She never lived to see this moment, but it’s worth remembering that none of this would have happened without Virginia Giuffre. She had the courage to speak out against power and privilege when it was just her word against Andrew’s. Thanks to her, justice & accountability may finally have its day.

We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis

Next we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery

@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer

And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!

@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.

Brittany Trang@brittanytrang.com · 11mo ago

A Sharon Begley byline, almost 5 years after her death. Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written." Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating. 🧪🧬🧫

🚨 THIS IS NOT A DRILL 🚨 We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur… beta.ideas.lego.com/product-idea...

CUH Cancer Support Service are teaming up with local organisations to run a #MentalHealthAwarenessWeek Wellbeing Event on the 16 May at the Cambridge Cancer Help Centre, CB22 5JT. 💚 Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk

@dereklowe.bsky.social puts it perfectly yet again! #facepalm #AI #machinelearning #dontbelievethehype

Derek Lowe@dereklowe.bsky.social · last yr.

Thoughts on Demis Hassabis of Google DeepMind saying that AI could cure disease in general in ten years. Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!

No one realized it until recently, but a new drug was forming inside some of the patient-controlled-anaesthesia pumps used in hospitals. Beware the Mannich condensation:

Metamorphine, An Unwelcome Product

science.org

Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women. More women are murdered in the perinatal period than die of obstetric complications. I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.

If this story checks out according to the below, it is insane and shameful. As I asked on the blog the other day: "What are we turning into?"

Paul Cohen@paulecohen.bsky.social · 2y ago

Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated

If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!

Cancer Research UK@cancerresearchuk.org · 2y ago

Just announced! Seven new Cancer Grand Challenges – with awards of up to £20m – available for research teams around the world to tackle the biggest questions in cancer research. Read more: cruk.ink/4ha3LgZ 1/2

Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it. Strong power move for Team Cancer.

Fantastic to see fellow @newnhamcollege.bsky.social alumna @carolcooper.bsky.social this evening at Hart’s bookshop - can highly recommend ‘The History of Medicine in Twelve Objects’ #Medicine #MedicalHistory #HartsBookshop

Fascinating paper on how different races/ethnicities respond differently to anticancer therapies - such an important thing to understand for personalised medicine #CancerResearch aacrjournals.org/cancerdiscov...

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

Abstract. Systematic multiomic analysis has revealed ancestry-dependent molecular alterations, but their impact on the efficacy of anticancer treatment is yet largely unknown. In this study, we analyz...

aacrjournals.org

Not the banner you want seeing over this article from … checks notes … 8 days ago

Post the amazing science things you have done with federal funding.

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

www.reuters.com/world/europe...

EU medicines agency quits X, moves to Bluesky

The European Medicines Agency (EMA) said on Monday it would no longer post on X and would use rival Bluesky instead, becoming the latest organisation to quit a social media platform that some have criticised for its content.

reuters.com

At #FOG2025 and interested in drug discovery? Shruti Shikhare will be talking about how we are using #KnowledgeGraphs and #MachineLearming to gain insights - 4.35pm at the Data-Driven Drug Discovery Stage