Our latest out now in @natneuro.nature.com led by @trangcao.bsky.social looking at the reproducibility of MRI morphometry phenotypes in psychiatric disorders. Paper: www.nature.com/articles/s41... Thread: x.com/TrangCao2016...

The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders - Nature Neuroscience

A large analysis of MRI studies in five psychiatric disorders reveals that maps of brain volume differences in psychiatric illness are rarely reproducible, highlighting the need for alternative approa...

nature.com

So excited to share that our study is out now in @natcomms.nature.com! 🧠🚨 www.nature.com/articles/s41... Big shout out to coauthors @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social Rowena Chin Kaley Joss & @avramholmes.bsky.social

Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease - Nature Communications

Cocuzza et al. show that brain network dynamics are less flexible in psychiatric illness, and these patterns predict individual symptom profiles better than diagnoses, highlighting brain dynamics as a...

nature.com

Rutgers Health article on @sidchop.bsky.social and @holmeslab-bhi.bsky.social's latest work.

Rutgers Brain Health Institute@rutgersbhi.bsky.social · 3w ago

The study, published in Molecular Psychiatry, was led by senior authors Dr. Avram Holmes @avramholmes.bsky.social and Dr. Rajiv Radhakrishnan at Yale University, and first author former Holmes Lab postdoc, Dr. Sidhant Chopra at Orygen & University of Melbourne. www.nature.com/articles/s41...

The study, published in Molecular Psychiatry, was led by senior authors Dr. Avram Holmes @avramholmes.bsky.social and Dr. Rajiv Radhakrishnan at Yale University, and first author former Holmes Lab postdoc, Dr. Sidhant Chopra at Orygen & University of Melbourne. www.nature.com/articles/s41...

Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...

Loïc Labache@loiclabache.bsky.social · last yr.

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

Synaptic loss in schizophrenia isn't random. New PET imaging work from our group, led by @sidchop.bsky.social, shows it's left-lateralized, follows neurochemical gradients, and may propagate outward from inferior frontal cortex through axonal networks, independent of MRI grey matter changes

Sidhant Chopra@sidchop.bsky.social · last mo.

🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4

🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4

Widespread synaptic density loss in schizophrenia follows molecular and network architecture - Molecular Psychiatry

Molecular Psychiatry - Widespread synaptic density loss in schizophrenia follows molecular and network architecture

nature.com

Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health www.nature.com/articles/s44... With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel

Multiscale heterogeneity of atypical functional connectivity in autism - Nature Mental Health

Using normative modeling to measure the interindividual variability of atypical brain functional connectivity in autism, the authors identify heterogeneity at the level of specific connections alongsi...

nature.com

Great new stuff in @apertureohbm.bsky.social here 👇

Hallee Shearer@halleeshearer.bsky.social · 9mo ago

Excited to share our manuscript about BrainEffeX, a tool for exploring fMRI effect sizes. Includes why we made it, how to use it + contribute, and how we made it. @sneuroble.bsky.social @psychonetrics.bsky.social @alexkfischbach.bsky.social @nichols.bsky.social @dscheinost.bsky.social & MINDS Lab

Just published! 🎉 My new blog post tackles the mighty `apply()` function in R. Demystify `MARGIN` and master operations from matrices to 5D neuroimaging data. Say goodbye to loops! 🧠📊 drmo.site/k40xD5 #RStats #DataScience #Neuroimaging

Mastering Apply: From Matrices to Multidimensional Neuroimaging Data - Dr. Mowinckel’s

Master apply() in R for multidimensional data analysis.

drmo.site

Thrilled to share a new paper in @jamapsychiatry.com on path asymmetry in complex dynamic systems of psychopathology! jamanetwork.com/journals/jam... With amazing collaborators @tfblanken.bsky.social, Han van der Maas, & Denny Borsboom 🥳

Path Asymmetry in Complex Dynamic Systems of Psychopathology

This article illustrates the assumption of path symmetry in current theories of psychopathology and calls for the development of dynamical systems of mental illness that incorporate asymmetry.

jamanetwork.com

Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons | Nature Human Behaviour www.nature.com/articles/s41...

Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons - Nature Human Behaviour

Paluch et al. show that unattended working memory items, as well as attended ones, are encoded in persistent activity in the medial temporal lobe.

nature.com

Michael X Cohen on why he left academia/neuroscience. mikexcohen.substack.com/p/why-i-left...

Why I left academia and neuroscience

Don't worry, this isn't yet another story of rage-quitting.

mikexcohen.substack.com

When @laurapritschet.bsky.social & Pavel Shapturenka set out to build the 28&Me + 28&He datasets, I don't think any of us could've predicted the spectacularly creative ways the datasets would be used years later. That's the power of open science. 👇🏼

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025... Funded by National Institute of Mental Health (NIMH)

Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health

Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...

doi.org

Congratulations to these Orygen early career researchers, whose innovative work has been recognised with new grants 👏 More details: bit.ly/46BpOdj @sidchop.bsky.social @stephmiles.bsky.social

Hej, Melbourne #rstats folks! Please join me for my in-person workshop on C++ Programming for Faster Statistical Modelling in R on Monday, Sep 29! Lot's of goodies for econometricians and statisticians here! Register at: wombat2025.numbat.space #rstats #rcpp

WOMBAT 2025

The Annual Workshop Organised by the Monash Business Analytics Team will be held on the 29th and 30th September 2025 at Monash University (downtown), Melbourne, Australia.

wombat2025.numbat.space

WOMBAT 2026@wombat.numbat.space · 11mo ago

We're offering two hands-on tutorials on September 29th for those wanting to level up their software dev skills. Learn how to create your own #RStats packages in the morning, followed by an afternoon treat of C++. See the full program & register: wombat2025.numbat.space #WOMBAT2025 #DataScience

Neuromorphic hierarchical modular reservoirs | doi.org/10.1101/2025... How does hierarchical modularity shape computational function? ⤵️

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis | doi.org/10.1038/s420... How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️

in preparation for next week's NACS speaker, today's target article

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

The BRIDGE Lab has officially been launched! 🔗 bridgelab.ucsd.edu 👉 we Bridge Research in Imaging, Development, Genetics and Emerging mental health 🧠 🧬 🚸 🌉 please don't be shy to reach out if you are interested in learning more about our lab's research!

Our latest work is now out in @natmentalhealth.nature.com! We examined the role of the basal forebrain and its influence on intrinsic brain networks in depressive and anxiety disorders. 🔗 www.nature.com/articles/s44... @psychunimelb.bsky.social, @mbciu.bsky.social, #UnimelbMDHS

Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders - Nature Mental Health

Using 7T resting-state functional MRI data, the authors investigate the effective connectivity of basal forebrain areas in a transdiagnostic sample of patients with anxiety and depression and healthy ...

nature.com

🔍 OHBM's SIGs and Committees spotlight research reflecting the topics and challenges that matter to their communities. Explore their selections here: apertureneuro.org/pages/906-fe... @ohbmenvironment.bsky.social @ohbm-com.com @ohbmossig.bsky.social @ohbmofficial.bsky.social

🔥ATTENTION!🔥 Registration for the 2026 Noosa Brain Workshop is now open! Join us for some amazing science, sun, and surf in one of Australia's most beautiful beach towns. Details: tinyurl.com/arbc5pp6 Check out or incredible list of confirmed speakers. More to come...

The @cahbir.bsky.social and @rutgersbhi.bsky.social are hiring! Multiple open area and open rank faculty jobs, wonderful colleagues, amazing resources, and one of the largest communities of brain science research groups on the planet. Please apply and share widely. jobs.rutgers.edu/postings/209...

🧠 We're hiring a computational postdoc! 3+ years with me & @mitulamehta.bsky.social on @wellcometrust.bsky.social funded social cognition/paranoia research at the IoPPN. Lead & develop computational work, collaborate with experimentalists on psychosis/THC data. DM for details! lnkd.in/eCMy9Jf5

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

NIMH Data Archive is now also imposing NIST/ISO requirements (like NBDC). Not sure how many labs actually have the resources to meet these requirements. Is the golden era of open brain imaging data basically over?