New paper from former @holmeslab-bhi.bsky.social post-doc @sidchop.bsky.social. In first-episode psychosis, antipsychotic-naive patients on placebo showed widespread cortical thinning over 12mo. However, patients on antipsychotics did not. Thinning appears to be illness- not drug-driven.

Sidhant Chopra@sidchop.bsky.social · 2w ago

thanks to a large team across Orygen, Monash, Melbourne, Yale and Rutgers Uni. @stephenwood8.bsky.social @avramholmes.bsky.social @dralexholmes.bsky.social @ashleasegal.bsky.social

Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...

Loïc Labache@loiclabache.cpesr.fr · last yr.

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

So excited to share that our study is out now in @natcomms.nature.com! 🧠🚨 www.nature.com/articles/s41... Big shout out to coauthors @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social Rowena Chin Kaley Joss & @avramholmes.bsky.social

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease - Nature Communications

Cocuzza et al. show that brain network dynamics are less flexible in psychiatric illness, and these patterns predict individual symptom profiles better than diagnoses, highlighting brain dynamics as a...

nature.com

⚠️ Preprint alert ⚠️ How does the brain's fixed anatomy support flexible function? We explore this using recurrent neural networks with increasing levels of brain-like constraints, comparing them to empirical fMRI activity. (1/8) www.biorxiv.org/content/10.6...

Geometric constraints and cognitive inputs jointly shape emergent brain dynamics and topology

How the brain's physical geometry gives rise to its flexible functional repertoire remains a central question in neuroscience. Here, we trained three classes of recurrent neural networks (RNNs) on a w...

biorxiv.org

Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social

The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu

Holmes Lab + Parkes Lab had a great fall social a few weeks back!! Pottery painting (including an awesome brain-art mug by @ambrains.bsky.social 🧠). Thank you to our awesome mentors @avramholmes.bsky.social and @lindenmp.bsky.social for encouraging these great lab events! 💫

The @cahbir.bsky.social and @rutgersbhi.bsky.social are hiring! Multiple open area and open rank faculty jobs, wonderful colleagues, amazing resources, and one of the largest communities of brain science research groups on the planet. Please apply and share widely. jobs.rutgers.edu/postings/209...

Latest @holmeslab-bhi.bsky.social preprint. Here, integrating genetic, post-mortem, and diffusion MRI data, Rowena Chin examines the heritability and cellular associates of late-life decline in white matter integrity. @cahbir.bsky.social @rutgersbhi.bsky.social www.biorxiv.org/content/10.1...

The cellular associates of late life changes in white matter microstructure

The microstructural architecture of white matter supporting information flow across local circuits and large-scale networks changes throughout the lifespan. However, the genetic and cellular factors u...

biorxiv.org

Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group! With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social

The Transmitter @thetransmitter.bsky.social · last yr.

When powering fMRI studies, sample size is king, but scan duration can also be a powerful tool, improving phenotypic prediction and cost-efficiency, a new analysis shows By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/fmri/longer-...

🚨Thrilled to share our latest work just published in @nature.com where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS) 🧠⏱️! Full thread below👇:

Thomas Yeo@bttyeo.bsky.social · last yr.

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

This new Yeo Lab tool should immediately and permanently replace sample-size-only power calculations for functional MRI. www.nature.com/articles/s41...

Longer scans boost prediction and cut costs in brain-wide association studies - Nature

Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effect...

nature.com

Thomas Yeo@bttyeo.bsky.social · last yr.

8/ In contrast to standard power calculations, our results suggest that jointly optimizing sample size and scan time can boost prediction accuracy while cutting costs. For more complex study design, you can check out our calculator: thomasyeolab.github.io/OptimalScanT...

Everyone should try out the Trandiagnostic Connectome Project (TCP) dataset! Openly available on @openneuro.bsky.social

Sidhant Chopra@sidchop.bsky.social · last yr.

V useful paper by @bttyeo.bsky.social @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social in @nature.com. Scan longer if you want to predict behav using fMRI and save $. Great use of the TCP data: (pmc.ncbi.nlm.nih.gov/articles/PMC...).

