Timothy Hla
@hlatim.bsky.social
Scientist, biochemist / molecular biologist, works on lipid mediators, sphingolipids, S1P, prostanoids, vascular biology, endothelial cells, Professor at Harvard Medical School, Boston https://research.childrenshospital.org/hlalab
Latest paper from the Hla lab- @elife.bsky.social: Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions doi.org/10.7554/eLif...
Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions
doi.org
@jasonrkelly.bsky.social interesting post in @bostonglobe.com but I wonder how you are squaring up promoting biotech jobs in Boston with your push for automated labs and AI, which IMHO will reduce the employment footprint. The hand-wavy argument that automation will increase employment wont cut it
Massachusetts built biotech; China is catching up - The Boston Globe
The state can’t afford to lose the state’s signature industry.
bostonglobe.com
An unapologetically angry post about what’s being done to US science:
The Current Crisis: What's Happening to Science in America
science.org
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature: Cell www.cell.com/cell/fulltex...
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...
cell.com
This Is Where Elite Schools Went Wrong www.nytimes.com/2026/05/20/o...
Opinion | A Cattle Ranch Is Doing What the Ivy League Can’t
nytimes.com
AOC on possibly running for the Senate or President: They assume my ambition is a title or a seat. My ambition is way bigger than that. My ambition is to change this country. Presidents come and go, elected officials come and go, single payer healthcare is forever.
Pace of N.I.H. Funding Slows Further in Trump’s Second Year www.nytimes.com/2026/04/22/s...
Pace of N.I.H. Funding Slows Further in Trump’s Second Year
nytimes.com
For those interested in endothelial junctions: our latest paper is out in iScience, and it includes a mass spectrometry based VE-cadherin interactome! Turns out that there are many more molecular intractions going on than just with the catenins… See: www.sciencedirect.com/science/arti...
Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...
I’m a Nobel Prize-winning immigrant. I can no longer recognize this country.
Attacks on science and immigrants are destroying America.
newsletter.ofthebrave.org
Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p
What Happened in Chicago When Science Became the Enemy www.nytimes.com/2026/02/23/o...
Opinion | What Happened in Chicago When Science Became the Enemy
nytimes.com
Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...
Scientists discover why high altitude protects against diabetes | ScienceDaily - goo.gl/alerts/bjpE31 #GoogleAlerts
Scientists discover why high altitude protects against diabetes
Living at high altitude appears to protect against diabetes, and scientists have finally discovered the reason. When oxygen levels drop, red blood cells switch into a new metabolic mode and absorb lar...
goo.gl
In the shadow of ongoing conflict in Myanmar, physician May T. N. Noe forged a path to achieve her academic goals go.nature.com/4tBFSWO
‘I was nearly arrested’: escaping Myanmar’s military leadership for a PhD abroad
In the shadow of ongoing conflict, physician May T. N. Noe forged a path to achieve her academic goals.
go.nature.com
Newly released files from the investigation of convicted sex offender Jeffrey Epstein reveal that his ties to the scientific community were deeper than previously known go.nature.com/46zpg8k
Epstein files reveal deeper ties to scientists than previously known
Nature - Latest batch of documents show researchers consulting the financier and sex offender on publications, visas and more.
go.nature.com
Latest preprint from the lab - what does S1P do to neutrophils ? Click the link to find out… www.biorxiv.org/content/10.6...
biorxiv.org
@raflynn5.bsky.social it’s a pleasure to work with your lab in this exciting discovery- congrats all around!
Ryan Flynn@raflynn5.bsky.social · 7mo agoLike much of our work, this was a very collaborative project with key contributions from @rituraman.bsky.social @hlatim.bsky.social Jeff Esko, Eliezer Calo, Kostas Tzelepis, and many others in the Flynn lab
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...
Dr E Camerer and colleagues @PARCC uncover an essential role for circulating S1P in maintaining blood pressure and left ventricular systolic function. They also highlight distinct functions for the pools of S1P bound to HDL or to albumin. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Latest collaborative paper with Eric Camerer’s lab out now in @pnas.org - comprehensive analysis of S1PRs and chaperones in the cardiovascular system - www.ncbi.nlm.nih.gov/pubmed/41512...
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice - PubMed
Sphingosine 1-phosphate (S1P) is a bioactive lipid that circulates in plasma bound to high-density lipoproteins (HDL) and albumin. Circulating S1P levels correlate positively with systolic blood pressure (BP) in hypertension and negatively with severity in septic shock and with left ventricular func …
ncbi.nlm.nih.gov
How to build a normal multilayered arterial wall?😎 Activated Sphingosine kinase 1 mediates elastin deficiency-induced arterial hypermuscularization🐭 Both Smooth muscle cell & Endothelial cell contribute @junichisaito.bsky.social @greiflab.bsky.social #NatCVR 2026 www.nature.com/articles/s44...
🇨🇦🇨🇦 Just announced: a massive new program from the Canadian govt, separate from the well-known CRCs and CERCs, to recruit foreign scientific talent Canada was already a destination for scientists but whoa. Real impressive for a new govt to back political talking points with serious investment
$1.7 billion to attract international researchers to Canada
Details of the major federal initiative to draw new talent to the country's universities were announced today at UdeM.
nouvelles.umontreal.ca
