The final piece of my PhD work is now published in Science Translational Medicine! We present a new framework to jointly infer epidemiological and antigenic parameters from multi-pathogen population serological studies🦠 www.science.org/stoken/autho...

📢 Thrilled to see that our work on chikungunya virus (CHIKV) epidemiology in Brazil is out in @thelancetinfdis.bsky.social 🧵

The Lancet Infectious Diseases@thelancetinfdis.bsky.social · 8mo ago

New Research The epidemiology of chikungunya virus in Brazil and the potential impact of vaccines: a mathematical modelling study www.thelancet.com/journals/lan...

📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬 Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨ Key findings in thread below 👇 www.biorxiv.org/content/10.1...

Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia

The release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...

biorxiv.org

🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.

🚨 Nipah virus poses a future #pandemic risk. New cases in Kerala, India further highlight the need for a One Health approach. Read more in our recent interdisciplinary and multi-institutional collaborative article now published in @NatureMicrobiology #LZCI : www.nature.com/articles/s41...

A One Health approach to understanding and managing Nipah virus outbreaks - Nature Microbiology

In this Perspective, Yadav et al. discuss NiV outbreaks, transmission cycles and the role of reservoir and bridging hosts. They also discuss a One Health approach to mitigate the risks of NiV epidemic...

nature.com

Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models. journals.plos.org/ploscompbiol...

RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies

Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...

journals.plos.org

Phylowave; The latest framework developed by researchers to identify more infectious variants of viruses or bacteria, including those responsible for flu, #COVID and whooping cough. "A vaccine can be specifically targeted against these variants, to make it as effective as possible" 🔗 rdcu.be/d5pFu

Great way to start the year! A paper in @nature.com by our amazing @noemie presenting a way to use sequences to identify pathogen lineages, quantify their fitness, and identify potentially important genes/snps . Works across bugs, even with minimally and biased set of sequences.

Noémie Lefrancq@noemielefrancq.bsky.social · 2y ago

Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 https://buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling

Great way to finish the year! Paper by our @huangat.bsky.social in @pnas.org showing that relying on seroconversions in cohorts will usually lead to horribly biased #dengue incidence estimates whereas models relying on age data from local hospital typically robust.

Angkana T. Huang (HAT)@huangat.bsky.social · 2y ago

No one best way to measure #infection risk in populations. Cross-sectional sero: weak temporal signal, CXR, waning as we know. Extra care needed for longitudinal #serology as Ab kinetics and assay noise can mess up estimates by a lot. Cases can be powerful! www.pnas.org/doi/10.1073/pnas.2411768121

Really excited by the creation of this new Unit with @ksbakes.bsky.social and @virologyhouldcroft.bsky.social working on the emergence, spread and control of infectious diseases at the University of Cambridge

Pathogen Dynamics Unit@pducambridge.bsky.social · 2y ago

Hello world! After a year in the making, the Pathogen Dynamics Unit is ready to launch! Check out our website (pdu.gen.cam.ac.uk) and follow the team (bsky.app/profile/did:...) to keep up with the latest from our infectious disease supergroup based at @geneticscam.bsky.social

Huge thanks to my supervisors Katie Hampson and Christina Cobbold, examiners @davidlrobertson.bsky.social and @hsalje.bsky.social and convener Louise Matthews!! And everyone else at UofG and beyond who have made the last 3.5 years an amazing time 😁🎉

School of Biodiversity One Health and Veterinary Medicine@sbohvm.gla.ac.uk · 2y ago

A big congratulations to Dr. Rowan Durrant (@rowandurrant.bsky.social) for successfully completing her viva yesterday! 📄Thesis: "Genetic analysis of the rabies virus" 🧬🦠

We are very proud to share that @hsalje.bsky.social has been awarded an #ERC Consolidator Grant 🎉 He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠

Could not be more deserved. Congratulations again Noémie.

Noémie Lefrancq@noemielefrancq.bsky.social · 2y ago

Thrilled to have received this award, thank you @gensocuk.bsky.social! Many thanks to @hsalje.bsky.social @julianparkhill.bsky.social, Sylvain Brisse and the amazing research groups without whom the work wouldn't have been possible!

#Measles antibody dynamics are highly predictive. Knowing only a future mum’s titre, we can predict how the infant will respond to vaccine much later. We also see vaccine failure linked to csection birth - maybe due to way microbiome develops. Important these infants get 2nd dose t.co/MqxTtuIHTH

Dynamics of measles immunity from birth and following vaccination - Nature Microbiology

Measles remains a major threat to human health despite widespread vaccination. While we know that maternal antibodies can impair vaccine-induced immunity, the relative contributions of pre-existing im...

t.co

New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China. @hsalje.bsky.social www.nature.com/articles/s41...

Dynamics of measles immunity from birth and following vaccination - Nature Microbiology

Serological data modelling informs on immune interference from maternal antibodies on measles vaccine responses in infants and children.

nature.com

Congratulations to our amazing DR. Megan O’Driscoll @meganodris.bsky.social on successfully passing her PhD viva! State of the art in infectious disease serology. Thank you to Michael White and Stephen Baker for being excellent examiners.

We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa. jobs.cam.ac.uk/job/44461/

Excited to present our poster on the genetic diversity of Nipah virus later today at Epidemics9 - Come say hi at poster P2.167! 🦇🧪#EpiSky @hsalje.bsky.social

🧪Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t @thelonevirologist.bsky.social www.nature.com/articles/s41...

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting - Nature

Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multi...

nature.com

The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫

The evolution and international spread of extensively drug resistant Shigella sonnei - Nature Commun...

An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, t...

nature.com