Ioana Olan
@iolan.bsky.social
Computational Biologist in the Narita Lab, CRUK CI and CRA at Homerton College, University of Cambridge. 🩷 🐈🐈⬛🧶🧮💻🧬🧪🧫🔭
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇
Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ? Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...
Mechanisms of gene regulation by SRCAP and H2A.Z - Nature Communications
SRCAP depletion causes rapid replacement of H2A.Z by H2A, leading to upregulation of lineage-specific transcription factors. SRCAP also prevents pioneer transcription factor binding by steric hindranc...
nature.com
Delighted to see this published: H3K115 acetylation is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. Great work from all contributors; Yatendra Kumar, @illingworth-lab.bsky.social @eliasfriman.bsky.social @helink.bsky.social doi.org/10.7554/eLif...
Congratulations @atjanowska.bsky.social 💐🎉💯👏
a penguin cheering with the words congratulations written above it
ALT: a penguin cheering with the words congratulations written above it
media.tenor.com
Narita Lab@narita-lab.bsky.social · 6mo agoCongratulations 🎉👏 to 🌟 Aleksandra 🌟 @atjanowska.bsky.social for passing her PhD viva today. Many thanks to her examiners, Prof. Jason Carroll and Prof. Jesus Gil for taking the time to assess her work and offer their feedback. We wish her a very successful and bright future ahead 🍀🍀🍀
#February is here! And with it, our #ImageoftheMonth: My Mitochondrial Romance, by Pilar Padilla (Complex Metabolic Diseases and Mitochondria Lab, IRB Barcelona). The image shows #mitochondria inside human skin fibroblasts, revealed by immunofluorescence. Happy February everyone! 🧪🐡
New study led by Prof. Daniel Munoz-Espin in collaboration with Prof. James Brenton's and our lab 🚨🚨🚨 www.nature.com/articles/s43...
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome - Nature Aging
González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated...
nature.com
