleague, a friend and a lovely person.

Happy Black History Month! I am sharing a permanent and continuously updated list of inspiring Black scientists! Check it out! Huge thank you to the folks who gathered this info. Thank you to @drstarbird.bsky.social and the rest of the Index Committee! www.wiley.com/en-us/resear...

Index of Inspiring Black Scientists | Wiley

The Inspiring Black Scientists Index is a curated database celebrating diverse contributions to science. Join us in promoting education and collaboration.

wiley.com

Proud to be Canadian 🇨🇦 www.cbc.ca/news/politic...

Read Mark Carney's full speech on middle powers navigating a rapidly changing world | CBC News

Read the full text of Prime Minister Mark Carney's speech about a shakeup of the global order and role of middle powers at the World Economic Forum in Davos, Switzerland.

cbc.ca

* vaccines keep kids from dying * guns cause kids to die these are unassailable conclusions based on mountains of evidence it is a crying shame that politicians pretend otherwise, endangering our kids and everyone else’s

Comment period ends on Monday for a proposed rule change that would terminate student visas after 4 years. It also puts limits on exchange visitors and reps of foreign media, and shortens the length of time at the end of the visa from 60 days to 30 days. www.federalregister.gov/documents/20...

Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media

Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...

federalregister.gov

New preprint is up, led by former postdoc Braulio Bonilla. We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C. www.biorxiv.org/content/10.1...

esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions

The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucl...

biorxiv.org

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes

Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

doi.org

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial. rdcu.be/exXBX

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

The successful candidate will oversee the management and direction of the OSU Herbarium and establish an independent research program by conducting original research in an area of plant systematics, ecology, and/or evolution.

Assistant/Associate/Full Professor (Botany & Plant Pathology)

The Department of Botany and Plant Pathology invites applications for a full-time (1.00 FTE), 9-month, tenure-track or tenured Assistant, Associate, or Full Professor position.Any hiring at the rank o...

jobs.oregonstate.edu

We built a team to represent a coalition of unions, non-profits, & local governments in the largest lawsuit challenging Trump’s authority to remake the government without congressional approval. Trump's efforts to dismantle the federal government are unconstitutional and we will see him in court.

Interested in synthetic approaches to both understand and manipulate gene expression? We (the Bintu lab) wrote a review that discusses just that - how modern low- and high-throughput approaches can dissect gene regulation at the DNA, RNA, and protein level. www.annualreviews.org/content/jour...

ATTENTION: NSF GRANT RECIPIENTS We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years. 1/n

a cartoon of a man holding a frying pan and a spoon with red alert written above him

ALT: a cartoon of a man holding a frying pan and a spoon with red alert written above him

media.tenor.com

Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag Nadiya Khyzha ∙ Kami Ahmad∙ Steven Henikoff www.cell.com/molecular-ce...

Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag

Khyzha et al. developed SLAM-RT&Tag, a kinetic labeling strategy for profiling RNA dynamics within nuclear compartments. Applied to Polycomb domains and nuclear speckles, they identified compartment-s...

cell.com

Join us at the 2025 Epigenetics Society International Conference in Chicago! Discover the latest in DNA, RNA, and chromatin epigenetics, steps from Navy Pier & Michigan Ave! www.esconference25.com. #Epigenetics2025 #DNA #RNA #Chromatin #ScientificConference #Chicago

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

forbes.com

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

First @fnucleosome.bsky.social talks of the year coming up on Wednesday! Register to join us And, if you're interested in presenting with us this year, you can fill out this survey: docs.google.com/forms/d/e/1F...

Application to speak in the Fragile Nucleosome series

Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

docs.google.com

FragileNucleosome@fnucleosome.bsky.social · 2y ago

We also have some exciting news and announcements!🥁 #FragileNucleosome is back this Wednesday, January 29th, at 9am PST/5pm GMT! We are excited to kick-off 2025 seminars, hosting Jaime and Melica, two amazing ECR scientists! 🗓️Don't forget to register: us06web.zoom.us/webinar/regi...

In case you missed them, a number of our @fnucleosome.bsky.social talks from 2024 are now up on our youtube channel! Check out the recently uploaded seminars below: Julia Rogers: Notch induces transcription by stimulating release of paused RNA Pol II www.youtube.com/watch?v=GME2...

Julia Rogers

YouTube video by Fragile Nucleosome

youtube.com

PhD studentship! Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon! Honestly, what more could you want? APPLY NOW! Deadline Friday 10 Jan! @lsiexeter.bsky.social

Surfin' NuRD@surfinnurd.bsky.social · 2y ago

Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social "Control of chromatin remodeller activity to direct cell fate decisions" #Chromatin #Transcription #StemCells #StructuralBiology Please re-skeet! www.exeter.ac.uk/research/ins...