Thrilled to share our latest work highlighting Bergmann glial development in the human cerebellum. @neurodevkathy.bsky.social @pnas.org www.pnas.org/doi/10.1073/...

Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia | PNAS

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity...

pnas.org

Happy Thanksgiving! To cap off 2025, we are pleased to share our Perspective piece in @cp-devcell.bsky.social on medulloblastoma stem cell programs. www.cell.com/developmenta...

Medulloblastoma stem cell programs: Molecular roadmaps of disease progression

In this perspective, Zagozewski et al. summarize current knowledge about the primitive neurodevelopmental programs that drive medulloblastoma progression. The authors also highlight the unmet needs in...

cell.com

Fascinating new paper demonstrating that broad cerebellar output scaffolds emerge at strikingly early embryonic stages.

Meike van der Heijden@meikeesther.bsky.social · 11mo ago

Nice cerebellum development paper 👀 www.pnas.org/doi/10.1073/...

Beautiful work from James Li’s lab, out in @natneuro.nature.com, dissecting the role of FOXP genes [mostly, FOXP1 and FOXP2] in regulating Purkinje cell diversity and cerebellar hemisphere developnent 🧪🧠🧬 www.nature.com/articles/s41...

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis - Nature Neuroscience

The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity and that Foxp1+ PC...

nature.com

Sarah characteristically turning a bonkers story into a fascinating one.

Sarah Churchwell@sarahchurchwell.bsky.social · last yr.

Americans put sugar in all kinds of dishes that don’t require it. And one of the main reasons for this national aberration is … Prohibition. 🧵

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...

biorxiv.org

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

nature.com

Happy 99th birthday to the man who gave voice to the wild. 🎉 Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace. You've inspired generations to fall in love with nature.

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

science.org

Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development @cp-cell.bsky.social www.cell.com/cell/abstrac...

Regional differences in progenitor metabolism shape brain growth during development

Brain-wide birthdate mapping reveals that while hindbrain neurogenesis is transient, forebrain neurogenesis is temporally sustained through spatiotemporal regulation of progenitor mitochondrial functi...

cell.com

🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...

It’s been a hectic few days, here’s a quick thread on our latest endeavour exploring GABAergic neurogenesis in the human cerebellum published in @pnas.org. Key takeaways: Purkinje cells are born very early in human development — much earlier than previously appreciated. www.pnas.org/doi/10.1073/...

Mapping the developmental profile of ventricular zone–derived neurons in the human cerebellum | PNAS

The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs...

pnas.org

Inspired by Cajal, the Hansel lab’s new work in @eLife provides a comparative histological analysis of human and mouse Purkinje cell morphology. Following our 2023 study, we detail differences of scale and kind between the neurons of the two species 🧵⬇️ elifesciences.org/articles/105...

Non-allometric expansion and enhanced compartmentalization of Purkinje cell dendrites in the human cerebellum

A comparative study of Purkinje dendrite morphology, input arrangement, and regional subtype distribution shows human cells evade constraint by cortical thickness to be both quantitatively and qualita...

elifesciences.org

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

Please be a kind and considerate reviewer, even if you have criticism (think of the first author who poured their heart and soul into the work). Also, read the paper or revisions and make sure you don't suggest experiments that are already in the manuscript... 😂

Mackenzie Weygandt Mathis@trackingactions.bsky.social · 2y ago

What is with journal paper reviewers these days? As another reviewer doing cross discussions (cough, Science), I’m seeing a lot of hostile, aggressive comments. You know, you can package things kindly if you think you found a mistake? Literally I’m having to flag inappropriate comments to editor 🙃🤯

Great paper by @noonanlab.bsky.social, now out in Cell, on the role of “human accelerated regions” in human brain evolution; showing they altered the expression of ancestral gene targets shared between human and chimpanzee rather than by gained new targets in human 🧪🧠🧬 www.cell.com/cell/abstrac...

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment

Human accelerated regions (HARs) have been implicated in human brain evolution with limited understanding of the biological processes they alter. This study reports that HARs influenced brain evolutio...

cell.com

Someone in 1st Century India got human embryonic limb development perfectly right. The progressive emergence of parts, even the timing, exactly right. Today, I'll start a new thing about the ancient origins developmental biology, the science of embryos. 🧵1/15 #TheLongBibliography #DevBiol #SciHist

It's becoming increasingly apparent that people with knowledge need to respond quickly and forcefully in the face of false rumors. (Recent "drone" hysteria in New Jersey is just one example.) Here, Nicole Rust on the necessity of scientific outreach in 2025: www.thetransmitter.org/craft-and-ca...

In your New Year’s resolutions for 2025, consider public outreach

If every person in the neuroscience community committed to doing one thing, imagine the cumulative difference it would make.

thetransmitter.org

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip www.nature.com/articles/s41...

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip - Nature Genetics

Analysis of medulloblastomas in humans and mice shows that the functional consequences of ZIC1 mutations are exquisitely dependent on the cells of origin that give rise to different subgroups of medul...

nature.com

Excited to announce the publication of our team's work suggesting a new framework for understanding hashtag#synapse hashtag#development and diversity in the mammalian hashtag#brain in Nature Neuroscience rdcu.be/d2100 🧵

Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells

Nature Neuroscience - Brain function requires the formation of diverse and specific synapses. The authors show that the molecular code specifying excitatory connectivity on Purkinje cells evolves...

rdcu.be

We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social

Generation and long-term culture of human cerebellar organoids from pluripotent stem cells

Nature Protocols - Generation and long-term culture of a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicates the cellular diversity of the fetal...

rdcu.be

Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social

Annual morbidity in the 20th century, before and after vaccines: Measles: Before: 530,000, After: 47 Mumps: Before: 160,000, After: 429 Rubella: Before: 50,000, After: 3 Diphtheria: Before: 20,000, After: 2 Smallpox: Before: 30,000, After: 0 Polio: Before: 16,000, After: 0

I'm thrilled to announce that the review I wrote with @brainevodevo.bsky.social is now online @Nature Review Neuroscience: www.nature.com/articles/s41... We cover mechanisms of prolonged human neuronal maturation, integrating lessons from model organisms with studies on species differences.

Human neuronal maturation comes of age: cellular mechanisms and species differences - Nature Reviews...

Human cortical neurons undergo a protracted period of postmitotic maturation compared with those of other species. Wallace and Pollen review the cell-intrinsic and cell-extrinsic mechanisms that gover...

nature.com

Nice new #brainorganoid preprint from @knoblich-lab.bsky.social, providing evidence for generation of large portionsof fetal brain cells across several pluripotent stem cell lines, across 4 protocols. Very valuable resource for the field:

@knoblich-lab.bsky.social · 2y ago

Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher-esk.bsky.social) and colleagues across Vienna. @maxperutzlabs.bsky.social, @IMBA_Vienna, @CeMM_News.

Hi Bluesky 🧪🧠, Let me introduce my second postdoctoral piece published a couple of weeks ago, under the direction of @vanderhaeghenp2.bsky.social, with @franckp.bsky.social and Cécile Charrier, in #Neuron @cellpress.bsky.social 🧵: doi.org/10.1016/j.ne... #neuron #neoteny #human #SYNGAP1

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Libé-Philippot et al. investigate the mechanisms underlying the prolonged synaptic development characteristic of human cortical neurons. They demonstrate that the human-specific genes SRGAP2B/C are re...

cell.com