Congratulations to @frengerquentin.bsky.social, one of our Biomed News curator. Quentin curates the weekly report on non-canonical #autophagy. You can subscribe to his report here biomed.news/bims-nocaut First person – Quentin Frenger journals.biologists.com/jcs/article/...

First person – Quentin Frenger

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Quentin Fren...

journals.biologists.com

Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...

Please check out our new preprint! We find an unexpected role for #CASM in regulating p62 mediated activation of the KEAP1/NRF2 pathway to initiate a cytoprotective antioxidant transcriptional response. More functions for #CASM in responding to lysosome stress. www.biorxiv.org/content/10.6... 1/2

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

biorxiv.org

Happy to share that our study is now published @jcellsci.bsky.social ! doi.org/10.1242/jcs....

Vimentin intermediate filaments support autophagosome biogenesis at ER–endosome contact sites in response to starvation

Highlighted Article: Vimentin intermediate filaments rapidly reorganize to mobilize ER–endosome contact sites, establishing a crucial spatial platform for starvation-induced autophagy initiation.

doi.org

Quentin Frenger@frengerquentin.bsky.social · 8mo ago

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. www.biorxiv.org/content/10.6... #CellBiology #Autophagy #Vimentin

together with an interview of @frengerquentin.bsky.social !! see there for details: journals.biologists.com/jcs/article/...

First person – Quentin Frenger

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Quentin Fren...

journals.biologists.com

Vimentin intermediate filaments support autophagosome biogenesis at ER–endosome contact sites in response to starvation journals.biologists.com/jcs/article-... check out our last @membramics-lab.bsky.social publication by @frengerquentin.bsky.social on the role of vimentin in autophagy

Peroxi_SPY probes were designed for peroxisome live cell imaging. Turns out they work with fixed cells as well! Peroxi_SPY can thus be combined with immunofluorescence labeling. A new article provides a detailed protocol: app.jove.com/t/69405/pero... Products link: spirochrome.com/products/?_c...

Happy new year from @membramics-lab.bsky.social members!

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

@natcellbio.nature.com - Finally out! Skin cells mechanically protect their genome from UV by positioning melanin above nucleus. Keratin filaments & microtubules drive the process. Led by Silvia Benito-Martinez & @laurasalavessa.bsky.social @membramics-lab.bsky.social www.nature.com/articles/s41...

Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection - Nature Cell Biology

Benito-Martínez, Salavessa and colleagues show that keratin intermediate filaments and microtubules control the three-dimensional perinuclear position of melanin-containing organelles, shielding the D...

nature.com

[PUBLICATION] The @membramics-lab.bsky.social team shows how keratin is involved in melanin genome photoprotection at the cell level. 👏🏼 Co-1st authors: Silvia Benito Martinez & @laurasalavessa.bsky.social 🔗 doi.org/10.1038/s415... 📰 Read more on INEM's LinkedIn, and website: tinyurl.com/yr9pntvb

This baby is finally out! Our study in @natcellbio.nature.com shows how keratinocytes use intermediate filaments and microtubules to control melanin positioning for optimal photoprotection. A real tour de force, together with Silvia Benito-Martínez and @delevoyecedric.bsky.social.

Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection - Nature Cell Biology

Benito-Martínez, Salavessa and colleagues show that keratin intermediate filaments and microtubules control the three-dimensional perinuclear position of melanin-containing organelles, shielding the D...

nature.com

Reversible One-way Lipid Transfer at ER-Autophagosome Membrane Contact Sites via Atg2 www.biorxiv.org/content/10.1...

Reversible One-way Lipid Transfer at ER-Autophagosome Membrane Contact Sites via Atg2

Bridge-like lipid transfer proteins (LTPs) contain a repeating β-groove domain and long hydrophobic grooves that act as bridges at membrane contact sites (MCSs) to efficiently transfer lipids. Atg2 is...

biorxiv.org

#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.

VAPB is a negative regulator of STING-mediated innate immune signaling | Science Advances www.science.org/doi/10.1126/...

VAPB is a negative regulator of STING-mediated innate immune signaling

VAPB is a critical regulating factor in cGAS-STING–mediated innate immune responses.

science.org

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation www.biorxiv.org/content/10.6...

