Una escena de la novel·la "El mal entès", de @mariusserra.bsky.social, ha disparat el meu ofici de genetista de poblacions. La segona mala notícia que rep el protagonista només pot passar amb una probabilitat del 3%. Ja és mala sort!
Juan Antonio Rodríguez
@jrotwitguez.bsky.social
MSCA Researcher @ Globe Institute (Copenhagen) A cocktail of 3D genomes 🧬, GWAS, evolution and sprinkles of randomness. Metagenomics and microbial things, lately. 🦠 Reposts with pH under 7, sometimes. 📍 Cedeira sempre, now in 🇩🇰
Dale RT a este Cubarsí de la SUERTE para que España gane la final
Do social bird species have more stable demographic histories? We do not find this to be the case in our new preprint doi.org/10.32942/X2N... Together with @ryangermain.bsky.social and many others
#SMBE2026! Join us in Open Session 6, where I'll be giving a flash talk on the work @henriklicht.bsky.social and I have been doing on root-symbiotic entomopathogenic fungi, ie fungi that cause disease in insects and form symbioses with plants! 🦗🌾 It starts in the main hall in 10 mins!
Can you believe that until now there were more genomes sequenced for the woolly mammoth than for living African elephants? Today, we bring you the first genomic, continent-scale analyses of 232 high-quality genomes of both species, the savanna and forest elephant. www.nature.com/articles/s41...
Tempted to add Metal gifs; that's how cool METALoci sounds! In their recent article @natsmb.nature.com, @dariloops.bsky.social @mamartirenom.bsky.social @jrotwitguez.bsky.social @imotagom.bsky.social and colleagues shed light on sex-determining 3D regulatory hubs. www.nature.com/articles/s41...
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology
METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...
nature.com
The final chapter of my PhD thesis, is finally published in GBE! academic.oup.com/gbe/article/... You can also read the earlier recommendation by PCI in a nice little summary here: evolbiol.peercommunityin.org/articles/rec... #palaeoproteomics #phylogenetics
Assessing the potential of ancient protein sequences in the study of hominid evolution
Abstract. Palaeoproteomic data can provide invaluable insights into hominid evolution over long timescales. Yet, the potential and limitations of ancient p
academic.oup.com
This conservation genomics course looks great!!
Physalia-courses@ONLINE@physaliacourses.bsky.social · 5mo ago🚨 Advanced #ConservationGenomics | Online, 28 Sept–1 Oct with Giulia Fabbri & @rsbiello.bsky.social Learn to translate genomic data into real-world conservation strategies: interpret Ne & genetic load, design SNP panels, and inform monitoring & policy. www.physalia-courses.org/courses-work...
Once again: Why are we letting our world be shaped by such shallow people with no sense of history, culture, creativity or sometimes even logical reasoning?
404 Media@404media.co · 5mo agoQuote from Advait Paliwal, Brown dropout and co-creator of Einstein: “I think about horses. They used to pull carriages, but when cars came around, I'd argue horses became a lot more free... It would be weird if horses revolted and said ‘no, I want to pull carriages, this is my purpose in life.’”
🔊💥 How is sex determined? How is it encoded in the #3Dgenome? Read all about it in our last paper! www.nature.com/articles/s41... It’s been looong but feels satisfying to see this finally out. (With CapelLab, @dariloops.bsky.social Lab and @mamartirenom.bsky.social Lab) 🧵👇
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology
METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...
nature.com
If you are a scientist, working on biology, wondering where to submit your manuscript given the current issues with the academic publishing system, check out wheretopublish.github.io! We did this thinking change is possible. Let’s make it happen!
Where to Publish?
wheretopublish.github.io
Nicolas Clairis@nclairis.bsky.social · 6mo agoDear all, I'm happy to present you a side project done with @diegoharta.bsky.social @phylogenetrips.bsky.social & Lucas Baudouin regarding the publication landscape in Biology: wheretopublish.github.io 1/4
the cutoff scores for #MSCA postdoc fellowships are very high this year. has the score distribution shifted compared to previous years? I made a plot with scores from past years. if scores are at ceiling level, the process becomes essentially a lottery, because minor issues can lead to deductions.
Rereading these two papers: Holes in the hologenome: why host-microbe symbioses are not holobionts. journals.asm.org/doi/10.1128/... The Hologenome Concept: Helpful or Hollow? journals.plos.org/plosbiology/... And I still find myself in general agreement with most of the points in them
Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts | mBio
ABSTRACT The advent of relatively inexpensive tools for characterizing microbial communities has led to an explosion of research exploring the diversity, ecology, and evolution of microbe-host systems...
journals.asm.org
For example, a genomic sequence might only exert its influence if it is in a context where that part of the chromatin is open and accessible. There are history-dependent effects. /29
1/7 🧬 New preprint! What is it like to have one of the highest genomic diversities among metazoans? 🔗 www.biorxiv.org/content/10.6...
