***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social

Generative replay across hippocampal-neocortical circuits

To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...

biorxiv.org

Hi all, we're on the look out for a postdoctoral researcher with links to Denmark who would interested in applying for a Novo Nordisk Fellowship to join a collaborative endeavour between Oxford and Copenhagen (novonordiskfonden.dk/en/grant/pos...).

Postdoctoral Fellowships at University of Oxford - 2026 - Novo Nordisk Fonden

novonordiskfonden.dk

Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...

Excited to highlight a new paper from my graduate student Sergio Bernal Garcia who, together withLuke Hammond, developed RESPAN, a new deep-learning pipeline automating the segmentation of neuronal morphology and dendritic spines from fluorescent microscopy images: www.cell.com/cell-reports...

A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines

Garcia et al. present RESPAN, a pipeline that enables automated dendritic spine analysis through seamless integration of deep learning image restoration and segmentation capabilities with comprehensiv...

cell.com

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex

Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

sciencedirect.com

Two faculty positions in my department this year. Please spread the word! And don't hesitate to reach out if you want to learn more.

Psychology at the University of Iowa@psychiowa.bsky.social · last yr.

Heads up! We are doing two searches this year—for an assistant prof in Clinical Science, and an associate/full prof in any domain of psychology. Want to learn more? Contact the dept chair, Mark Blumberg, at mark-blumberg@uiowa.edu. Ads will be posted soon on our homepage: psychology.uiowa.edu

Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms. We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.

Save the date! We're organising a workshop on Data Sharing on the 10th of February at Guy's Campus (KCL)! All you need to know to make your datasets open to the public + engaging in open science practices. More details to come soon — stay tuned!

Congratulations to Gabriel! @interneuron.bsky.social

Well done Ivan! @interneuron.bsky.social

This sounds interesting... definitely one to check out.

John Lukens@lukensjohnr.bsky.social · 2y ago

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus www.nature.com/articles/s41...

Fast-spike interneurons in visual cortical layer 5: Heterogeneous response properties are related to thalamocortical connectivity Some L5 INT with strong input from LGN and visual responses more similar to L4 INT than those receiving little direct LGN input. www.jneurosci.org/content/earl...

Fast-spike interneurons in visual cortical layer 5: Heterogeneous response properties are related to thalamocortical connectivity

Layer 4 of rabbit V1 contains fast-spiking GABAergic interneurons (suspected inhibitory interneurons, SINs) that receive potent synaptic input from the LGN and generate fast, local feed-forward inhibi...

jneurosci.org

We did this. Beautiful work from the 🦋less Gabriel Ocana-Santero & team. More to follow soon but state-dependent neuromodulation is coming to developmental neuroscience in a big way 🧠🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding https://www.biorxiv.org/content/10.1101/2024.12.13.628340v1

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵

Neuroscience methods - YouTube

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

youtube.com

A toolbox for ablating excitatory and inhibitory synapses elifesciences.org/reviewed-pre...

Our 2nd new Doctor in as many days! Many congratulations to Gabi on the successful defence of his thesis (in vivo 5-HT in neurodevelopment; preprint out soon!). Huge thanks to the 🦋less, elite examining team of Oscar Marin & Colin Akerman, also co-PI Trevor Sharp and Serotonin & Beyond @ec.europa.eu

NEW DOCTOR from the lab, Antara Majumdar🥳 🍾 thanks to @kerrywalker.bsky.social @jpassecker.bsky.social for examination & 2nd supervisor @interneuron.bsky.social. Here is Antara's preprint, came out right around the US election and X being deserted: www.biorxiv.org/content/10.1...

Looking for an escape over the holiday? @meikeesther.bsky.social and I published a ViewPoint looking at the intersection of Developmental and Systems Neuroscience titled “More Than a Small Brain: The Importance of Studying Neural Function during Development” www.jneurosci.org/content/44/4...

More Than a Small Brain: The Importance of Studying Neural Function during Development

The nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of “developmental systems neuroscience” combines the molecu...

jneurosci.org

A huge pleasure to repost this announcement - over 40 students have graduated from our fantastic @sussexneuro.bsky.social PhD programme, and each year brings new perspectives and opportunities for both the new joiners and ourselves as their hosts. Do consider applying!

Sussex Neuroscience@sussexneuro.bsky.social · 2y ago

Our Sussex Neuroscience 4-year PhD Programme is open for applications! Deadline Jan 13th, for Sept 2025 entry. Brilliant community of students and supervisors, and a choice of >60 labs for rotations- come and join us by the sea! www.sussex.ac.uk/research/cen...

We are recruiting a PhD student at the Brain, Body, and Self Lab, Department of Neuroscience, Karolinska Institutet. Learn more and apply here: kidoktorand.varbi.com/en/what:job/...

Doctoral (PhD) student position in Cognitive Neuroscience

Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individu

kidoktorand.varbi.com

Neuroscientists! A key message from the ALBA Network Please help us spread the word and share this with your network!!! Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience! 🔎http://loom.ly/_EvQvm4 🗓️20 January 2025

go.bsky.app/43wgshX

Dive into our latest findings on this powerful structure here: “The claustrum is critical for maintaining working memory” biorxiv.org/cgi/content/...

The claustrum is critical for maintaining working memory information

Working memory (WM) enables the mammalian brain to temporarily store and manipulate information, supporting cognitive tasks and communication processes. Rather than depending on a single specialized a...

biorxiv.org

**We are recruiting** Seeking a postdoc to work on a Wellcome-funded cohort study focusing on social-cognitive processing in typically developing children and adolescents (aged 8-18 years) and children and adolescents with 22q11.1 deletion syndrome. www.jobs.cam.ac.uk/job/49291/

Fantastic work by @peruhlen.bsky.social and @kanashigeaki.bsky.social, with a beautiful cover in Science that tells it all! www.science.org/doi/10.1126/...

This made for an interesting read over breakfast: science publishing and behaviour all crammed into 1 article. ‘Mad egghead’ who built a mouse utopia www.theguardian.com/science/2024...

The ‘mad egghead’ who built a mouse utopia

The long read: John Calhoun designed an apartment complex for mice, to examine the effects of overcrowding. It was hailed as a groundbreaking study of social breakdown, but is largely forgotten. So wh...

theguardian.com

@tonyzador.bsky.social on development: "it turns out to be pretty interesting!" shout out to Tony for highlighting what i believe will be an important partnership towards mutual progress developmental neuro 🤝 NeuroAI the future is NeuroDev 🔥 open.spotify.com/episode/3rZ5...

BI 198 Tony Zador: Neuroscience Principles to Improve AI

Brain Inspired · Episode

open.spotify.com

ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...

science.org

Deadline Monday…

Tim Behrens@behrenstimb.bsky.social · 2y ago

2 associate prof neuroscience jobs being advertised in Oxford. Very fun place to do neuroscience:) my.corehr.com/pls/uoxrecru...