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation

Macroautophagy (autophagy) is a fundamental catabolic process requiring the biogenesis of the autophagosome to support cell survival during stress. While the roles of F-actin and microtubule cytoskele...

biorxiv.org

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation https://www.biorxiv.org/content/10.64898/2025.12.02.691851v1

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. www.biorxiv.org/content/10.6... #CellBiology #Autophagy #Vimentin

onlinelibrary.wiley.com/doi/10.1111/... Check out our last review on endolysosomal plasticity in pigment organelles biology by @laurasalavessa.bsky.social @delevoyecedric.bsky.social in @biologyofthecell.bsky.social !

Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology

The morphodynamical plasticity of the endolysosomal system supports the formation and function of specialized intracellular compartments, as exemplified by the pigment organelles in skin cells. In ep....

onlinelibrary.wiley.com

What a truly beautiful time at the European Intermediate Filament Meeting 2025 in Lyon! I was so glad to meet such a welcoming community. I'm honored to have won the Best Oral Communication Prize for my recent postdoc project on Vimentin and Autophagy! Huge thanks to the organizers!

New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social

The EMBO Journal@embojournal.org · 11mo ago

Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage @mike-hanna.bsky.social et al, @pdc-lab.bsky.social www.embopress.org/doi/full/10....

Super happy to see CLEM-Reg out in @natmethods.nature.com! A short thread on the algorithm behind it and how to try it out for yourself🧵(1/9) www.nature.com/articles/s41...

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy - Nature Methods

CLEM-Reg automates the three-dimensional alignment of volume correlative light and electron microscopy datasets by leveraging probabilistic point cloud registration techniques for fast and accurate re...

nature.com

www.science.org/doi/10.1126/... Important study! Authors identify PDZD8 (renamed LYVAC) as an ER-anchored lipid transfer protein. In response to lysosomal osmotic stress, it provides lipids to support lysosome swelling. Unlike ATG2, LYVAC does not supply lipids to damaged lysosomes.

LYVAC/PDZD8 is a lysosomal vacuolator

Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

science.org

www.nature.com/articles/s41... EBV-expanded B cells home to the CNS where they attract T cells, mainly via CXCR3 expression, to trigger multiple sclerosis. Congrats to the authors !

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

nature.com

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

Lysosomal membrane homeostasis and its importance in physiology and disease

Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

bit.ly

Sad days. www.pnas.org/doi/full/10.... www.nature.com/articles/s41...

You know it's going to be good when it says 'ATG16L1-dependent'😜! Congrats on the great work @carlaalemany.bsky.social, @julianedagraca.bsky.social !!!

MOREL Lab / MEMBRAMICS research@membramics-lab.bsky.social · last yr.

(again!) new publication for @membramics-lab.bsky.social, by @carlaalemany.bsky.social & @julianedagraca.bsky.social in collaboration with N Naffakh & JB Brault, we show that Influenza virus triggers an ATG16L1/Rab11 PI4P response at ER membrane for viral export journals.plos.org/plosbiology/...

FINALLY OUT ! After a long journey (of PhD and publication process) my paper on the role of ER-endosomes contact sites in autophagosome formation is officially out 🥳🥳 www.cell.com/cell-reports...

ER-endosome contacts generate a local environment promoting phagophore formation

Da Graça et al. identify ER-endosome contact sites as critical hubs for autophagosome biogenesis, where starvation triggers sequential endosome tethering to ER exit sites. This spatiotemporal coordina...

cell.com

🎉 Congratulations to @julianedagraca.bsky.social, recipient of the 2025 Beth Levine #ThesisPrize! Her outstanding research @membramics-lab.bsky.social on the role of ER/Endosome contact sites in the regulation of #autophagy captures the award's spirit of excellence and innovation. 👏

dear all! The Membrane Band (www.membraneband.com) will give a concert for the 30th Anniversary of the "Cell biology & Cancer Research Unit" (aka UMR144 for close friends) ‪of Curie Institute on Monday 23th fo June! @institutcurie.bsky.social see you there?