Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

How do cancer-associated eccDNAs arise? Our work shows that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer. 1/2

Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications

Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

nature.com

We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!

Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668

The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

nature.com

‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)

A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

science.org

The world has lost its most powerful advocate for nature and hope. Yet many remain who will continue her legacy and I know she will continue to inspire generations more.

Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.

Professors x 10, Faculty of Medicine & Dentistry | Veredus

QUEEN MARY UNIVERSITY OF LONDON Professors x 10, Faculty of Medicine and Dentistry London Competitive Remuneration Package Queen Mary University of London seeks up to 10 world-leading translational re...

veredus.co.uk

Thrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

nature.com

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4

@efapostolou29.bsky.social @thecesarelab.bsky.social we're looking forward to your presentations at this fantastic meeting!

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Deadline approaching for #SGO25 🗓 31 Oct – 03 Nov 2025 📍Riviera Maya, Mexico Poster & Reg deadline: 01 Sept 2025 Details & Reg: bit.ly/45Mmhtv $250 registration grants available! Email amy@fusion-conferences.com with your name, position & current research topic.

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences: www.nature.com/naturecareer... www.nature.com/naturecareer...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515

Department of Biochemistry, School of Medicine—Basic Sciences

nature.com

Another exciting research article from a member of the #RepliFate network! The Altmeyer lab identified the CNOT1-CCR4-NOT complex as a multi-level suppressor of the 53BP1-p53-p21 signaling axis. Check out their findings here: doi.org/10.1016/j.ce...

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates

Our new non-denaturing nanoscale 3D DNA tracing technology provides single-cell (and sister-chromatid specific!) readout of chromatin structure with 10kb genomic resolution - Check it out! www.nature.com/articles/s41... Congratulations to Kai and Oyvind!!

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications

A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

nature.com

📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

New @nature.com An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer www.nature.com/articles/s41...

🔬Under the microscope: DNA damage tracked through cell generations🔬 It was a pleasure to write this #NewsAndViews with our PhD student Emma Reilly, online today @nature.com rdcu.be/em0qi @cruk-ci.bsky.social @spjacksongroup.bsky.social @yalepathology.bsky.social @yalecancer.bsky.social

Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...

Looking very much forward to the 2nd edition of the Fusion Conference on Spatial Genome Organisation #SGO25 @fusionconf.bsky.social @karimmekhail.bsky.social @chiololab.bsky.social. Early bird registration closes soon: June 2nd, 2025. Slots available for selected talks from abstracts: bit.ly/4492G6i

2nd Spatial Genome Organisation Conference | Fusion Conferences

Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...

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