Whole-body cellular activity imaging in zebrafish, headed by Virginie Ruetten @vmsruetten.bsky.social - new paper is out: www.nature.com/articles/s41...
Imaging cellular activity across all organs reveals body-wide circuits - Nature
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
nature.com
Excited to share our new Cell Reports paper on paratenial thalamus (PT), which identifies a molecular marker for PT, and shows how PT interacts with the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala, all done by my grad student Nigel Dao: www.sciencedirect.com/science/arti...
If you thought "everything is everywhere" in the brain: inactivations reveal a clear distinction of labor. Sensory areas sense, colliculus promotes eligible actions (!), and prefrontal cortex integrates. The role of superior colliculus in a logistic decision www.biorxiv.org/content/10.6...
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish! www.biorxiv.org/content/10.6...
Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex
Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...
biorxiv.org
Amygdala dopamine is often studied in response to external rewards or threats. But what happens during self-initiated exploration? Our new preprint suggests a broader role: a state-dependent salience signal linking exploration and associative learning. 👉 www.biorxiv.org/content/10.6...
Basolateral amygdala dopamine signals behavioural salience across exploration and learning
Animals must balance exploration with threat avoidance, yet how neuromodulatory signals shape information-seeking states remains unclear. Using fibre photometry recordings in the basolateral amygdala ...
biorxiv.org
Brainwide Representation of Navigation Enny recorded >20k neurons across forebrain and midbrain while mice navigated 1D VR. She found that every region encodes spatial position! Hippocampal formation stands out only in uniformity of the representation. But visual cortex beats it in precision...
Enny van Beest@ennyvb.bsky.social · 6d agoTextbook: tracking position during navigation is primarily the job of the hippocampus. Recent findings suggest a more complicated story. Recording >20k neurons brainwide, we indeed find spatial representations in every region! With @kenneth-harris.bsky.social and @carandinilab.net
Jobe Ritchie , a postdoc in the lab, decided he wanted to build a better platform for scoring behavior. www.biorxiv.org/content/10.6...
ABEL: an active-learning behavior estimation and labeling platform
Detailed behavior analysis is essential for thorough characterization of ethologically relevant behaviors in model organisms, yet manual annotation of the full behavioral repertoire remains subjective...
biorxiv.org
Textbook: tracking position during navigation is primarily the job of the hippocampus. Recent findings suggest a more complicated story. Recording >20k neurons brainwide, we indeed find spatial representations in every region! With @kenneth-harris.bsky.social and @carandinilab.net
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 6d agoBrainwide representation of navigation https://www.biorxiv.org/content/10.64898/2026.08.29.747979v1
How fast can mice learn complex mazes? With @mameister4.bsky.social we reveal memory, generalization, latent learning, and remote credit assignment of mice in the Manhattan Maze. Do mice born without a cortex or hippocampus have them too? Check it out! www.biorxiv.org/content/10.6...
Rapid spatial cognition in mice, with and without neocortex and hippocampus
Rapid learning, memory, and generalization are often attributed to circuits of the neocortex and hippocampus, but their specific role remains unclear. To examine these cognitive abilities together in ...
biorxiv.org
Wow! 🧠 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
Brainwide representation of navigation
Tracking your position in the environment during navigation requires integrating multiple signals into a spatial representation. This process is thought to occur primarily in the hippocampal formation...
biorxiv.org
Supper happy to see this published. In short, we show how dendrites and inhibition allow neural circuits to learn new representations while protecting representations that are already stored in the network. See below for a detailed post by @cmiehl.bsky.social: www.sciencedirect.com/science/arti...
sciencedirect.com
Distinct prefrontal-amygdala connectivity drives consolidated fear memories https://www.biorxiv.org/content/10.64898/2026.08.14.744891v1
What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...
Wake-activated neuronal populations that regulate sleep drive - Nature
Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red...
nature.com
Yale Neuroscience 🧠 @yaleneuro.bsky.social is hiring this year! We have 2 searches, one cell/molecular/systems neuro (apply.interfolio.com/190736) and one computational neuro (apply.interfolio.com/190740). Got questions about the searches, the department, or the process? Please ask, happy to chat!
