Emmy Li
@emmyli.bsky.social
Postdoctoral Fellow @ Stanley Qi Lab Extreme dog lover. Fan of both land and marine wildlife. For dog pictures - @doodlycharlie on instagram
Stand up for science - stand up for the NIH! I just signed the support letter for the #BethesdaDeclaration. Please consider signing as well: www.standupforscience.net/bethesda-dec...
Bethesda Declaration — STAND UP FOR SCIENCE
Support NIH Staff Now!
standupforscience.net
New CRISPR technology developed by @stanleyqilab.bsky.social, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:
New CRISPR technology could help repair damaged neurons
Stanford researchers have developed a technology that delivers RNA to damaged neurons and stimulates regrowth – paving the way for potential treatments targeting neurodegenerative diseases like ALS…
news.stanford.edu
www.nature.com/articles/s41...
Programmable control of spatial transcriptome in live cells and neurons - Nature
CRISPR-TO, a system for programmable control of spatial localization of cellular RNAs, is presented and enables functional investigation of endogenous RNA localization in diverse living cells.
nature.com
Thrilled to share our paper in @nature.com led by @MengtingHan123 on CRISPR-TO technology, which paves the way for treatments for neurodegenerative diseases by precisely delivering therapeutic RNA to the damaged sites. A 🧵@Stanford_ChEMH, @bioe_stanford, @Stanford
Institute Scholar Stanley Qi @stanleyqilab.bsky.social discusses the importance of scientific research and his long-term goal of using the genetic engineering technologies developed in his lab to address unmet medical needs in diseases like cancer and Alzheimer’s:
‘For many people, waiting is not an option’
Stanford bioengineer Stanley Qi is developing advanced gene-editing tools to treat life-threatening diseases and slow the onset of neurological aging.
news.stanford.edu
“Research is like a chemical reaction – it takes time to reach completion. If we ever slow down in training the next generation of scientists, we risk falling behind other competitors in the world – even if we have the better solution.” #ResearchMatters
‘For many people, waiting is not an option’
Stanford bioengineer Stanley Qi is developing advanced gene-editing tools to treat life-threatening diseases and slow the onset of neurological aging.
news.stanford.edu
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation. www.biorxiv.org/content/10.1...
Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...
biorxiv.org
Grant freezes versus terminations feel different, but they have the same practical effect. We should start treating freezes as terminations, both of which can be undone by HHS / NIH whenever they want—or by court order if they refuse. They’re all illegal.
Cathy Gao-Howard MD MS@catgaohow.bsky.social · last yr.Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
No bottlenecks with binseq... github.com/ArcInstitute...
GitHub - ArcInstitute/binseq: A high efficiency binary format for sequencing data
A high efficiency binary format for sequencing data - ArcInstitute/binseq
github.com
Seth Stadick@ducktapeprogrammer.bsky.social · last yr.Moving the counter back to zero days since parsing fasta/fastq was the bottleneck.
LA trash haulers are bringing their loads up to the Antelope Valley and dumping it. I saw a river canyon filled -- 30 feet deep and about 60 acres in area -- of solid trash. www.latimes.com/science/stor...
Antelope Valley residents say they are fed up with rampant dumping, official inaction
Thousands of tons of trash are being dumped at unauthorized waste sites across the Antelope Valley, lawsuits claim. Authorities say they are aware but have done little to stop it.
latimes.com
www.biorxiv.org/content/10.1...
Genome-wide mapping of mesoscale neuronal RNA organization and condensation
Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...
biorxiv.org
🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social! 🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬
The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin
By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription factor REST. PBAF is ...
cell.com
Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇
Michael Montgomery@michaeltmont.bsky.social · last yr.I am elated to share that our manuscript describing Variant-EFFECTS, a high-throughput technology we developed to precisely and quantitatively measure the effects of CRISPR-mediated edits on gene expression, is now published at @cellpress.bsky.social: authors.elsevier.com/c/1kxgiL7PXu...
Losing sleep over #iPSC transgene silencing after differentiation? Same here — too many times😭 So we built a PiggyBac construct that resists silencing. Expression stays ON, even after differentiation. Our #preprint is out👇 🔗 www.biorxiv.org/content/10.1... Supported by @cziscience.bsky.social
Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation
While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...
biorxiv.org
Glad to share our paper, in collaboration with Prof W.E. Moerner lab and Prof. Andrew Spakowitz lab on developing a high-resolution DNA imaging technology Oligo-LiveFISH, which is online in Cell this week.
Stanley Qi@stanleyqilab.bsky.social · last yr.Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social
Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!
Takeshi Uenaka@tuenaka.bsky.social · last yr.Losing sleep over #iPSC transgene silencing after differentiation? Same here — too many times😭 So we built a PiggyBac construct that resists silencing. Expression stays ON, even after differentiation. Our #preprint is out👇 🔗 www.biorxiv.org/content/10.1... Supported by @cziscience.bsky.social
Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social
I'm excited to release what I've been cooking up the past few months at @arcinstitute.org BINSEQ is a family of binary file formats for sequencing data built with paired records and parallel processing in mind with big performance gains (2x-40x) over gzip-fastq with similar storage
bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · last yr.BINSEQ: A Family of High-Performance Binary Formats for Nucleotide Sequences https://www.biorxiv.org/content/10.1101/2025.04.08.647863v1
They’re destroying federal science capacity & California needs to step up & expand science capacity at the state level. I introduced SB 829 to create the California Institute for Scientific Research & authorize the State of California to produce vaccines. It just passed the Senate Health Committee.
As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up. I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵
Women are twice as likely to develop Alzheimer’s disease as men. A feature in Nature Medicine reports how the changes to the female brain during menopause, along with social and cultural factors, might affect disease risk. #medsky #alzsky 🧪
Women twice as likely to develop Alzheimer's disease as men - but scientists do not know why - Nature Medicine
Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.
go.nature.com
Despite @governor.ca.gov 's past concern about #plastic, #styrofoam can still be purchased in stores and online throughout CA. It was banned on Jan. 1. But the gov's office still has not acknowledged it, leaving some stores and producers confused. 🤷♀️ #SB54 www.latimes.com/environment/...
California banned polystyrene. So why is it still on store shelves?
Expanded polystyrene foam, the white fluffy plastic in styrofoam, was banned in food service ware on Jan. 1. But shoppers in CA say its still on the shelves.
latimes.com
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
