July's featured article from our exchange with @discovimmunol.bsky.social investigates the immunomodulatory capacity of various arginine-related metabolites. academic.oup.com/discovimmuno...

Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation

AbstractIntroduction. Cell metabolism plays an important role in immune effector responses and through responding to metabolic signals, immune cells can ad

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ICB - the journal@immunolcellbiol.bsky.social · last yr.

What can we learn about airway resident memory T cells from pig models? Plenty! Find out more in this month's @discovimmunol.bsky.social Outstanding Article

This is a great new study showing in Crohn’s disease, aphthous ulcers trigger immune responses via bacterial uptake, not dysbiosis This is part of the article exchange between the BSI's @discovimmunol.bsky.social and the @immunolcellbiol.bsky.social

Discovery Immunology@discovimmunol.bsky.social · last yr.

This month’s article exchange with @immunolcellbiol.bsky.social: New study shows that in Crohn’s disease, aphthous ulcers trigger immune responses via bacterial uptake, not dysbiosis. Peyer’s patches may be the ignition site 🧬 Read here: doi.org/10.1111/imcb... #Crohns #Immunology

This month’s article exchange with @immunolcellbiol.bsky.social: New study shows that in Crohn’s disease, aphthous ulcers trigger immune responses via bacterial uptake, not dysbiosis. Peyer’s patches may be the ignition site 🧬 Read here: doi.org/10.1111/imcb... #Crohns #Immunology

What can we learn about airway resident memory T cells from pig models? Plenty! Find out more in this month's @discovimmunol.bsky.social Outstanding Article

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Abstract. Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by

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ICB - the journal@immunolcellbiol.bsky.social · last yr.

May's featured article in our exchange with @discovimmunol.bsky.social reveals altered spatial distribution of ILCs in #endometriosis and suggests the primary role of uterine ILC3 may be endometrial repair and regeneration.

For this month’s article exchange with @immunolcellbiol.bsky.social: Genetic analysis causally links 22 immune cell types to PCOS. Blood metabolites mediate several effects, offering new insight into how immunity and metabolism shape disease. 🔗 doi.org/10.1111/imcb...

May's featured article in our exchange with @discovimmunol.bsky.social reveals altered spatial distribution of ILCs in #endometriosis and suggests the primary role of uterine ILC3 may be endometrial repair and regeneration.

Dynamic roles of ILC3 in endometrial repair and regeneration

AbstractBackground. Innate lymphoid cells (ILCs) are prominent in the human uterine mucosa and play physiological roles in pregnancy. ILC3 are the second-m

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ICB - the journal@immunolcellbiol.bsky.social · last yr.

Our April article exchange with @discovimmunol.bsky.social features a study on the relative contribution of CD28 and TCR signals on human naive and memory T cells. academic.oup.com/discovimmuno...

Our @immunolcellbiol.bsky.social "Highlights of 2024: Germinal Centers" is now out. Led by Theresa Pankhurst, we discuss some (there's never enough space for all!) neat germinal centre papers that were published in 2024, and whose findings are moving the field forward. doi.org/10.1111/imcb...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this article for the Highlights of 2024 series, we review the latest advances in the biology of the germinal center response. These discoveries provide key insights into germinal center function a...

doi.org

For this month's article exchange with @immunolcellbiol.bsky.social we're highlighting "Notch dependent chromatin remodelling enables Gata3 binding and drives lineage specific CD8+ T cell function." A study on how Notch signalling primes antiviral CD8+ T cell responses. 📖 doi.org/10.1111/imcb...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

This study examines how Notch signaling conditions the genome landscape within activated CD8+ T cells in such a way to alter the binding pattern of transcription factors such as Gata3. This Notch dep...

doi.org

Our April article exchange with @discovimmunol.bsky.social features a study on the relative contribution of CD28 and TCR signals on human naive and memory T cells. academic.oup.com/discovimmuno...