Nature research paper: Longer scans boost prediction and cut costs in brain-wide association studies go.nature.com/3IME4aA

Longer scans boost prediction and cut costs in brain-wide association studies - Nature

Although the number of participants is important for phenotypic prediction accuracy in brain-wide association studies using functional MRI, scanning for at least 30 min offers the greatest cost effectiveness.

go.nature.com

Holmes Lab is representing at #OHBM2025! 🧵 Loic @loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠

Check out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾

Carrisa V. Cocuzza, PhD (she/her)@carrisacocuzza.bsky.social · last yr.

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇

Very cool preprint examining how brain networks and cognition co-evolve during development By @bttyeo.bsky.social @lucinauddin.bsky.social @avramholmes.bsky.social @elvisha.bsky.social & colleagues 🧪🧠 www.biorxiv.org/content/10.1...

Convergent and divergent brain-cognition relationships during development revealed by cross-sectional and longitudinal analyses in the ABCD Study

How brain networks and cognition co-evolve during development remains poorly understood. Using longitudinal data collected at baseline and Year 2 from 2,949 individuals (ages 8.9-13.5) in the Adolesce...

biorxiv.org

Check out my newest preprint to see the TCP dataset in action! 🤘🧠 Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease: www.biorxiv.org/content/10.1...

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease

The network organization of the human brain dynamically reconfigures in response to changing environmental demands, an adaptive process that may be disrupted in a symptom-relevant manner across psychi...

biorxiv.org

Carrisa V. Cocuzza, PhD (she/her)@carrisacocuzza.bsky.social · last yr.

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇

If you missed it, our open source 240-person transdiagnostic dataset is now published. Read the data release 👇👇 + find it on: OpenNeuro: openneuro.org/datasets/ds0... NDA: nda.nih.gov/study.html?i...

Sidhant Chopra@sidchop.bsky.social · last yr.

Check out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇

The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data

Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry

nature.com

Our latest @holmeslab-bhi.bsky.social data release is now "live!" Available on NDA and @openneuro.bsky.social and spearheaded by @carrisacocuzza.bsky.social, @sidchop.bsky.social, and Connor Lawhead.

Carrisa V. Cocuzza, PhD (she/her)@carrisacocuzza.bsky.social · last yr.

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease https://www.biorxiv.org/content/10.1101/2025.05.23.655864v1

New @holmeslab-bhi.bsky.social paper led by @carrisacocuzza.bsky.social. Brain dynamics across task and rest can be used to predict the presence of psychiatric illness (case/control status), diagnostic labels, and multi-dimensional symptom fingerprints. @rutgersbhi.bsky.social @rutgersu.bsky.social

Carrisa V. Cocuzza, PhD (she/her)@carrisacocuzza.bsky.social · last yr.

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

Check out Carrisa's new paper! An amazing investigation into brain network dynamics across psychiatric symptoms🔥🔥 + using our new open dataset the Transdiagnostic Connectome Project (TCP) 🔛 openneuro.org/datasets/ds0...

Carrisa V. Cocuzza, PhD (she/her)@carrisacocuzza.bsky.social · last yr.

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

Great lab outing to Duke Farms yesterday! Happy spring from the Holmes + Parkes labs 😄 🌸 With @lindenmp.bsky.social @avramholmes.bsky.social @carrisacocuzza.bsky.social @ahmadbeyh.bsky.social @loiclabache.bsky.social (+ Amber Howell & Rachel Cooper)

We're searching for a lead Research MRI technologists at @cahbir.bsky.social! Please share and pass along to any/all interested folks.

Center for Advanced Human Brain Imaging Research@cahbir.bsky.social · last yr.

CAHBIR at Rutgers University is looking for a Lead Research MRI Technologist. CAHBIR is a research-only facility that focuses on neuroimaging, and other MR imaging projects. If you are interested, see the information flier linked, and apply online! go.rutgers.edu/mri-tech

Last month Linden Parkes and his team put out an amazing new work! They build on their network control theory model & improved whole-brain structure-function coupling Check this 🧵 for a summary 🔥 www.biorxiv.org/content/10.1...

Inferring macroscopic intrinsic neural timescales using optimal control theory

The temporal evolution of brain activity relies on complex interactions within and between brain regions that are mediated by neurobiology and connectivity. To understand these interactions, many larg...

biorxiv.org

Linden Parkes@lindenmp.bsky.social · last yr.

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘 www.biorxiv.org/content/10.1...

While the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N

Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥

Loïc Labache@loiclabache.cpesr.fr · last yr.

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social

Loïc Labache@loiclabache.cpesr.fr · last yr.

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence