Worboys Lab
@worboyslab.bsky.social
Cellular Immunology/Cell Biology Lab at the University of Manchester, UK https://worboyslab.com
I have a technician post available in my lab and am looking for a passionate and ambitious team player to join our group. If you're interested in the role, please get in contact. www.jobs.manchester.ac.uk/Job/JobDetai... @lydiabeckeriii.bsky.social
Research Technician:Oxford Road
jobs.manchester.ac.uk
Really interesting findings and beautifully executed experiments! PD-1 signaling and PD-1 blockade–mediated tumor control are established at microvillar T cell contacts | Science Immunology www.science.org/doi/10.1126/...
PD-1 signaling and PD-1 blockade–mediated tumor control are established at microvillar T cell contacts
Microvillar contacts serve as sites of TCR and PD-1 signal integration, modulating T cell activation and tumor control.
science.org
This new type of immunotherapy shows promise for treating different cancers including prostate cancer, leukaemia and lung cancer.
Masked T-cell engagers: cancer immunotherapies for the future?
This new type of immunotherapy shows promise for treating different cancers including prostate cancer, leukaemia and lung cancer.
tcnv.link
A promising advance in mass spectrometry, inspired by a natural biological process! This will surely provide even greater depth of sequencing. www.science.org/doi/10.1126/...
A nature-inspired ion trap for parallel manipulation of ions on a massive scale
A nature-inspired ion trap enabling massively parallel mass spectrometry.
science.org
An article @sheencr.bsky.social and I wrote on the exciting promise of 'Masked' T cell engagers is now available at the Conversation. doi.org/10.64628/AB....
Masked T-cell engagers: cancer immunotherapies for the future?
This new type of immunotherapy shows promise for treating different cancers including prostate cancer, leukaemia and lung cancer.
doi.org
It was fantastic to contribute to the latest research from @owenlabuob.bsky.social now out at @natcomms.nature.com. This is a great initiative and could be an important resource for the SMLM community. www.nature.com/articles/s41...
Nano-org, a functional resource for single-molecule localisation microscopy data - Nature Communications
An open-access resource, nano-org, enables researchers to explore and compare the nanoscale 2 organisation of proteins imaged using single-molecule localisation microscopy, advancing insights 3 into cell biology, disease, and drug response.
nature.com
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
jobs.manchester.ac.uk
Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
🧩 Antigen presentation is complex - but imaging is bringing clarity. @doreenlau.bsky.social & @timmunologist.bsky.social review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity. 📖 https://bit.ly/3TkIasN #CancerImmunology
Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant: www.jobs.manchester.ac.uk/Job/JobDetai... #ChemicalBiology #SyntheticChemistry
Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road
jobs.manchester.ac.uk
Brilliant overview of ‘Click Biology’ rdcu.be/etLqI
Click biology highlights the opportunities from reliable biological reactions
Nature Chemical Biology - This Perspective discusses click biology as an analogy to click chemistry and examines reactions carried out using building blocks present in every living cell, enabling...
rdcu.be
🚨 The Menon lab is hiring a postdoc! Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases @ukri.org @lydiabeckeriii.bsky.social Please help spread the word #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in Mucosal Immunology :Manchester
jobs.manchester.ac.uk
Delighted to have visited the Dept. of Pathology at the University of Cambridge today to present our work. Some fantastic discussions!
More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226 www.nature.com/articles/s41... #immunosky
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis - Nature Communications
Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...
nature.com
The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com www.nature.com/articles/s41... www.nature.com/articles/d41...
The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!
Worboys Lab@worboyslab.bsky.social · last yr.We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!! #ChemSky #ChemBio www.findaphd.com/phds/project...
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation. #ImmunoSky www.biorxiv.org/content/10.1...
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
biorxiv.org
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti. To register your interest: www.biologists.com/meetings/jcs...
We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!! #ChemSky #ChemBio www.findaphd.com/phds/project...
(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com
PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com
findaphd.com
Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky
BSI committee elections 2025 | British Society for Immunology
immunology.org
Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation. #ImmunoSky www.biorxiv.org/content/10.1...
Inhibitory TIGIT signalling is dependent on T cell receptor activation
TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...
biorxiv.org
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function. Please get in touch if interested in applying. www.jobs.manchester.ac.uk/Job/JobDetai... #ImmunoSky #Imaging #Microscopy
Research Associate in Imaging Human Immunology:Oxford Road
jobs.manchester.ac.uk
New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work 🧪 Get in touch if you want to chat about life in the lab (it's fab)! www.jobs.manchester.ac.uk/Job/JobDetai... #ImmunoSky
Research Associate in Breast Cancer Metastasis:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ
jobs.manchester.ac.uk
Explore #CRISPR screening in our two-part course! #CRISPRAnalysis25 Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬 Focusing on: ▶️ #Oncology ▶️ #Neurodegeneration ▶️ #Immunology Apply by 3 June 📎Info: bit.ly/4iBpEah
Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function. Please get in touch if interested in applying. www.jobs.manchester.ac.uk/Job/JobDetai... #ImmunoSky #Imaging #Microscopy
Research Associate in Imaging Human Immunology:Oxford Road
jobs.manchester.ac.uk
A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential: www.frontiersin.org/journals/imm...
Frontiers | CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity
frontiersin.org
🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨
If you're a T cell enthusiast, check out our latest findings published recently in #Science Magazine | #Immunology. Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun. www.science.org/doi/10.1126/...
Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains
Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.
science.org
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
cell.com