CD28 and TCR differentially impact Naïve and Memory T cell responses

Abstract. Manipulating CD28 co-stimulation is a key element of anti-tumour immune responses and treating autoimmune diseases. CD28 can reduce the T cell ac

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ICB - the journal@immunolcellbiol.bsky.social · last yr.

To what extent do different practices of microbial exposure affect resulting mouse phenotypes? March's Outstanding article from @discovimmunol.bsky.social shows a side-by-side comparison, enhancing understanding of naturalisation model setups and effects on the gut barrier and immune system

Great new article out led by @stevipiliou.bsky.social on improving accessibility to neuroimmunology for the blind and low-vision communities! @immunolcellbiol.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

The Sensory Science exhibition, held during March 2024, was a collaborative effort between researchers and artists, aimed to promote the importance of inclusive and diverse scientific engagement for ....

onlinelibrary.wiley.com

"Your career is more than just your technical expertise—the skills, interests and motivations that make you unique, both inside and outside of research, can shape your path in unexpected ways." Dr Amy Wilson from @ocrfaustralia.bsky.social reflects on moving into a research advisor role

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

Amy Wilson, a Research Advisor for the Ovarian Cancer Research Foundation (OCRF) and an Honorary Research Associate at the Hudson Institute of Medical Research, began her career as a postdoctoral res....

onlinelibrary.wiley.com

For this month's article exchange with @immunolcellbiol.bsky.social, we're highlighting 'Refining bone marrow ablation and reconstitution in mice.' by Penny Hawkins, James Dooley, Jessica Rodda and Colin Gilbert. 🔎 Read here: doi.org/10.1111/imcb.12847

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

Bone marrow ablation and reconstitution are commonly used procedures in research that are often associated with significant suffering for the animals involved, classified as ‘severe’, Category E or C...

onlinelibrary.wiley.com

To what extent do different practices of microbial exposure affect resulting mouse phenotypes? March's Outstanding article from @discovimmunol.bsky.social shows a side-by-side comparison, enhancing understanding of naturalisation model setups and effects on the gut barrier and immune system

Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience

AbstractIntroduction. Concerns regarding the translational value of preclinical mouse models have been addressed by introducing various approaches of ‘natu

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ICB - the journal@immunolcellbiol.bsky.social · last yr.

Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.

Are you ready for it? "Highlights of 2024: γδ T cells and bad blood" A summary of the emerging regulatory and effector roles of #gdTcells in #sepsis. And it may also contain a few Taylor Swift references. More than 50 in fact. Thank you so much @immunolcellbiol.bsky.social for playing along!

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this manuscript for the “Highlights of 2024” series, this is me trying to summarize recent discoveries regarding the emerging regulatory and effector roles of γδ T cells during sepsis, both in hum....

onlinelibrary.wiley.com

From pipettes to playdates! @rhea-longley.bsky.social et al. share challenges and successes from establishing a parent support group in a research setting.

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this article, we discuss the conceptualization, formation and management of our workplace Parents Group. We honestly reflect on both our successes and challenges. Graphic from Vivienne Samson (age....

onlinelibrary.wiley.com

Our new special feature is out now! From reflections on starting a parents group for researchers to a case study on Indigenous student engagement in science, this special feature amplifies intersectional discussions on diversity, equity, and inclusion in healthcare and STEMM. bit.ly/41JpXKa

This article from our upcoming special feature on Advancing Equity and Inclusion in Healthcare highlights the work of Immunologists for Gender Equity (IgEquity), a trainee-led organisation at @immunox.bsky.social. #InternationalWomensDay

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

This article highlights the work of our trainee-led organization, Immunologists for Gender Equity (IgEquity), which addresses gender inequities in Immunology through initiatives focused on community ....

onlinelibrary.wiley.com

Our paper is finally out in @immunolcellbiol.bsky.social, think that transcription factor expression is all that? Well not if the genome is not prepared in a way to allow binding: here is a short 🧵1/

For this month's article exchange with @immunolcellbiol.bsky.social, we're highlighting 'Exploring the dynamics of T-cell responses: a combined approach using EdU incorporation and proliferation dye dilution assay' by @jfreenvanheeren.bsky.social and colleagues 🔎 Read here: doi.org/10.1111/imcb...

