Congratulations to Raffaele Iannuzzi (our former PhD student) on his new role as Bioinformatician at TheraMe! We are delighted to see you begin this exciting new chapter and wish you every success in the journey ahead. With warmest wishes from everyone at the @ioriolab.bsky.social! 🎉

Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at @febsletters.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Held on 20 November 2025 at Human Technopole in Milan, the 2nd European Cancer Dependency Map Symposium convened experimental and computational scientists to discuss how cancer dependency mapping in ...

febs.onlinelibrary.wiley.com

Insights from the 2nd EuroDepMap Symposium are now out in FEBS Letters. Last November at Human Technopole researchers in cancer functional genomics and computational biology discussed challenges and future directions in mapping cancer vulnerabilities and building predictive frameworks. Link ⬇️

𝗧𝘄𝗼 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 analyses, 𝗼𝗻𝗲 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗶𝗻𝗴 𝘀𝘁𝗼𝗿𝘆: here is 𝗈𝗎𝗋 𝗇𝖾𝗐 𝗌𝗍𝗎𝖽𝗒, 𝗋𝖾𝗅𝖾𝖺𝗌𝖾𝖽 𝖺𝗅𝗈𝗇𝗀𝗌𝗂𝖽𝖾 𝖺𝗇 𝗂𝗇𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝗍 𝗐𝗈𝗋𝗄 𝖿𝗋𝗈𝗆 𝗍𝗁𝖾 𝗖𝗶𝗿𝗶𝗲𝗹𝗹𝗼 𝗴𝗿𝗼𝘂𝗽 (𝗦𝗲𝘀𝗶𝗮 𝗲𝘁 𝗮𝗹.), 𝗐𝗁𝖾𝗋𝖾 𝖢𝖱𝖨𝖲𝖯𝖱 𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝖼𝗒 𝗆𝖺𝗉𝗌 𝖺𝗋𝖾 𝗎𝗌𝖾𝖽 𝗍𝗈 𝗍𝖺𝖼𝗄𝗅𝖾 𝗍𝗁𝖾 𝗌𝖺𝗆𝖾 𝖼𝗁𝖺𝗅𝗅𝖾𝗇𝗀𝖾: 𝗆𝖺𝗄𝗂𝗇𝗀 𝗌𝖾𝗇𝗌𝖾 𝗈𝖿 𝖼𝖺𝗇𝖼𝖾𝗋 𝘷𝘢𝘳𝘪𝘢𝘯𝘵𝘴 𝘰𝘧 𝘶𝘯𝘬𝘯𝘰𝘸𝘯 𝘴𝘪𝘨𝘯𝘪𝘧𝘪𝘤𝘢𝘯𝘤𝘦 using DepMap data. Links 👇

Festive vibes in Iorio Lab today: we spiced up the weekly lab meeting with a Secret Santa. Great company, fun gifts and a brief break from pipettes and plots!

@eurocancerdepmap.bsky.social, hosted by Francesco (alongside Pedro Beltrao from ETH Zurich, and Evangelia Petsalaki and Isidro Cortés-Ciriano from EMBL-EBI) at @humantechnopole.bsky.social, has concluded. Great speakers delivered breakthroughs that advance #cancer genomics across #Europe! 🏛️🧬

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses

The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!

@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer

We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.

The Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.

Kudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.

Our very own Raffaele Iannuzzi successfully defended his PhD Thesis last week. Raf has worked on benchmarking CRISPRdata analytical tool and predictive models leveraging bulk & single cell RNA-seq data. We will definitely miss him. We wish him all the best as new adventures await! Congrats Raf! 🎉

!!! Less than 2 weeks left to register !!! Join us in Milan for the 2nd European Cancer Dependency Map Symposium, taking place on 20 November 2025 at Human Technopole Cancer functional genomics; CRISPR-based screening; AIdriven targetDiscovery and drug development humantechnopole.it/en/trainings...

Last week we had the pleasure of hosting @maxbillmann.bsky.social at @humantechnopole.bsky.social for an inspiring seminar on genetic interaction maps an networks. Fantastic to learn how CRISPR screens and integrative analyses can illuminate the logic of genetic dependencies. A big thank you Max 👏

Kudos to Yasin Ilkagan Tepeli for defending his PhD at TU Delft (June 2025)! During his PhD at goncalveslab.tudelft.nl, he visited our lab working on Oncostratifier for oncogene-addicted cohort stratification and therapeutic target prediction.

Francesco will be speaking at the High-Content CRISPR Screening conference, taking place March 18–19, 2026 in Vienna 🇦🇹 alongside leading experts in CRISPR screening, functional genomics, and drug discovery www.linkedin.com/posts/myllia...

The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open! Secure your spot via the conference website...

The registration and abstract submission for the "High-Content CRISPR Screening" conference on March 18–19, 2026, in Vienna, Austria is now open! Secure your spot via the conference website: https://...

linkedin.com

🚨 We’re hiring! 🚨 looking for a computational postdoc to lead an exciting project at the intersection of AI, CRISPR, multi-omics, and cancer genomics. Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities www.linkedin.com/jobs/view/42...