Exciting PhD vacancy in my lab at Amsterdam UMC! 4-year, fully funded KWF project studying cell-cell communication in the myeloma bone marrow niche and drug resistance. Feel free to share! More info: werkenbij.amsterdamumc.org/en/vacatures... #PhD #Myeloma #KWF @amsterdamumc.bsky.social

Vacatures - PhD hematology/oncology: bone marrow microenvironment in multiple myeloma - Amsterdam UMC

Explore how the bone marrow microenvironment drives therapy resistance in multiple myeloma. Develop innovative 3D models and single‑cell analyses in a dynamic research team at Amsterdam UMC.

werkenbij.amsterdamumc.org

Attending the European Myeloma Network meeting in Prague with my group. Interesting meeting in a beautiful city! PhD student Maaike Janssens is doing a great job presenting her work on stromal cell-dependent drug resistance in myeloma. #myeloma #research #conference

📣 New preprint alert! Co-authored by @spalaciosm.bsky.social and @andreacaldarola.bsky.social : Quantitative imaging of calcium dynamics with a green fluorescent biosensor and fluorescence lifetime imaging www.biorxiv.org/content/10.6...

Sharing a new preprint from my lab. www.biorxiv.org/content/10.6... We show that AID not only induces mutations in DLBCL, but also reprograms transcriptional networks linked to proliferation and cell-of-origin.This suggests a broader role for AID in lymphoma beyond its classic mutator function.

Please share. 💔

#Medsky🧪 #immunosky A RCT provides direct human evidence that the placebo effect can shape humoral immunity, showing that reward-related brain activity correlates with vaccine-induced antibody production & opening new avenues for treating many medical conditions. Pdf www.nature.com/articles/s41...

Marc Veldhoen@marcveld.bsky.social · 7mo ago

Placebo effect influences vaccine responses Placebo effect can shape humoral immunity. www.nature.com/artic... 1/3

pubmed.ncbi.nlm.nih.gov/41362770/

Recombination between fragile regions associated with chromosomal rearrangements in glioblastoma can be mediated by RAGs - PubMed

The RAGs, comprising RAG1 and RAG2, catalyze V(D)J recombination by recognizing recombination-signal sequences (RSS). Glioblastoma, the aggressive brain cancer, has many oncogenic chromosomal alterations; however, the mechanism of their generation is largely unknown. Here, we report that RAGs are ex …

pubmed.ncbi.nlm.nih.gov

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells rupress.org/jem/article/... @jem.org

Happy to share a new online preprint on the immunomodulatory properties of levamisole, a steroid-sparing agent in children with relapsing idiopathic nephrotic syndrome. Joint work with Prof. Florquin & LEARNS clinical trial. tinyurl.com/nhd62mhw @amsterdamumc.bsky.social #research #kidney #B-cell

Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy

Levamisole (LMS) is a small imidazole derivative with immunomodulatory properties. Despite its longstanding clinical use in Idiopathic Nephrotic Syndrome (INS), the mechanisms underlying its immune-re...

tinyurl.com

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm! www.nature.com/articles/s41...

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology

Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

nature.com

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated! www.biorxiv.org/content/10.6...

Thrilled and grateful to share that our research team at Amsterdam UMC has been awarded a new research grant from the Dutch Cancer Foundation (KWF) to study the bone marrow niche in multiple myeloma. Extremely thankful to KWF for their continued trust and support of our work! #myeloma #research 🔬🩸

Save the date! On behalf of the Society, I’m delighted to announce that the next International Society for Evolution, Ecology and Cancer conference will be taking place in Hersonissos, Crete, on May 21-24, 2026. Abstract submissions will open soon. More details: www.evocancer.com

Laat de kracht van muziek werken in positieve zin. Een AI gegenereerd anti-AZC nummer is megapopulair. Een tegenbeweging probeert nu het nummer Vrijheid, gelijkheid, zusterschap van Sophie Straat hoger te krijgen in de streaminglijsten. Helpen jullie mee? open.spotify.com/track/4EIM7Q...

Vrijheid, Gelijkheid, Zusterschap

open.spotify.com

Foreign Scholars Skip US Conferences “I don’t agree with the politicization of scientific funding, the destruction of data collection and openness... and I feel like traveling to America at this point is a partial endorsement of what’s going on,” Liston said. www.insidehighered.com/news/faculty...

Cautious or Protesting, Foreign Scholars Skip U.S. Conferences

As President Donald Trump deploys National Guard troops to American cities and ICE arrests pick up, some international scholars are opting out of U.S. travel.

insidehighered.com

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

go.nature.com

Scientists themselves determine what is valued within science. Yet we act as if beholden to external managers, bean-counters who confuse the production of papers with scientific progress. We don't have to find better ways to navigate the prison of metrics-driven scientific assessment.

‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social #AML #STAT3 #CXCR4 #MLL-AF9 www.sciencedirect.com/science/arti...

"Surprisingly, individual cells—from splenic lymphocytes to pluripotent stem cells—transcribe only ∼0.02%–3.1% of the genome, versus >80% in bulk, revealing limited genome engagement and profound cell-type and cell-to-cell heterogeneity" www.cell.com/cell/abstrac...

Single-cell nascent transcription reveals sparse genome usage and plasticity

scFLUENT-seq is a single-cell method that sensitively captures nascent nuclear transcriptomes to reveal mRNA and ncRNA dynamics, heterogeneity across chromatin compartments, and transcriptional divers...

cell.com

Do you know how badly things have to be going in America for us to be owned this hard by the Dutch? The Dutch of all people

Dave Lee@davelee.me · 11mo ago

Dutch late night TV has its take

What makes genes burst

What makes genes burst

Genes burst. Instead of being monotonously transcribed by a steady stream of RNA polymerases, active genes undergo transient and random pulses of transcription that are referred to as gene bursting. This property is ubiquitous and evolutionarily conserved from bacteria to humans, and reflects the inherent stochastic nature of most biological processes. The frequency and duration of gene busting events varies greatly between genes and is now recognized to be controlled by an intricate interplay between transcription factors, chromatin features, and the transcription machinery. Recent findings also point to proximal regulation of bursting by epigenetic chromatin states, a novel role of non-histone modifications, and of distal control of bursting patterns by enhancers. Uncovering the regulatory mechanisms of gene bursting sheds light on how cells maintain a diverse range of gene-specific expression by modulating the different kinetic parameters of bursting.

dlvr.it

Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis

Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonu...

jbc.org

Excised DNA circles from V(D)J recombination promote relapsed leukaemia Cutting your own DNA has a risk of leukaemia. www.nature.com/artic... 1/7

Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Nature - Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis,...

nature.com

Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics. 🔗 doi.org/10.1093/molbev/msaf152 #evobio #molbio

Respiratory viral infections awaken metastatic breast cancer cells in lungs Note: This concerns many infections (inflammation, trauma), including respiratory viruses and is NOT specific for SARS-CoV-2 as some claim. www.nature.com/artic... 1/9

Respiratory viral infections awaken metastatic breast cancer cells in lungs

Nature - Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by...

nature.com

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications

Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

nature.com

Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!

Gabriel Victora@victora.bsky.social · last yr.

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

YouTube video by Amanpour and Company

youtu.be

Interesting study on how to sensitize myeloma cells to the BCL2 inhibitor venetoclax by interfering with signal transduction pathways. #myeloma #science 🩸🔬https://www.nature.com/articles/s41408-025-01215-x

Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention - Blood Cancer Journal

Blood Cancer Journal - Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention

nature.com