UCSF Bakar ImmunoX Initiative

@immunox.bsky.social

First-in-class program nucleating #immunology research at UCSF to treat human diseases.

A UCSF & @ucberkeleyofficial.bsky.social AI model could help doctors spot women at high risk for breast cancer faster, cutting time from screening to diagnosis. “This is a powerful example of how AI can be a collaborative partner for physicians,” researcher Adam Yala says. https://ucsfh.org/43WEqTq

How New AI Cuts Breast Cancer Screening Time for High-Risk Women

Using AI on mammograms can identify patients at highest risk for breast cancer and get them same-day follow up care, eliminating stressful waiting times.

ucsfh.org

By spurring the body to fight hepatitis B on its own, "helper" immune cells may be the secret to curing the virus, a @science.org study finds. “We think this could lead to much better treatments based on the liver’s natural biology," Dr. Jody Baron says. https://ucsfh.org/4dotl3f

The Liver’s Immune Cells Might Be the Key to Curing Hepatitis B

Jody Baron and Gabi Fragiadakis discover why some people with chronic Hepatitis B are cured after they're taken off of antiviral drugs, despite falling severely ill when the drug regiment stops.

ucsfh.org

Macrophages undertake a non-destructive, direct sampling of living cells via trogocytosis-like stretching of the target cell & acquisition of submicrometre-sized cytoplasmic vesicles @nature.com @immunox.bsky.social @maxkrummel.bsky.social @amycfanphd.bsky.social www.nature.com/articles/s41...

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Amy C Fan (she/her)@amycfanphd.bsky.social · 3mo ago

Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social

A recent UCSF Turnbaugh Lab study found that certain gut bacteria may influence how patients tolerate the chemo drug capecitabine (CAP). Scarlett Yang spoke with Kai Trepka and Dr. Peter Turnbaugh about how this discovery could reshape the way we approach cancer care. Learn more below!

Blue background with floating blue and pink cells. ImmunoX logo centered at the bottom. A navy box below reads: ‘Science is for everyone. Breaking Down Biology Blog.’Capecitabine, a chemotherapy drug, changes the gut microbiome (the ecosystem of microbes in the gut). It is found to increase the number of Vitamin K2-producing E.coli (a type of bacteria), which may be associated with protecting the gut microbiome and relieving chemotherapy side effects.

🫀How does chronic cannabis use affect your vascular health? To explore this question, Soham Ray, MSc, sat down with Drs. Leila Mohammadi, MD, PhD, and Matt Springer, PhD. Click the links below to learn what their conversation uncovered about risks, insights, and future directions.

Blue background with floating blue and pink cells. ImmunoX logo centered at the bottom. A navy box below reads: ‘Science is for everyone. Breaking Down Biology Blog.’An infographic titled “Impact of Chronic Cannabis Use on Vascular Health” shows three blood vessels side by side:

None (baseline/healthy): The leftmost vessel is wide with many healthy red blood cells flowing smoothly, representing normal endothelial function and vascular health.

Occasional: The middle vessel remains open with red blood cells flowing, showing no detectable long-term dysfunction from occasional cannabis use.

Frequent: The rightmost vessel is narrowed with fewer red blood cells passing through, illustrating endothelial dysfunction and impaired vascular health associated with chronic cannabis use.

The caption at the bottom notes: “Cannabis Smoking and THC-Edible Use Frequency.”

What if the uterus has a molecular clock to measure pregnancy length? Drs. Tara McIntyre and Adrian Erlebacher discuss their gene-regulation ‘timer’ discovery in mice with Alessandra Veinbachs. Click the links below to learn how this mechanism could reshape our understanding of gestational timing.

Blue background with floating blue and pink cells. ImmunoX logo centered at the bottom. A navy box below reads: ‘Science is for everyone. Breaking Down Biology Blog.’Schematic showing a molecular mechanism in the uterus of a mouse: To test the role of KDM6B (and gene regulation more generally) in determining labor timing, the researchers created mice that lacked the histone demethylase KDM6B in cells of the uterus called uterine fibroblasts. They found that, compared to control mice, those lacking KDM6B had a delayed drop in P4 and gave birth several days later. This suggested that without KDM6B, the uterus was unable to activate the gene program required to initiate labor at the proper time.

Congratulations to our very own professor of chemistry, @jenniferdoudna.bsky.social, on being awarded the Priestley Medal! 🏅

C&EN (Chemical & Engineering News)@cenmag.bsky.social · last yr.

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

We're so excited for our upcoming Computational Biology Initiative Hackathon on Thursday August 7th and Friday August 8th, 2025 where teams will work together to analyze the complex phenotypes of an inflammatory disease using single-cell sequencing data from human samples. Stay tuned for updates!

Three researchers collaborating at a previous ImmunoX Computational Biology Initiative (ICBI) Hackathon. They are gathered around a computer, looking at a dataset on the screen while one points at it.

CoProjects unite our community to study the immune system across diseases—sharing samples, data & tools to accelerate discovery. We're excited to announce the next group of funded projects & investigators! Learn more about this year's projects on our Instagram, @ucsf_immunox.

Graphic with a dark purple background and a transparent white rectangle centered. Inside the rectangle: the CoProjects logo at the top, followed by three rows of headshots of award recipients, and the Bakar ImmunoX logo at the bottom.

First row (L to R): Andrei Goga (MD, PhD), Joel Ernst (MD), Matt Kutys (PhD)

Second Row (L to R): Trevor Fidler (PhD), Peter Bruno (PhD), Adam Oskowitz (MD, PhD)

Third Row (L to R): Chris Allen (PhD), Mark Ansel (PhD), Monica Tang (MD)

Visit our Instagram for more information about their projects: @ucsf_immunox

For more information about the ImmunoX CoProjects, check out our website: immunox.ucsf.edu/coprojects

At UCSF, ImmunoX brings scientists, doctors, and students together to share ideas and improve health. With over 140 faculty and 500 trainees across many disciplines, we’re growing fast and collaborating locally and globally. We’re excited to share more about our people and the impact of our work.

Group of physicians gathered and looking at a computer. There's a pink text box in the top left corner that reads: 'Harnessing immunology to improve human health'.