Researchers led by Ludwig @harvard.edu’s @judithagudo.bsky.social Monica Cassandras & Xavier Sanchez have identified in preclinical studies a mechanism metastasizing triple-negative breast cancer cells engage to thwart immune attack & a drug that could disrupt it to curtail metastasis bit.ly/4r7kJBp

www.nature.com/articles/s41... The seeds of metastasis harness stress hormones to escape immune surveillance. So proud of this work! @harvardmed.bsky.social @danafarbernews.bsky.social @dfcibreastonc.bsky.social

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding - Nature

Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

nature.com

New research published by @danafarber.bsky.social’s Judith Agudo, PhD, and colleagues in @nature.com today reveals a new strategy to prevent the metastasis of triple-negative breast cancer. ➡️ bit.ly/4rLuOFj

Why does cancer come back after years of remission? @nature.com shares how researchers are uncovering what causes dormant tumor cells to reawaken. @judithagudo.bsky.social offered insights into why tumor cells may enter dormancy as a protective mechanism. Read more: bit.ly/4btv5Y6

Why cancer can come back years later — and how to stop it

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

bit.ly

Our researchers are using novel spatial tools to learn how immune cells affect cancer. “I don’t think we appreciated how much the spatial dynamics of the immune system matter,” says @judithagudo.bsky.social. Learn more about what researchers are learning from this technology: bit.ly/49uOtSg

Seeing Is Believing | Dana-Farber Cancer Institute

Technicolor images of tumor samples are changing cancer research.

bit.ly

Honored to contribute on this piece explaining why cancer comes back (sometimes years later) with leaders in the field!🤩

Dana-Farber Cancer Institute@danafarber.bsky.social · 9mo ago

Why does cancer come back after years of remission? @nature.com shares how researchers are uncovering what causes dormant tumor cells to reawaken. @judithagudo.bsky.social offered insights into why tumor cells may enter dormancy as a protective mechanism. Read more: bit.ly/4btv5Y6

Why cancer can come back years later — and how to stop it www.nature.com/articles/d41...

Important to see the acknowledgement of cancer dormancy & that top journals continue to highlight & publish on this topic. This problem is now studied in major Institutions worldwide. Congrats to all who work in this space! It is making & will make a difference! www.nature.com/articles/d41...

Why cancer can come back years later — and how to stop it

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

nature.com

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment go.nature.com/3NgcKDT

Why cancer can come back years later — and how to stop it

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

go.nature.com

In commentary published in Cancer Cell, @danafarber.bsky.social’s @judithagudo.bsky.social contends that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and address resistance to immunotherapy. bit.ly/496Mc0Y.

Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!

Çağrı Çevrim@cagricevrim.bsky.social · 12mo ago

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉 @karalmckinley.bsky.social We built the first transgenic model of menstruation in mice. We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪 www.biorxiv.org/content/10.1... 🧵

Congrats! Indeed, so beautiful!

Idoyaga Lab@idoyagalab.bsky.social · last yr.

Our paper made the cover of Nature Immunology’s September issue! 🎉 Aren’t dendritic cells beautiful? 😍 SEM shows pDCs as they switch identity into cDC2-like cells. Congrats to the whole team! 👏 🔗 www.nature.com/ni/volumes/2...

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Interferons in health and disease

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

cell.com

Bone appetite: bone-derived factors feed distant immune suppression

Bone appetite: bone-derived factors feed distant immune suppression

The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopontin (OPN) production, which suppressed immunity in distal lesions. This highlights a novel cross-organ communication hindering antitumor immunity.

dlvr.it

www.sciencedirect.com/science/arti... Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social

Bone appetite: bone-derived factors feed distant immune suppression

The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically…

sciencedirect.com

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

dlvr.it

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage

Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

science.org

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage www.science.org/doi/10.1126/... @science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social

PICI Investigator @judithagudo.bsky.social, PhD, was recognized with the 2025 CRI Lloyd J. Old STAR Award, one of immuno-oncology’s highest honors from the Cancer Research Institute (CRI). Congratulations, Dr. Agudo! www.cancerresearch.org/media-room/2...

Thanks to other support that enabled this recognition @parkerici.bsky.social the NYSCF and the department of defense breast cancer program

Judith Agudo@judithagudo.bsky.social · last yr.

Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social @dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social

Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social @dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social

CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute

The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...

cancerresearch.org

NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding

Thanks @reinacampos.bsky.social for inviting me to @lji.org and UCSD. This has been a super fun visit! it is so amazing and energizing to meet in person!

I look forward to hosting @judithagudo.bsky.social at LJI, please join us! snacks and **Free parking**

La Jolla Institute for Immunology (LJI)@lji.org · 2y ago

Coming up Apr. 9 @ 12 PM - from the LJI & UC San Diego Program in Immunology: Dr. Judith Agudo of the Dana-Farber Cancer Institute presents research on "Dissecting Immune Evasion: How heterogeneous phenotypes protect targeted cells" More info: bit.ly/41N1T9B #Immunology @ucsdhealthsci.bsky.social

Going through Green Card application now with current climate, just to add to the uncertainty on funding in research. I need some positive thoughts!

We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons. www.science.org/doi/10.1126/...

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules

A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.

science.org

Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

nature.com

So excited to see how quickly #StandUpForScience has grown from a single rally to rallies in 32 cities in 27 states and counting! Let's go! Thank you for your leadership @standupforscience.bsky.social! They also opened up a donation page 🧪 standupforscience2025.org/local-event-...

Local Event Information

Below are the state capitals and major cities (alphabetized by state) hosting official Stand Up for Science events. If your city is listed, a confirmed site leader—backed by our core team—is active…

standupforscience2025.org

When efforts on DEIB are at risk, all help is great. Plus, I love the bame of these awards. Sharing for those that may benefit, applying for a job requires preparation💪🏿💪🏾💪🏽💪🏼💪🏻

Angela Andersen@angelaandersen.bsky.social · 2y ago

🌟 Postdocs on the Job Market! 🌟 JEDI awards celebrate justice, equity, diversity, & inclusion in science & can give you expert feedback on your job application & CV before they're scrutinized by search committees. Let us help you shine! Next Deadline: March 10th lifescienceeditors.org/apply/

"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0