This was a truly interdisciplinary team effort w/ expertise across neuroscience, immunology & NDD. Huge thanks to everyone involved including our collaborators in labs of Menna Clatworthy, @lignanilab.bsky.social, Tarja Malm, Victor Tybulewicz, @macaskillaf.bsky.social & @movahedilab.bsky.social

Soyon Hong@soyonhonglab.bsky.social · 4w ago

Thrilled to share: we show that neuronal hyperactivity drives C1q-mediated synapse loss via brain-recruited B cell/IgM, revealing unexpected neuroimmune crosstalk in the adult brain. Congrats to Gerard Crowley who led this w/ resilience & creativity & our whole team! www.science.org/doi/10.1126/...

Thrilled to share: we show that neuronal hyperactivity drives C1q-mediated synapse loss via brain-recruited B cell/IgM, revealing unexpected neuroimmune crosstalk in the adult brain. Congrats to Gerard Crowley who led this w/ resilience & creativity & our whole team! www.science.org/doi/10.1126/...

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain uncle...

science.org

Immune cells target hyperactive neurons to eliminate synaptic connections @science.org @soyonhonglab.bsky.social @ucl.ac.uk www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

We’re looking for a postdoc to join us @ukdri.ac.uk @uclqsion.bsky.social! Strong immunology background to study neuroimmune interactions along gut–brain axis in Parkinson’s, supported by @wellcometrust.bsky.social. Collegiality & team spirit are a must. Info: lnkd.in/eZSyHjND. Please help share 🙏

So great that this paper is finally out! Happy that I was able to contribute to this important study. Congratulations @seppedeschepper.bsky.social, @soyonhonglab.bsky.social, Tim Bartels and all co-authors!

Nature [Unofficial]@nature.com.web.brid.gy · 6mo ago

New research has revealed how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice co-led by Dr @soyonhonglab.bsky.social & Dr Tim Bartels @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social

Targeting the gut's immune system could tackle early stages of Parkinson's

New research reveals how Parkinson’s spreads from the gut to the brain, with the help of immune cells – offering a new potential therapeutic strategy – in a study in mice led by scientists at the UK D...

ucl.ac.uk

Our paper is finally out! We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain www.nature.com/articles/s41...

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

nature.com

🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!

UK Dementia Research Institute@ukdri.ac.uk · 6mo ago

Could targeting the gut's immune system tackle the early stages of Parkinson's? 🧠 A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells. Read more 👉 www.ukdri.ac.uk/news-and-eve...

Absolutely thrilled & grateful to be awarded this prestigious ERC grant. None of this would have been possible without the remarkable team in my lab, past & present! Excited for the next steps of this important project.

European Research Council (ERC)@erc.europa.eu · 8mo ago

The results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu

Very excited and honored to join the Warsaw glia symposium- can’t wait to learn more about and discuss together the beauty and the complexity of glia with the community!

The Warsaw Glia Community@warsawgliacomm.bsky.social · last yr.

We're back with another exciting session — this time, spotlight on microglial cells! And wait until you see our star-studded lineup of speakers! Don't miss it — join us and stay at the forefront of the latest research! @soyonhonglab.bsky.social #WGC #GLIA

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

cell.com

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Immunity@cp-immunity.bsky.social · last yr.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!

Immunity@cp-immunity.bsky.social · last yr.

Online now: Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko See below for details and preprint

Mike Dolan@dolanmjg.bsky.social · last yr.

How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. www.biorxiv.org/content/10.1... Details below 👇

💪💪💪 @blurtonjoneslab.bsky.social sooo cool!

Gan Lab@liganlab.bsky.social · last yr.

Exciting work @blurtonjoneslab.bsky.social: CRISPR-engineered iPSC-microglia use the plaque-responsive CD9 promoter to deliver Aβ-degrading neprilysin across the brain-- reducing plaques, inflammation & synaptic loss. A promising new cell therapy platform for AD www.sciencedirect.com/science/arti...

Super fascinating!! Congrats, Tomás!!!

Tomás Ryan@tjryan.bsky.social · last yr.

Excited to share our new study: "Cold memories control whole-body thermoregulatory responses" by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social www.nature.com/articles/s41...

I've #justsponsored Selina Wray, who's fundraising for Alzheimer's Research UK on @JustGiving. Donate now: www.justgiving.com/page/selina-...

Selina's fundraiser for Alzheimer's Research UK

Help Selina wray raise money to support Alzheimer's Research UK

justgiving.com

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

WEBseq

share freely

webseq.net

Day 2 Session 7 #ImmuneDynamics at #BarrierTissues #gut_brain in #neurodegeneration with Michal Schwartz Soyong Hong Sandro Da Mesquita Elizabeth Bradshaw & Ryan Hobson

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10.... 👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social

Lipids: Emerging Players of Microglial Biology

Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...

onlinelibrary.wiley.com

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

nature.com