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Jose A Escudero

@jaescudero.bsky.social

Scientist interested in #integrons, antimicrobial resistance and the molecular basis of adaptation. Working at at CNB-CSIC.

114 Posts1198 Follower486 Folgt
Beuzón & Ruiz-Albert Lab@type3lab.bsky.social · last mo.

Many thanks to the Molecular Microbiology group of the Spanish Society of Microbiology (SEM) for awarding us with one of the two Josep Casadesús Prizes for best paper! rdcu.be/egczU Congrats also to @jaescudero.bsky.social for his!

Pseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection

Nature Microbiology - Single-cell gene expression analysis reveals phenotypic heterogeneity to enable bacterial specialization over the course of plant colonization.

rdcu.be

Mizrahi Lab@mizrahilab.bsky.social · 3mo ago

"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...

Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology

Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.

nature.com

Sara Mitri@saramitri.bsky.social · 4mo ago

Check out Snorre's latest preprint: www.biorxiv.org/content/10.6... I love this story: our 4-species synthetic bacterial community coexists across many simple environments and conditions. We show why (spoiler in the title)

biorxiv.org

Snorre Sulheim@sulheim.bsky.social · 4mo ago

Happy to finally share these results: Cross-feeding enables robust coexistence between four bacterial species www.biorxiv.org/content/10.6... With @saramitri.bsky.social @lambdapp.bsky.social @dan1elmachado.bsky.social @lhtxra.bsky.social Eric Ulrich, Alisson Gillon & Sam Testa #microsky

Centro Nacional de Biotecnología (CNB)@cnb-csic.bsky.social · 4mo ago

En #AGolpeDeBit #RTVE, @sanmillan.bsky.social investigador del #CNB @csic.es habla de este estudio liderado junto a Alfonso Santos López @uam.es y en colaboración con Ayari Fuentes #UNAM_MX centrado en el plásmido pOXA-48 de gran interés clínico 📻 ¡No te lo pierdas! www.rtve.es/play/audios/...

Resistencia a antibióticos: hallada nueva clave en plásmidos

Ponemos el foco en un estudio que identifica un nuevo mecanismo por el que los plásmidos pueden acelerar la aparición de resistencia a los antibióticos

rtve.es

Nature@nature.com · 4mo ago

Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies. go.nature.com/4dqQnXI

‘Treasure trove’ of antiviral proteins could inspire powerful molecular tools

Two research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.

go.nature.com

Teresa M. Coque@tmcoque.bsky.social · 4mo ago

1. Despite limited Ab exposure, the Wayampi gut microbiome harbors a robust "background" resistome of ACQUIRED resistance genes (antibiotic, metal, biocide) shared with Westerns=AMR is an ancient and conserved feature rather than solely a by-product of human activities.

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Jose A Escudero@jaescudero.bsky.social · 5mo ago

I am not very active lately in social media, but if you want to see one of our latest works check Alberto’s post on the fitness cost of AMR genes. Great delivery from him and all collaborators. Thanks, guys! bsky.app/profile/albe...

Alberto HCA@albertohca.bsky.social · 5mo ago

Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼

Alberto HCA@albertohca.bsky.social · 5mo ago

Excited to share our latest work! 📝 We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬 Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them. Learn more 👇🏼

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 5mo ago

Fitness effects of antimicrobial resistance genes in changing environments https://www.biorxiv.org/content/10.64898/2026.03.06.710025v1

Pablo Laborda@pablolaborda.bsky.social · 9mo ago

New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 9mo ago

Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1

Zeynep Baharoglu@zeynepbaharoglu.bsky.social · 11mo ago

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

science.org

Melanie Blokesch@mblokesch.bsky.social · 11mo ago

Excited to share my latest review, now published in the Royal Society theme issue on ‘The ecology and evolution of bacterial immune systems' (available OA): Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae royalsocietypublishing.org/doi/10.1098/...

Defence systems encoded by core genomic islands of seventh pandemic Vibrio cholerae | Philosophical Transactions of the Royal Society B: Biological Sciences

Vibrio cholerae, the causative agent of cholera, has triggered seven pandemics, with the seventh pandemic emerging in 1961. The success of seventh pandemic El Tor (7PET) V. cholerae as a human pathogen is linked to its acquisition of mobile genetic ...

royalsocietypublishing.org

Zeynep Baharoglu@zeynepbaharoglu.bsky.social · last yr.

Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects? 🦠 =>processes evolutionarily tuned to be sensitive to translation speed eg: motility, iron homeostasis, leader peptide attenuation (ex: trp). #rnasky #microsky www.sciencedirect.com/science/arti...

Are Bacterial Processes Dependent on Global Ribosome Pausing Affected by tRNA Modification Defects?

By integrating a literature review with transcriptomic, proteomic, and phenotypic data from two model bacteria, Escherichia coli and Vibrio cholerae, …

sciencedirect.com

Jerónimo Rodríguez-Beltrán@jerorb.bsky.social · last yr.

🚨🚨 New paper in @narjournal.bsky.social! 🍾 Excludons are pairs of overlapping genes that block each other’s expression (basically, reverse operons). We built a tool to identify them in bacterial genomes using transcriptomic data, in an awesome collab led by Iñigo Lasa and Álvaro San Martín. 👇

ExcludonFinder: mapping transcriptional overlaps between neighboring genes

Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc

academic.oup.com