Check out our latest #biorxiv #preprint on #chitin oligomers inducing #NLRP3 #inflammasome activation and trained innate immunity via #TLR2 👉https://www.biorxiv.org/content/10.64898/2026.06.19.733345v1.full.pdf+html

🚨Novel Concepts in #Innate_Immunity #conference (NCII) 18-20 May 2027 speaker list is out: 🚨 Join us @uni_tue also to hear @giedretamulaitiene.bsky.social @reisesousalab.bsky.social, @immunobladder.bsky.social! Link 👉https://innate-immunity-conference.de/programme-abstracts/confirmed-speaker

🚨Novel Concepts in #Innate_Immunity #conference (NCII) 18-20 May 2027 speaker list is out: 🚨 Join us @uni_tue to hear @audeber.bsky.social, @drusqui.bsky.social @soyonhonglab.bsky.social, @laemmermann-lab.bsky.social, @manellab.bsky.social, @v-hornung.bsky.social and many others! Link👇

Finally out @NatureComms: our latest study on #NLRP3 #inflammasome pathways. Here, we describe an oligomer-/MTOC-independent pathway that dominates in primary human #neutrophils. Special thanks to Maria Mateo Tortola, Ana Tapia Abellan, and great additional collaborators! Link👇

Exciting new insights into zebrafish #NLRP3 structure: an exciting novel 'cage' and new implications for #inflammsame activation mechanisms across species. Well done, Andreeva lab @uni_tue / @uktuebingen @CoE_ifit, fantastic work! Check it out👇

New #research just out: unique structural features in the #probiotic E. coli Nissle 1917 flagellin hypervariable region are vital for optimal motility in certain environments but apparently less for #TLR5 innate #immunity recognition. Check out the whole story 👇

New interesting #conference on "Mechanobiology in #Infection" at Ascona, Switzerland from June 7-11, 2026

New mechanistic insights on an old but fundamental mystery in innate immunity: how the #NLRP3 #inflammasome senses efflux of intracellular potassium ions - check out our new #biorxiv #preprint👇here: www.biorxiv.org/content/10.6...

CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation https://www.biorxiv.org/content/10.64898/2026.02.26.708242v1

Interested in the #NLRP3 #inflammasome in #neutrophils? Check out our recent review on this topic...: doi.org/10.1093/jleu...

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation

Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

doi.org

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

sciencedirect.com

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer @natcomms.nature.com nature.com/articles/s41...

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...