New research emerging from the COVID-19 pandemic is revealing surprising connections between viruses, inflammation, and cancer progression. Gladstone Investigator Melanie Ott comments on these findings in the LA Times. @theottlab.bsky.social

What COVID is teaching doctors about the relationship between viruses and cancer

The pandemic has left some evidence that viral infection may play a role in reawakening dormant cancer cells already present in a patient's body before infection.

latimes.com

A team of Gladstone scientists—including Katie Pollard, Melanie Ott, Seth Shipman, and Sukrit Silas—will lead one of three new national centers dedicated to accelerating the development of phage therapy. @theottlab.bsky.social @seth-shipman.bsky.social

Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections

The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.

gladstone.org

We're launching a major collaborative Center aimed at accelerating phage therapy @gladstoneinst.bsky.social. High-throughput experiments with engineered phages (my lab) and strains (Silas Lab), organoids (Ott Lab), and AI (Pollard Lab). gladstone.org/news/gladsto...

Gladstone Launches Center for PhAIge Therapy to Harness AI in the Fight Against Drug-Resistant Infections

The center, funded by an NIH grant, will become one of three national centers dedicated to accelerating the development of phage therapy.

gladstone.org

🚨 NEW PUBLICATION🚨 "Programmable kinetic barcoding for multiplexed RNA detection with Cas13a" @natbiomedeng.nature.com @doudna-lab.bsky.social @theottlab.bsky.social https://www.nature.com/articles/s41551-026-01642-6

Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering

A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...

nature.com

Cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound after ART interruption @cp-immunity.bsky.social @gladstoneinst.bsky.social #Roan @theottlab.bsky.social #Greene www.cell.com/immunity/ful...

In our new work published in @natbiomedeng.nature.com in collaboration with @theottlab.bsky.social and @doudna-lab.bsky.social, we introduce "interfering" guide RNAs (igRNA) for CRISPR-Cas13a that regulate enzyme activity after activation. Congrats to all the authors! www.nature.com/articles/s41...

Programmable kinetic barcoding for multiplexed RNA detection with Cas13a - Nature Biomedical Engineering

A multiplexed RNA detection method exploits crRNA-dependent variability in Cas13a activity on RNA targets for kinetic barcoding and can be used to distinguish among SARS-CoV-2 variants in clinical sam...

nature.com

We honor the life of J. Michael Bishop, whose groundbreaking discoveries helped transform our understanding of cancer and opened new paths for treatment. His legacy will continue to inspire generations of scientists and clinicians. Rest in peace.

Antiretroviral therapy transformed #HIV care—now we need a cure. Insights from Melanie Ott on what comes next.

Virologist Viewpoints: For HIV, ‘Manageable' Is No Longer Good Enough

Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS.

bit.ly

Congrats, Nadia!

Gladstone Institutes@gladstoneinst.bsky.social · 6mo ago

Nadia Roan, a pioneer in the fight against some of the world’s most persistent viruses, has been elected as a 2026 Fellow of the American Academy of Microbiology.

🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...

bit.ly

Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"! 📆 Monday, December 1, 2025 at 10am PT 📍 Live on TikTok via @RaifDerrazi 🔗 Register: tiktok.com/live/event/7...

The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-...

Beyond Viruses: Expanding the Fight Against Infectious Diseases

The newly renamed Gladstone Infectious Disease Institute broadens its mission to address global health threats ranging from antibiotic resistance to infections that cause chronic diseases.

gladstone.org

Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025...

With vaccine research under attack, it’s time for California to lead again

Halting mRNA research right now is like banning ChatGPT, writes infectious disease expert Melanie Ott — not just scientific negligence, but strategic self-sabotage.

sfstandard.com

💉🧬 We're kicking off National Immunization Awareness Month with our faculty spotlight, Dr. Melanie Ott! Head to our Instagram to hear her take on how immunizations keep us safe—and how you can help to keep vaccines accessible for all: www.instagram.com/reel/DM_A9Sc... @theottlab.bsky.social

Congratulations Fran! @franzapatero.bsky.social

amfAR@amfarofficial.bsky.social · last yr.

Meet amfAR’s 2025 Mathilde Krim Fellows: Drs. Hastie, King, Ou & Zapatero Belinchon. As HIV research faces steep NIH cuts, amfAR is proud to back these bold young scientists and their innovative ideas. Learn more: www.amfar.org/news/new-amf...

Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award! cfar.ucsf.edu/user/11703

We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXu...

Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics. @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social

Discovery Spotlight | Could This Molecule Be ‘Checkmate’ for Coronaviruses?

Scientists from Gladstone and UCSF have developed drug candidates that could prevent future coronavirus pandemics. These molecules block a critical enzyme ne...

youtube.com

Scientists develop powerful drug candidates that could head off future coronavirus pandemics. @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social

Could This Molecule Be ‘Checkmate’ for Coronaviruses?

Scientists develop powerful drug candidates that could head off future coronavirus pandemics.

gladstone.org

🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy" @theottlab.bsky.social @ucsfmedicine.bsky.social @qbi-ucsf.bsky.social

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

This study describes a class of potent, bioavailable SARS-CoV-2 MPro inhibitors having an unusual mechanism of inhibition.

science.org

🎧 Listen to this podcast featuring virologist Melanie Ott. Ott discusses how measles works and the way it breaks into our body to make us sick. @theottlab.bsky.social

How does measles make us sick?

And the damage left in its wake...

bit.ly

Thank you to everyone who attended the HIV Mini-Symposium on March 13th! Our next Mini-Symposium will be September 23, 2025 titled 'Viral Landscapes: How to Comprehensively Monitor Evolutionary Trajectories'. We hope to see you there! www.youtube.com/watch?v=vjpe...

HIV Persistence: Where We Are Now and Where We Need to Go

YouTube video by QBI TV

youtube.com

Did you know that viruses don’t just infect humans—they also target bacteria in our microbiome? These viruses, called phages, play a crucial role in shaping our health and could be the key to fighting antibiotic-resistant bacteria. In this short, @theottlab.bsky.social explains.

Virologist Melanie Ott (@theottlab.bsky.social) speaks to KUSI News about the measles outbreak and other infectious diseases.

Gladstone's Dr. Melanie Ott speaks about measles, other infectious diseases on KUSI

buff.ly

At Gladstone, researchers are working toward curing HIV for good. Their work also sheds light on how viruses influence our long-term health. Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology explains why curing HIV remains a crucial scientific challenge. @theottlab.bsky.social

What does the bird flu outbreak mean for public health? Virologist Melanie Ott (@theottlab.bsky.social) discusses how H5N1 in cows could affect virus evolution and why increased surveillance is important.

How Bird Flu in Cows Could Impact Public Health | Melanie Ott Explains

What does the bird flu outbreak mean for public health? Melanie Ott, MD, PhD, director of the Gladstone Institute of Virology, discusses how H5N1 in cows cou...

youtube.com

Melanie Ott talks about the ongoing measles outbreak, explains how vaccination can lower the risk of Alzheimer’s, and shares other positive “side effects” of vaccines. @theottlab.bsky.social

Virologist Viewpoints: The Positive Side Effects of Vaccines

Melanie Ott talks about the ongoing measles outbreak, explains how vaccination can lower the risk of Alzheimer’s, and shares other positive “side effects” of vaccines.

gladstone.org

In an interview with @amfarofficial.bsky.social, Melanie Ott (@theottlab.bsky.social), discusses the future of HIV research, and describes how lessons from the field have laid a strong foundation for fighting other viral diseases.

Shaping the Future of HIV Research

amfAR interviewed Gladstone Institutes’ Dr. Melanie Ott about her work on HIV, hepatitis C, and other viruses, and the promise of new technologies.

amfar.org

Gladstone recently hosted the German Center for Research and Innovation San Francisco for their Innovation Summit. The event addressed the challenge of sharing data across sectors, institutions, and borders, a key question for global health. Speakers included Melanie Ott (@theottlab.bsky.social)

HIV research has led to breakthroughs in antiviral treatments & cancer therapies. amfAR’s Dr. Andrea Gramatica & Dr. Melanie Ott (@theottlab.bsky.social) discuss how investing in one virus drives medical innovation. www.amfar.org/news/shaping...

Shaping the Future of HIV

amfAR interviewed Gladstone Institutes’ Dr. Melanie Ott about her work on HIV, hepatitis C, and other viruses, and the promise of new technologies.

amfar.org