Phosphorylation and scaffolding by DGKζ mediate immune responses and antibody production in mouse B cells www.science.org/doi/10.1126/...

DGKζ es clave en la activación de los linfocitos B durante la respuesta inmune En su ausencia, se generan un 50% menos de células productoras de anticuerpos y de memoria ℹ️ https://f.mtr.cool/tzhrrutpee  @science.org SciSignaling: https://f.mtr.cool/dhhlhspmeh @cbm-csic-uam.bsky.social  @csic.es

Microbes that chew allergens mitigate anaphylaxis Preview of work demonstrating that oral & small intestinal bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. www.cell.com/cell-host-mi...

Microbes that chew allergens mitigate anaphylaxis

In the current issue of Cell Host & Microbe, Sánchez-Martínez et al. demonstrate that oral and small-intestine bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. This study provides insights into microbial mechanisms underlying food-induced anaphylaxis and may point to new directions for advancing food allergy therapy.

cell.com

Microbes impact peanut allergy Mouth & gut contain peanut-degrading bacteria(Rothia) that metabolize PN allergens. Mice colonized w/Rothia show decreased anaphylaxis & allergic patients w/better PN tolerance have higher abundance of these bacteria www.cell.com/cell-host-mi...

Our April issue is now live! On the cover: Peanut allergy & microbes Bacteria in the oral cavity & small intestine can degrade immunodominant peanut allergens, limiting anaphylaxis www.cell.com/cell-host-mi...

New online! Bacterial allies against food anaphylaxis

Bacterial allies against food anaphylaxis

Nature Reviews Microbiology, Published online: 20 March 2026; doi:10.1038/s41579-026-01300-3This study shows that some human microbiota bacteria can metabolize immunodominant peanut allergens, thus modulating IgE-mediated anaphylaxis.

dlvr.it

Un recuerdo hoy (y todos los días) para todas las mujeres investigadoras, en el #DiaInternacionalDeLaMujer #8M seguimos implicados todos/as para conseguir la tan deseada igualdad entre hombres y mujeres lo antes posible. Ya vamos tarde. 💜 @cnb-csic.bsky.social @sebbm.bsky.social @csic.es @uam.es

a woman looks through a microscope in a lab

ALT: a woman looks through a microscope in a lab

media.tenor.com

#Peanut-processing #microbes ward off dangerous #allergic #shock www.nature.com/articles/d41...

Peanut-processing microbes ward off dangerous allergic shock

Scientists identify bacteria that digest allergy-triggering compounds in peanuts, which can be life-threatening to those with allergies.

nature.com

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members @cp-cellreports.bsky.social www.cell.com/cell-reports...

IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and inhibitory CD300 family members

Izawa et al. identify sphingomyelin and ceramide species as ligands for CD300d3 and CD300f. CD300d3 enhances IgE-mediated murine mast cell activation via its ligands, whereas CD300f inhibits it. Mast ...

cell.com

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Your microbiome may determine your risk of a severe allergic reaction

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

newscientist.com

Microbiota impact peanut allergy Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria www.cell.com/cell-host-mi...

Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis

Sánchez-Martínez and Rondeau et al. reveal that human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis. This study...

cell.com

Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation. www.biorxiv.org/content/10.6...

Mast cell desensitization induces a distinct IgE-dependent transcriptional program associated with immune regulation https://www.biorxiv.org/content/10.64898/2026.02.28.708745v1

Muy agradecidos a El Mundo por divulgar nuestro trabajo en @cp-cellhostmicrobe.bsky.social donde demostramos que #bacterias orales degradan #alérgenos alimentarios, modulando respuestas #IgE y #anafilaxia. www.elmundo.es/ciencia-y-sa...

Una bacteria de la saliva 'protege' de la alergia al cacahuete, destruyendo en la boca las proteínas dañinas

Dos personas alérgicas a un mismo alimento pueden tener reacciones de diferente intensidad. Lo que una tolera sin problemas, en otra desencadena una fuerte respuesta. Entre las...

elmundo.es

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa y la Universidad de Canadá: okdiario.com/salud/saliva...

Alergia al cacahuete: la ciencia mira a la boca para frenar la enfermedad

La saliva, clave contra la alergia al cacahuete, según el hospital La Princesa de la Comunidad de Madrid y la Universidad de Canadá

okdiario.com

Human oral microbes degrade peanut allergens, thereby reducing IgE recognition, systemic availability, mast cell activation, and anaphylaxis @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...

Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete: www.agenciasinc.es/Noticias/Las...

Las bacterias de la saliva pueden ayudar a reducir las reacciones alérgicas al cacahuete

Un equipo científico de España y Canadá ha demostrado que ciertos microorganismos presentes en la boca influyen en la respuesta del sistema inmunitario frente a este alimento. Los resultados revelan nuevas vías de prevención centradas en el equilibrio de la microbiota.

agenciasinc.es

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

Your microbiome may determine your risk of a severe allergic reaction

The microbes that live in our mouth and gut may influence whether an allergic reaction to peanuts is mild or life-threatening, and could be harnessed to ward off a severe attack

newscientist.com

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes @cp-immunity.bsky.social www.cell.com/immunity/ful... @rockefeller.edu

🧵 1/6 Vaccinating allergic patients carries risks: the patient’s IgE recognizes allergen extracts and can trigger severe adverse reactions. To address this, Dr. Roy Patterson (1970s) proposed an innovative approach: modifying the extracts by polymerizing them with glutaraldehyde.

Today at #PreprintHub2, Elisa Sánchez from Universidad Autónoma de Madrid will present the preprint by @alexaweingarden.bsky.social, “Gut microbial composition modulates food-specific CD4+ T cells in food allergy” from the Marc K. Jenkins lab 🥜🤒❌ www.biorxiv.org/content/10.1...

@biorxivpreprint.bsky.social A single-cell atlas of intestinal immune cells across the day-night cycle reveals dynamic populations www.biorxiv.org/content/10.6... @jkpfeiff.bsky.social @utswim.bsky.social @lhooperlab.bsky.social

Review @natrevimmunol.nature.com How crosstalk at the immune synapse shapes T cell and dendritic cell biologys www.nature.com/articles/s41...

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

Growth control as a central regulator for tuning the cellular context

The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...

biorxiv.org

Grateful for the invitation to present at the 3rd Research Day of the METRI²A Group at @idibaps.bsky.social. A pleasure to discuss how #microbial metabolism of allergens impacts #allergicinflammation and #anaphylaxis.

Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS

Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy

Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.

scim.ag

We enjoyed discussing in @allergy-eaaci.bsky.social the findings by Cembellin-Prieto et al. (@johnshopkinsmmi.bsky.social) published in @natimmunol.nature.com, who identified a regulatory #mechanism mediated by #Bcell-derived #acetylcholine during #influenza #infection. doi.org/10.1111/all....

“The bad review will come from your list of suggested reviewers”

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social www.science.org/doi/10.1126/...