GOOD NEWS! Phase I clinical trial results out of John Hopkins show a first-of-its-kind vaccine designed to target common KRAS mutations was safe AND stimulated KRAS-specific T-cell responses in 90% of study participants who were at HIGH risk of developing pancreatic ductal adenocarcinoma (PDAC).
Pancreatic Cancer Vaccine Triggers Immune Response Before Tumors Develop
Phase I results show early promise for a vaccine designed to prevent pancreatic cancer in people at high risk of developing the disease.
insideprecisionmedicine.com
Everyone I know just wants a stable job where they get to use their creative and technical skills to make dope shit. Like everyone I know really, really just wants to work really hard to make really cool things, but everyone just want to burn all the money in the big plagiarism machine
Hey everyone. A reminder that the deadline for graphic article proposal for GPU Zen 5 is approaching quickly. Sharing knowledge is the best way to learn!
The Forge Interactive@theforge.dev · 2mo ago🎮Graphics Programmers! Ready to shape the future of advanced rendering? Submit your proposal for GPU Zen 5, the next volume in the acclaimed GPU ZEN series, today! 📅 Deadline: July 5, 2026 📩Submit to: gpuzen@theforge.dev 🔗 gpuzen.blogspot.com #GraphicsProgramming #Rendering #GameDev #Authors #GPU
Here's an easter egg in the new Lego Batman that I think all of you will REALLY appreciate. It's so good, I had to make a video.
RIP Bobby Prince. His music legacy will live on, making inspired music for Commander Keen, Wolfenstein 3D, DOOM, countless others. A true legend. And such a nice man, great musician, wonderful, fun-loving man, nothing but happy memories of him. A loss to the world.
I create a fun little video about my Mega Man Legends project! www.youtube.com/watch?v=Dqnt...
The Genius Behind Mega Man Legends' Timeless Look
YouTube video by Mercurial Forge
youtube.com
Heretic 2 got a brand new reverse engineered source port for modern systems featuring bug fixes, faster loading times and hud scaling for high resolutions. Playing Heretic 2 just became a lot easier. For the moment it's Windows only: github.com/m-x-d/Hereti...
The amount of important things about games, industry, and life that I've learned from Brenda, following her career and work and advocacy and activism and mentorship and involvements from afar - but also the times we've crossed paths for work, is staggering. www.kickstarter.com/projects/the...
Game On: A Feature Documentary about Brenda Romero
Help Theresa Loong finish her documentary about Brenda Romero: visionary designer and mentor, shaping the future of game creation!
kickstarter.com
I just released my video about the engine (and game) I've been working on. The engine is based on dynamic SDFs, and the video describes how it works and what it makes possible. Link in the reply! This is my first YouTube video and it took forever - please repost!
had to wait until the servers weren't so overloaded, but I'm proud to announce that Quake Brutalist Jam 3 is out now! there's a standalone version that works like a game for those who don't own quake too! www.slipseer.com/index.php?re... this was a tremendous group effort, I couldn't be happier!
Jam - Quake Brutalist Jam III
Quake Brutalist Jam III is a megalithic community project more than a year in the making. It features an entirely new arsenal, a set of new monsters, new powerups, and a complete visual overhaul of Qu...
slipseer.com
Start the new year with a really big SDL3 release! 3.4.0 finally shipped, before the stroke of midnight! github.com/libsdl-org/S...
Release 3.4.0 · libsdl-org/SDL
Thanks to all the people who have contributed, SDL 3.4.0 is now available! In addition to lots of bug fixes and general system improvements, this release has some major themes of improved interoper...
github.com
🎉 Happy New Year! 🎉 May everyone have the strength to make 2026 a good one, no matter what.
I’ve been in game dev for 26 years and I can’t remember any other time where a specific tech was being insistently and persistently pushed on devs as a group in the public sphere. Why would it? Cui bono? Why would any given dev have an interest in other devs using tech they don’t have a stake in?
Zach Soares@voxels.ca · 8mo agoMy conspiracy theory about genAI in games blowing up more and more by big companies is that they’ve all got a ton of investors insisting they use genAI tools otherwise they(investors) won’t be able to bankroll em anymore
Why wait for new year to get started if you can just start today.
a man is standing in front of a green screen with his eyes closed
Alt: shia labeouf doing to 'just do it' stance
media.tenor.com
Chris Person takes a look at Horses, "the indie game that is too scandalous for either Valve or Epic, is only beyond the pale if you're not familiar with any other art form" (quoted from the article blurb). aftermath.site/horses-indie... At least read this paragraph:
GAME DEVS! GAME JAMMERS! ONE MONTH AWAY from this holiday's easiest jam -- TOY BOX JAM! You get a huge pile of gfx, sfx, music -- what will YOU make with all these toys? Join here! itch.io/jam/toy-box-... #toyboxjam2025 #gamejam #pico8 #unity #godot #GameMaker #love2D
Newgrounds is down for updates but in the meantime you can watch this five-part YouTube series about Newgrounds: www.youtube.com/watch?v=ed5Z...
Newgrounds, Old Memories Ep 1
YouTube video by Ringo's Ghost
youtube.com
To honor Ozzy's larger-than-life rock and roll legacy, we're making Brütal Legend *FREE* on itch.io: doublefine.itch.io/brutal-legend But this incredible deal will only last for 666 minutes, as the prophecy foretold. So get yourself clicking, before it disappears like a demon in the night... 🤘 🖤
PNG is back! After over two decades, we released a new PNG spec. www.programmax.net/articles/png...
PNG is back!Rec. 2020 and Rec. 709 comparison
After 20 years, PNG is back with renewed vigor! A new PNG spec was just released.
programmax.net
I did a long interview with the Full Time Game Dev and it turned out great. I get to rant freely for 1.5 hours, and I got to say a lot of fun stuff. Thanks so much to @thomasbrushdev, and take a look! www.youtube.com/watch?v=F9zY...
Jeff Vogel: Making Games Alone For 30 Years, Unity vs Custom Engine, Indie Survival | Ep. #046
YouTube video by Thomas Brush
youtube.com
This is a thread about me switching to Linux, after nearly 30 (!) years of using Windows. I need to make games on that thing too, so I hope it works There are many reasons for this, but tl;dr reason is that Windows is getting in my way. It's being a hindrance. An obstacle. It should be transparent.
a person riding on the back of a penguin
ALT: a person riding on the back of a penguin
media.tenor.com
Basically 12 tips from Mike Acton on how to get shit done. medium.com/@mike_acton/...
12 tips for making the best use of your time
Some tips that have worked for some people, some of the time, for some common problems. YMMV.
medium.com
Indie game devs! Worried you don't have a good publishing deal? May I present my firm's 2025 Publishing Agreement Data Report! Taken from 100+ actual Publishing Agreements ranging from 2017-2025, providing averages for rev share splits, advances, IP ownership and more! indiegamepublishing.com
EA just open sourced Command & Conquer, Red Alert, Renegade and Generals #EA #RTS #RedAlert #OpenSource #Gaming #CommandandConquer
EA just open sourced Command & Conquer, Red Alert, Renegade and Generals
I can't quite believe it either. Command & Conquer, Red Alert, Command & Conquer Renegade and Command & Conquer Generals (inc. Zero Hour) have their code officially open sourced.
gamingonlinux.com