The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia
Amphioxus are small marine chordates that have broad ecological ranges, yet as adults form local settlements and exhibit limited mobility. Genomic surveys of two amphioxus species have suggested that they rank among the most genetically diverse metazoans. Here, we present the first accurate assessment of genomic diversity in the European amphioxus ( Branchiostoma lanceolatum ) and investigate the processes underlying this diversity. We leverage high-coverage whole-genome sequencing data from multiple individuals sampled at two geographically distant Atlantic and Mediterranean locations. Consistent with previous estimates in other amphioxus species, we measure exceptionally high genomic diversity, with an average heterozygosity of 2.73% in B. lanceolatum . Despite the large geographic separation between sampling sites, population differentiation is minimal, indicating extensive gene flow among distant adult settlements. Phylogenetic analyses combined with population genetic simulations confirm that this elevated genomic diversity is primarily driven by a large effective population size. Although adult amphioxus have limited mobility, our results indicate that long-distance larval dispersal mediated by ocean currents is sufficient to generate a near-panmictic population structure across their broad ecological range. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 207853 Agence Nationale de la Recherche, ANR-21-CE13-0034
biorxiv.org
🦙🧬Pleased to present our new paper out in @natcomms.nature.com 🧬🦙 Palaeogenomics of early camelid use in the Atacama Desert (Chile). We used ancient DNA to revisit animals being hunted/herded >3,000 years ago. Manuscript here: rdcu.be/eVwwl #aDNA #popgen Thread below🧵 Reposts appreciated :)
It all boils down to this! If we believe in science and the peer-review process in its broader sense, why wouldn’t we always choose to send our work to respectable non-profit journals from scientific societies that do a great job in the review process?
Mark A. Hanson@hansonmark.bsky.social · 8mo agoIn general, let's just stop paying companies that host this BS. Fight the drain of scientific publishing. arxiv.org/abs/2511.04820
It was an amazing day-in-3D! Happy to have shar3D some insights on how to look at the genome from a different perspective 🧶🧬 (Thanks #MSCA @ec.europa.eu for funding through #POPARCH)
Center for Evolutionary Hologenomics@hologenomics.bsky.social · 9mo ago🧬3D genome workshop 🧬 🤩 Yesterday @jrotwitguez.bsky.social tought an awesome full day workshop on #3D #genomics to a full classroom @ucph.bsky.social @dg.dk
The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity academic.oup.com/gbe/article/... 🧬🖥️🧪
O vodka Pascual Veiga é o bum cerebral co que hoxe non contabas.
👏 It really shows how powerful meetings can be for sparking ideas and collaborations —and when those turn into joint efforts like this, even greater! Thank you all for this fun adventure! @mbrasovives.bsky.social @diegoharta.bsky.social @jrotwitguez.bsky.social @theafrogers.bsky.social et al
Juan Antonio Rodríguez@jrotwitguez.bsky.social · 9mo agoSo, it all started after we organised a symposium at the @official-smbe.bsky.social meeting in 2024, in Puerto Vallarta, Mexico 🇲🇽. Together with all the speakers (all in the picture), we joined forces to write this Perspective for GBE, summarising the key ideas and results presented there. (3/n)
Read the whole paper and more information about my research and ongoing projects at: emiliomarmol.academicwebsite.com www.cell.com/cell/fulltex...
Emilio Marmol Sanchez | Ancient RNA
Researcher exploring ancient RNA, epigenetics and 3D genomics in extinct and extant species. View my CV, highlights, and contact information.
emiliomarmol.academicwebsite.com
🦣🧬🦣🤯💥We are pleased to share our new paper about ancient RNA expression profiles from the Woolly Mammoth, now published in Cell @cellpress.bsky.social www.cell.com/cell/fulltex... If you want to know more, read the 🧵 below:
🔊New perspective piece out @genomebiolevol.bsky.social. "The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity" 💡🌀🌈 doi.org/10.1093/gbe/... Co-led with @mbrasovives.bsky.social and @diegoharta.bsky.social Check out our thread! 🧵👇 (1/n)
Validate User
doi.org
We have 🐟 herring pre print! Our new study reveals that ancient gene flow between Pacific and Atlantic herring played a key role in helping Atlantic herring adapt to the brackish waters of the Baltic Sea. www.biorxiv.org/content/10.1...
biorxiv.org
Really grateful to see our work featured by @quantamagazine.bsky.social in this piece on the evolution of genome regulation. Huge thanks to @philipcball.bsky.social for such a beautifully written article.
Philip Ball@philipcball.bsky.social · 10mo agoI adored writing this piece. It brings together several of the things preoccupying me right now, like chromatin organization and gene regulation. There's so much more to be said on that. Also, these marine critters look gorgeous. www.quantamagazine.org/loops-of-dna...
Are you interested in microRNAs 🧬 and goats 🐐? We are!! Then have a look at our preprint on how microRNA mutations segregate worldwide 🌍 in goat populations and the potentially derived consequences of prolonged inbreeding and geographical isolation. www.biorxiv.org/content/10.1...
The variability of goat microRNA genes is strongly shaped by functional constraints
Background MicroRNAs (miRNAs) are a type of small non-coding RNAs involved in the post-transcriptional repression of target mRNA transcripts, and responsible for the fine-tuning of numerous molecular ...
biorxiv.org
You can keep on gatekeeping us small fish, but know that we do good science and we will fight to keep publishing our good science. But also note that your gatekeeping has now cost Anais her whole career. If you're an Editor that did this - you kinda did that dude/dudette.