Amazing structures, and distinct binding modes, of TOPBP1 or ETAA1 activating the ATR-ATRIP kinase by an allosteric mechanism. In NSMB from Pavletich lab: www.nature.com/articles/s41...

Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase - Nature Structural & Molecular Biology

Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TO...

nature.com

Happy to share ProTiler-Mut, a computational framework that leverages CRISPR tiling screens to map protein mutation–phenotype relationships, developed by Wei He and @hanxu-mdacc.bsky.social in collaboration with @raphguerois.bsky.social and our group. authors.elsevier.com/c/1nKys_siQz...

A ubiquitin chain-feeding mechanism for BRCA1-A https://www.biorxiv.org/content/10.64898/2026.06.05.730370v1

Fantastic meeting coming up July31-Aug2 in LA for those researchers and clinicians working on the genetic disorder Bloom Syndrome, associated with loss of DNA repair. Submit your poster abstracts by June 19 event.fourwaves.com/bloom-rx2026... www.bloomsyndromeassociation.org

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

Here is a link to my student Mitch's final published paper on the activity of Rad51 and Rad54 during the homology search. genesdev.cshlp.org/content/40/1...

🚨 We’re hiring! We’re looking for a Research Assistant / Junior Postdoc to join the Christie Lab at @petermaccc.bsky.social Ideally the candidate will have experience in analysis of single cell/nuclei RNA sequencing, and be capable of developing bioinformatics workflows and statistical analysis.

The human genome's most variable and clinically important regions (centromeres, telomeres, and acrocentric short arms) have been hardest to study at scale. Thrilled to share KaryoScope, our new preprint that brings them within reach. 🧵 www.biorxiv.org/content/10.6...

Every discovery begins with a bright spark✨ Donate now to support the next generation of scientists at SVI and help make future discoveries possible: www.svi.edu.au/support-us/d...

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

annualreviews.org

This is going to be an awesome day, covering clinical translation of cell and gene therapies in Australia, held at the brand new ACMD building in Melbourne. Previous meetings have been excellent, and oversubscribed - make sure to register ASAP www.eventbrite.com.au/e/advances-i...

🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!! register here: us06web.zoom.us/webinar/regi...

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

We show that the E3 ubiquitin ligase DTX2 creates a dual hybrid ADP-ribosyl-ubiquitin mark (ADPr-Ub) at DNA damage sites, driving the recruitment of RNF114, RNF138, and RNF166 proteins independently of HPF1. journals.plos.org/plosbiology/...

Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!

Most genetic interaction studies measure gene relationships in one condition, but environment can reshape which genes depend on each other. Today in Molecular Cell, Luke Gilbert & team deliver the first systematic, multi-condition map of genetic rewiring in human cells.

Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...

Today, we’re launching a new company, ALTx Therapeutics. Founded by Simon Boulton, the company will develop the first precision therapies targeting ALT cancers, in partnership with Slingshot Therapeutics Limited and @crhorizons.bsky.social. Find out more ➡️ www.crick.ac.uk/news/2026-02...

A 1-day Melbourne workshop on Gene Editing in Blood and Immune Cells. February 20, register at editblood.com

2/Led by @hildapickett.bsky.social, with co-investigators @genomestability.bsky.social, @lisannes.bsky.social, Jacob Lewis, @yuhenglau.bsky.social, Sarah Henrikus, & the Cesare Lab, this project brings together expertise in telomere biology, DNA repair, biochemistry, drug discovery, & cell biology.

1/Delighted to be part of a team from @cmri.bsky.social, @sydney.edu.au, the University of Wollongong, and SVI (Melbourne) awarded a $5M NHMRC Synergy Grant to explore: “A mechanistic approach to developing precision therapies for ALT-dependent cancers.” www.nhmrc.gov.au/funding/find...

Just updated my X/Twitter profile. I suggest you try to encourage any colleagues remaining on that pit to do the same. Such a shame, as it was such an important place of science until not that long ago. :-(

8–11 June 2026 | 📍 Heraklion, Crete 🇬🇷 Get ready for Machines on Genes 2026, the 94th Harden Conference by the @biochemsoc.bsky.social — four days of molecular mechanisms and friendly discussions! 🧬☀️🔬❄️ Organised by @lapassmore.bsky.social, Dana Branzei, me.

New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase". Happy our lab could play a small part. Congrats Tracy, Ash Harman, Noa Lamm and the whole team. www.nature.com/articles/s41...

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications

Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...

nature.com

No, not that FANCL! New paper on FancL mutant mouse just out in @bloodadvances.bsky.social shows essential function of E3 RING ligase activity to phenotypes of #FanconiAnemia plus, Black Friday deal: a new model for testing gene editing therapies: ashpublications.org/bloodadvance...

Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯 @yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Susi Bantele@sbantele.bsky.social · 9mo ago

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Registration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com

🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing! docs.google.com/spreadsheets...

DNA REPAIR/GENOME STABILITY CONFERENCES

docs.google.com

🧵 Our latest preprint is available. It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism. Read more here 👉 www.medrxiv.org/content/10.1...

Multi-lineage natural gene therapy mediated by embryonic triploid mosaicism in the context of Fanconi anaemia

Fanconi anemia is a rare inherited bone marrow failure syndrome caused by inactivation of genes in the Fanconi anemia/BRCA DNA repair pathway. We report a patient with X-linked Fanconi anemia, and aty...

medrxiv.org