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I am proud of this paper. Since it came out in 2022 it has received 0 citations (yes that's a zero). But multiple young scientists have found it useful! (from other labs, so they were not coerced...). Perhaps you will find it useful too? SOME TIPS FOR WRITING SCIENCE doi.org/10.1523/ENEU...
Some Tips for Writing Science
When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...
doi.org
A long-standing question in neuroscience is why the eCB system uses two ligands for the same receptors and how their release differs. To address it, we’re happy to share a pair of selective GRAB sensors that detect 2-AG and AEA, respectively, in real time. biorxiv.org/content/10.6...
Neuroscience hasn’t been able to investigate the role of astrocytes in memory because “all the tools we have to understand how the brain works are related to neurons." #neuroskyence By @davidbrz.bsky.social www.thetransmitter.org/memory/are-p...
Are parts of the memory trace found in the ‘astroengram?’
Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.
thetransmitter.org
Reshaping cortical circuits through stimulation is an emerging therapy for restoring cognitive function. Here find that stimulation strengthens cell assemblies, which is linked to cell-type-specific gene regulation @nature.com @konopkalab.bsky.social www.nature.com/articles/s41...
Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!
Nature Methods@natmethods.nature.com · last mo.An Analysis from @ptrrupprecht.bsky.social et al investigates the behavior of GCaMP8 variants in spike inference using different algorithms. www.nature.com/articles/s41...
The Cellular and Synaptic Actions of Dopamine During Behavior https://www.biorxiv.org/content/10.64898/2026.08.05.742858v1
For a neural circuit to be "specialized", does it need specialized neurons? In our new work - now out in @NatureNeuro - we address this question in the BLA, using representational geometry to propose a new population-centric way of defining circuit specialization. 🧵👇 1/
🎉 this paper is now out - we show how subicular plateaus are linked to reward locations. Congratulations to the whole team! www.cell.com/cell-reports...
Subicular plateaus signal reward locations during goal-directed behavior
Using in vivo whole-cell recordings during goal-directed navigation, Bhatia, Adel, and Grienberger identify plateaus as a prominent feature of subiculum activity. These events preferentially occur nea...
cell.com
Christine Grienberger@cgrienberger.bsky.social · 7mo ago🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...
Structural plasticity of the axon initial segment is important for the regulation of neuronal activity. Some recent thoughts on how AIS plasticity may shape learning and memory in neuronal circuits in health and disease: doi.org/10.1016/j.co...
Redirecting
doi.org
🧠New preprint! We identify minimal circuit motifs that generate diverse selectivity to support categorization, comparison, and decision-making. Trained RNNs converge on the same motifs, revealing principles that link connectivity to computation. @mpinb.mpg.de www.biorxiv.org/content/10.6...
Structured connectivity for structured sequential computations
Cortical computations emerge from the coordinated activity of recurrent neural circuits and are often described through population dynamics and neuronal selectivity. However, how the backbone of the c...
biorxiv.org
4/6 This is where we were surprised: we built Nyx for our lab, it generalised well beyond it. The same pipeline worked across mice 🐭, rats 🐀, humans 🧑, a jackdaw 🐦 and a tegu lizard 🦎. Across early development through ageing. Across different brain regions and intracranial recordings.
🌙 Our new preprint is out! We present Nyx, an open-source unsupervised framework for sleep scoring across species, lifespan and modalities. Validated on 19 datasets and 8,000 hours of sleep, from mice to humans, lizards and birds, across development, ageing, health and disease.
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last mo.Nyx: a flexible framework for sleep scoring across species, lifespan and modalities https://www.biorxiv.org/content/10.64898/2026.07.24.740558v1
The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...
Basolateral amygdala dopamine transmits emotional salience - Nature Communications
The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...
nature.com
light-activated tetanus neurotoxin (LATeNT) by the @aliceyting.bsky.social lab. Includes a comparison with the light-switchable PdCO (www.nature.com/articles/s41...), showing a long lasting inhibition for 1h hour post illumination. www.nature.com/articles/s41...
Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo - Nature Methods
LATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo...
nature.com
Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.07.29.741555v1
