Nothing in neural activity makes sense except in the light of dynamics and cybernetics. #CCN2026 GAC position. sites.google.com/ccneuro.org/...

GACs - 2026-3

Representations or Transformations: What Should Models of Neural Population Activity Explain? Julian Kędys, Poznan Supercomputing and Networking Center Cezary Mazurek, Poznan Supercomputing and Netwo...

sites.google.com

www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

Multiple contact sites between cells and the vitelline envelope coordinate tissue flows in Drosophila gastrulation

Gastrulation is thought to be driven primarily by forces generated within individual cells. These cell-intrinsic forces collectively induce tissue-scale flows and transform the monolayered embryo into...

biorxiv.org

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

Not the moon.

It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...

Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)

Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...

forum.image.sc

Important for parents of (pre)-teens to keep in mind. Surveillance brings anxiety, trust begets trust

Dan Rosen@danrosen.xyz · 3w ago

I think people understandably but magically believe that surveilling your loved ones will protect them from harm because it promises knowledge and control. But when you get more knowledge but little actual control, your anxiety goes through the roof

Story time friends... Ring attractor networks rely on fine-tuned symmetric connectivity. The fly head direction network has ring attractor dynamics but heterogeneous connectivity. How is this possible? 1/🧵 Link: www.biorxiv.org/content/10.6...

With a motivating push from @christlet.bsky.social I made a new Fiji plugin, CurveMorph. The idea was to create a tool for kymograph generation along the dynamic (bending/shaking) filament shapes (microtubules, cilia, neurites, etc). The logo was made using the plugin. github.com/UU-cellbiolo...

Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior, & building AI-in-the-Loop Discovery — a new way of doing biology. Tiny transparent fish + one of neuroscience’s biggest questions? Let's go: hhmi.news/2BigBets

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

Nice piece in @theharvardcrimson.bsky.social about our @kempnerinstitute.bsky.social! I say a few things in it.

Harvard's Kempner Institute Bet Big on AI. Now It Has to Prove Itself. | News | The Harvard Crimson

Harvard’s Kempner Institute made an early bet on owning its own AI computing cluster — a gamble that has quickly made it a rare academic hub for artificial intelligence research, even as private indus...

thecrimson.com

1/ 🚨🚨Preprint alert! "Perfect" isn't always smart 🧠. Anyone can tell apart two stimuli (including our mice). But how do we extract rules that apply to new stimuli? 🧵 biorxiv.org/content/10.6... @marius10p.bsky.social @computingnature.bsky.social #neuroAI #neuroscience #AI

New release of #BigVolumeBrowser (0.1.1) adds support for (multiscale) OME-Zarr (thanks to libraries from @bogovicj.bsky.social, Stefan Hahmann, Vladimir Ulman). And midi gizmo navigation (from @herrsaalfeld.bsky.social ), shown below.

New preprint with @lingqiz.bsky.social: Neurodata Without Boredom: Benchmarking Agentic AI for Data Reuse arxiv.org/abs/2605.12808 1/10

Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options

Neuron@cp-neuron.bsky.social · 3mo ago

1/7 New paper accepted as ICML spotlight arxiv.org/abs/2605.03517! We unify self-supervised learning (SSL) algorithms (e.g., contrastive, VICReg, stopgrad) via latent distribution matching (LDM), which matches an induced latent distribution to an explicit latent model.

New paper out! Left-handed DNA cannot bind to natural, right-handed DNA. This leads to lower background if it is used as a probe in DNA-PAINT. Using Fluorigenic DNA-PAINT with left-handed DNA allows for low background, fast 3D DNA-PAINT! Congrats, Bas! skeetorial: 1/x pubs.acs.org/doi/full/10....

Accelerated Left-Handed DNA-PAINT Using Fluorogenic Probes

Single-molecule localization microscopy (SMLM) techniques offer nanometer-scale resolution by stochastically localizing individual fluorescent molecules. Among these, DNA-mediated point accumulation f...

pubs.acs.org

After 9 years, I am finally finishing the story about normalized cross-correlation (and reviving my blog). The new blog post about deep technical details on the most used image registration technique. I know y'all have been waiting. katpyxa.info/feedbacks/?p...

"Warm models showed substantially higher error rates (+10 to +30 percentage points) than their original counterparts, promoting conspiracy theories, providing inaccurate factual information and offering incorrect medical advice. " rdcu.be/fgea6

Training language models to be warm can reduce accuracy and increase sycophancy

Nature - Experiments on five different language models show that training language models to produce warmer responses can undermine the accuracy of their output, especially when users express...

rdcu.be

Can generative AI accelerate neuroscience? Excited to share MoGen at ICLR 2026!🧠 We use point cloud flow matching to generate high-fidelity 3D neuron fragments, capturing intricate details like dendritic spines.

Eating its own tail, the central dogma of molecular biology has come full circle! 🧬

Pujuan Poppy Deng@poppy-pujuan-deng.bsky.social · 4mo ago

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

New @currentbiology.bsky.social paper from Dr. Leila Elabbady on neural circuits that transform a touch stimulus into spatially targeted grooming. Leila discovered a leg somatotopic map and used it to infer tactile receptive fields in the fly VNC connectome. authors.elsevier.com/a/1mvu83QW8S...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods

A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

nature.com

Check out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1

Last call!

Janelia Conferences@janeliaconf.bsky.social · 4mo ago

🚨 Deadline approaching (Apr 16)! Don’t miss your chance to join our student-led #TheoreticalBiophysics workshop. Meals, accommodation + reasonable travel covered for accepted participants. Apply ➡️ janelia.news/THB26 @allysonsgro.bsky.social @zamakany.bsky.social

Big opportunities for researchers 🌍 We are investing nearly €400 million to help researchers share their work and collaborate with the best scientific teams across the EU. The 2026 Marie Skłodowska-Curie Actions Postdoctoral Fellowships are now open. More: link.europa.eu/PNxpxw

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

🚨 Deadline approaching (Apr 16)! Don’t miss your chance to join our student-led #TheoreticalBiophysics workshop. Meals, accommodation + reasonable travel covered for accepted participants. Apply ➡️ janelia.news/THB26 @allysonsgro.bsky.social @zamakany.bsky.social

Janelia Conferences@janeliaconf.bsky.social · 7mo ago

Students & postdocs 👉 Apply by April 16 for our hands-on #TheoreticalBiophysics workshop featuring participant talks, tutorials & lively discussions. ✅ No registration fee 🍽️ Meals & hotel covered ✈️ Travel support available Apply ➡️ janelia.news/THB26 @allysonsgro.bsky.social @zamakany.bsky.social

Applications are open for the Junior Theoretical Neuroscientists Workshop which will take place July 21-24, 2026 at the Center for Computational Neuroscience, @flatironinstitute.org Travel, lodging, and meals will be covered for accepted participants. Application deadline: April 15, 2026