Obesity is associated with increased susceptibility to infection, which may be due to obesity-induced immune dysregulation. The latest article exchange highlight from @discovimmunol.bsky.social looks at dendritic cell responses to Sendai Virus in a mouse model of diet-induced obesity.

Obesity drives dysregulation in DC responses to viral infection

AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

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ICB - the journal@immunolcellbiol.bsky.social · 2y ago

January's article exchange highlight from @discovimmunol.bsky.social investigates evolutionary advantages of PD-1, which could help uncover mechanisms of immune-related adverse events associated with PD-1 blockade #immunotherapy academic.oup.com/discovimmuno...

Self-reactive B cells are increased in all major stages of peripheral development in Sjögren's disease. This study from Lee et al. suggests that depleting self-reactive B cells based on B cell receptor specificity would be more efficient than targeting developmental stage in Sjögren's disease.

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this article, we identify self-reactive peripheral blood B cells in Sjögren's disease through a single-cell culture system. We find 2- to 10-fold increased frequencies of self-reactive B cells dur...

onlinelibrary.wiley.com

Thanks @immunolcellbiol.bsky.social for inviting Menno and I to write this commentary about the @bogunoviclab.bsky.social paper in @nature.com on monoallelic allele expression in inborn errors of immunity Monash Immunology and Erasmus MC #immunosky doi.org/10.1111/imcb...

If any American immunologists want to write an op-ed for @immunolcellbiol.bsky.social on the impact of the new executive orders, please contact me

Modeling the response to interleukin-21 to inform natural killer cell immunotherapy

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this study, we investigated multiple cytokine combinations to boost natural killer (NK) cell proliferation as well as effector functions of proliferated NK cells against hepatocellular carcinoma a...

onlinelibrary.wiley.com

Also, the submission and editorial experience with @immunolcellbiol.bsky.social was fantastic, highly efficient, very professional, and yes I am an #AusNZSocImmunol member, but if you are looking for somewhere to publish #immunologyiscool work, can't recommend highly enough.

So many good reasons to publish in ICB!

Ten years away from “home” as a South American immunologist in Ireland: Dr Natalia Muñoz-Wolf shares insights on pursuing an international scientific career in this #ImmunologyFutures article

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

This manuscript, part of the Special Series “Focus on South American immunology”, provides a personal reflection on the challenges and opportunities I have encountered during my journey as an immunol...

onlinelibrary.wiley.com

As part of our article exchange with @immunolcellbiol.bsky.social, this month we're highlighting the article 'Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy' Read the article exploring immune response after anti-CD19 #CAR-T therapy here: doi.org/10.1111/imcb...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

In this study, we investigated the longitudinal dynamics and clonal expansion of circulating γδ T cells in four patients receiving anti-CD19 CAR-T cell therapy. Using single cell multi-omics analysis....

doi.org

January's article exchange highlight from @discovimmunol.bsky.social investigates evolutionary advantages of PD-1, which could help uncover mechanisms of immune-related adverse events associated with PD-1 blockade #immunotherapy academic.oup.com/discovimmuno...

Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by de novo genome mutagenesis

AbstractIntroduction. Programmed death-1 (PD-1) is a negative regulator of immune responses. Upon deletion of PD-1 in mice, symptoms of autoimmunity develo

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ICB - the journal@immunolcellbiol.bsky.social · 2y ago

We're collaborating with @discovimmunol.bsky.social and @britsocimm.bsky.social to promote great science! December's Outstanding Article explores metabolic regulators of T cell migration and cytokine production. #ImmunoSky

Review: Chemokines and their receptors in the pathogenesis and treatment of #neurodegeneration and #neuroinflammation disorders

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library

This review discusses the dysregulation of several members of chemokines that have been reported in the CNS, cerebrospinal fluid and peripheral blood of patients with neurodegenerative disorders. Upo....

onlinelibrary.wiley.com