Jacek Radwan

@jacek-radwan.bsky.social

evolutionary biologist working on the intersection of immunogenics and sexual selection

Our paper is out! 📣 we find that molecular measures of genetic variation do not predict heritable genetic variation across species - important implications for the application of genomic data for conservation! www.pnas.org/doi/10.1073/...

Nucleotide diversity is a poor predictor of short-term adaptive potential | PNAS

The capacity to adapt is essential for a population to avoid extinction in a changing world and is recognized as a global conservation priority. Ad...

pnas.org

Fantastic paper. Esp challenging the typical binary process of genesis or transition. Just as the first cells as we know them were possibly survivors of multitudes of attempts that did not survive to evolve. The origin of cellular life was not simple; neither was evolution to multiple cell types.

Toni Gabaldón@tonigabaldon.bsky.social · 2mo ago

Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...

Balancing selection maintains some remarkable biological diversity, but detecting it from genomic data alone can be tricky. This may bias our view of its true prevalence. We investigated what makes balancing selection more or less detectable in genomic scans. + in thread & preprint!

Max Reuter@maxreuter.bsky.social · 7mo ago

A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon: “Characterising the detectable and invisible fractions of genomic loci under balancing selection” www.biorxiv.org/content/10.6...

Our paper is out! We show that a 'missing-self' regulator (CFH) isn't as constrained as we thought, instead shows strong diversifying selection, likely driven by pathogen exploitation (e.g. Borrelia). Highlights how competing selective pressures shape innate immunity academic.oup.com/mbe/advance-...

A key regulator of missing-self innate immunity is polymorphic and under diversifying selection

Abstract. Host-parasite co-evolution drives the diversification of host immune genes involved in the recognition of pathogen antigens and molecular pattern

academic.oup.com

1) New manuscript preprint up: we model adaptation to changing environments under mating systems ranging from random mating via mutual choice monogamy through to female choice polygyny. 🧪https://www.biorxiv.org/content/10.64898/2026.03.30.715329v1

biorxiv.org

Peer Review is broken because a generation of Editors were trained that peer review is sacrosanct. Thus we have Editors who are clerks, sending and re-sending manuscripts to reviewers until they are happy. That's not the job. Be an Editor, not a clerk. Use your skill and judgement. Make decisions.

Please share: We are hosting the 2026 DZG evolutionary biology graduate meeting at Uni Hamburg on March 25-27: "Interactions and Coevolution: from Molecules to Species". #PhD students, early postdocs and advanced Master students in evolutionary biology are welcome to register! t1p.de/dzg2026evolbio

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Agreed, but learned society journals should strive to become more open and inclusive! Is this OK for our journals to hide behind paywalls that preclude free access by researchers from low income countries? More here: trulyopenscience.blogspot.com/2025/09/why-... #SocietyJournals #SciPub

Why learned society journals stick to paywalls?

Just returned from an excellent conference of the European Society for Evolutionary Biology (ESEB) in Barcelona. There was a lot of excell...

trulyopenscience.blogspot.com

#eseb2025 talks were great so far. Subjective ranking of the most common quotes: - theory and modeling: "with this very simple approach" - genomics: "using methodology you all know" - plenaries: "Nature/Science" in the bottom right of a slide - posters: "una cerveza por favor"

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