Thrilled to share a preprint from a collaborative project with M Stucki’s team. We uncover a 2-component mechanism in which chromatin adaptors provide molecular specificity while TOPBP1 condensates organize and sustain ATM signaling at sites of DNA damage doi.org/10.64898/2026.08.21.746129

Thrilled to share our new preprint showing that TopBP1 condensates orchestrate nuclear actin remodeling during replication stress, thereby linking stress signaling, nuclear envelope organization, and genome stability. Led brilliantly by our former PhD student Elia Moarbess ! lnkd.in/g4UFD_MM

Give the laurels to the one who earned them. A thread that aims to attribute credits to the originators of important ‘firsts’ This is on the making. Please contribute to accurate historical records with comments and reading recommendations 🧵👇

📢 International Symposium on Protein Interactions and Self-Assembly Join us in ☀️ Lisbon 🇵🇹 🗓️ 14–16 July 2025 🗣️ A great programme + short talks selected from abstracts. 🔗 Check it here: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html 🔬 Powered by #TWIN2PIPSA at @cienciasulisboa.bsky.social

Our latest work "TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer" led by Laura Morano, is now out in @eLife! Huge thanks to our collaborators at IGH and IRCM. And a special thought goes to Angelos Constantinou. 🙏 doi.org/10.7554/eLif...

Exciting PhD project available in our lab (time sensitive)! 👇

FANCX=FAAP100, new Fanconi Anemia gene Two new papers identify 3 families with FAAP100 homozygous mutations leading to severe developmental and hematologic abnormalities leading to death in utero or in early life. www.jci.org/articles/vie... www.jci.org/articles/vie...

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

Nuclear and genome dynamics underlying DNA double-strand break repair

Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

rdcu.be

Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk. www.keystonesymposia.org/conferences/...

Dear Colleagues, We are extending our early bird registration deadline to December 17th as there have been some issues both with the Carte Achat service as well as with the website. All have now been sorted.We look forward to seeing you for this special event that will honour the memory of Angelos.