Alexander Jais
@jaislab.bsky.social
Group leader @HIMAG_Leipzig | Neurobiology & Metabolic Research | Neural circuits linking food intake, brain function and metabolism in obesity
🧠Meet Dr Alexander Jais ( @www.helmholtz-munich.de ), #EFSD/@novonordiskfond Future Leaders Awardee. Don't miss his presentation on sucrose-responsive neurons & glucose metabolism at the EFSD/NNF Future Leaders Symposium at #EASD2025: 📅Thurs, 18 Sept 2025 | 🕛12:45 CEST 📖 doi.org/10.1016/j.is...
Brain lithium levels drop early in AD before symptoms fully emerge
Lithium deficiency and the onset of Alzheimer’s disease
Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...
rdcu.be
Congratulations 🎉 New iScience paper by PhD student Stephanie Puente‑Ruiz: The non-classical opioid peptide N/OFQ promotes macrophage recruitment and metabolic inflammation www.cell.com/iscience/ful...
B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity
Biological sciences; Endocrinology; Natural sciences; Physiology
cell.com
The biology of eating disorders www.nature.com/articles/s41...
Examining the biological causes of eating disorders to inform treatment strategies - Nature Reviews Neuroscience
Recent years have seen a growth in our understanding of the biological drivers of eating disorders and their interactions with environmental and psychosocial factors. Foldi and Griffiths consider how ...
nature.com
This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...
A simple action reduces high-fat diet intake and obesity in mice
Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…
sciencedirect.com
Based on studies in mice selective, durable AgRP neuron inhibition may prove an attractive strategy for the future treatment of T2D in humans www.jci.org/articles/vie...
Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.
Tierversuche: Warum sich mehr als 110 Forschende zu den Experimenten bekennen
Aus Deutschland sprechen sich 110 Wissenschaftlerinnen und Wissenschaftler öffentlich für Tierversuche aus. Frank Kirchhoff, Initiator der Aktion, sagt, warum Experimente an Mäusen, Ratten und Fischen immer noch sein müssen.
spiegel.de
Check out the roadmap to the first consensus atlas of human and mouse #adiposetissue. Great initiative by the adipose bionetwork of #humancellatlas! @humancellatlas.org @humancellatlas.bsky.social
Nature Metabolism@natmetabolism.nature.com · last yr.
Is increased hunger really a primary driver of obesity? In this Letter to the Editor in @nejm.org, Thorkild Sørensen, Mark Friedman and I question the widespread idea that many develop obesity because they overeat 👇 1/5 www.nejm.org/doi/full/10.... @cbmr.science
The Physiology of Hunger | NEJM
To the Editor: The review article by Fasano (Jan. 23 issue)1 concerning human nutrition and hunger regulation omits the crucial role of autophagy, a cellular recycling process vital for maintaining...
nejm.org
GABAergic, Non-AgRP neurons are critical for the regulation of overnutrition 🍟🍔 - this new study shows that leptin exerts a substantial portion of its appetite- and body-weight-regulatory effects via PNOC/NPY-expressing neurons! @cp-cell.bsky.social @mpi-metabolism.bsky.social
Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis
Activation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC neurons in the murine ARC as mediators of leptin action in body weight maintenance. Moreover, they molecularly and fu...
cell.com
A critical role of Notch signalling in brain endothelial cells in the pleiotropic effects of short-term dietary transitions on blood brain barrier functionality @cp-cellreports.bsky.social www.cell.com/cell-reports...
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Zhu et al. describe a rapid downregulation of Notch1 expression in hypothalamic blood-brain barrier (BBB) endothelial cells after high-fat diet (HFD) feeding. Notch activation prevents HFD-induced red...
cell.com
Trem2 is more flexible than we thought, and likes to bind to ApoE4! Congrats #EmmaLietzke and #KaylaSprenger on your work! It's a privilege to work with you!! @cuendocrinology.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology
BACKGROUND The strongest genetic drivers of late-onset Alzheimer's disease (AD) are apolipoprotein E4 (ApoE4) and TREM2R47H. Despite their critical roles, the mechanisms underlying their interaction.....
alz-journals.onlinelibrary.wiley.com
A thread 🧵: Our study redefines current concepts of insulin entry into the brain under conditions of nutritional excess. www.sciencedirect.com/science/arti... @www.helmholtz-munich.de @mpi-metabolism.bsky.social
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…
sciencedirect.com
Our latest study @science.org #Immunology on perception of #hunger and #immunity. #BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones. @ukri.org @fbmh-uom.bsky.social www.science.org/doi/10.1126/...
Brain sensing of metabolic state regulates circulating monocytes
Brain-initiated hunger signals control circulating monocyte dynamics.
science.org
Congratulations, Yiyi! 🎉 We find that high-fat diet rapidly reduces Notch signaling in the brain, affecting glucose uptake and insulin sensitivity. Our study also highlights the role of caveolae in blood-brain barrier permeability and insulin transport: www.sciencedirect.com/science/arti...
Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling
Short-term transition to high-fat diet (HFD) feeding causes rapid changes in the molecular architecture of the blood-brain barrier (BBB), BBB permeabi…
sciencedirect.com