Kathryn Jacobs
@kathrynjacobss.bsky.social
Post doctoral fellow Bergers/Agostinis Lab Formerly member of Lab Soap Focus on Autophagy, Vessels, inflammation, and cancer
Our latest story from the @bergerslab.bsky.social out now in @cp-immunity.bsky.social cell.com/immunity/ful... #autophagy #upr #psoriasis #inflammation #HEV #highendothelialvenules
Autophagy maintains high endothelial venule identity and function during inflammation
High endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood. Jacobs et al. reveal t...
cell.com
💡Lymphatic endothelial cells aren’t just passive conduits. They control T cell egress via autophagy & S1P, and can make or break immunotherapy. Read the article by Diede Houbaert, @kathrynjacobss.bsky.social, and @agostinislab.bsky.social 🔗: sciexplor.com/exo/articles... #tumorimmunology #autophagy
Check out our latest review on lymphatic vessels in cancer ! @agostinislab.bsky.social #autophagy #lymphatics #immunotherapy #antitumorimmunity www.sciexplor.com/articles/EXO...
The lymphatic endothelial-immune dialogue in cancer and immunotherapy
Lymphatic endothelial cells (LECs) and the lymphatic vasculature have evolved from being viewed as passive conduits for fluid drainage and metastatic dissemination to active, dynamic regulators of inf...
sciexplor.com
🧠🔬Targeting #celladhesion #JAMC to limit #glioblastoma #stemcell #invasion 📄 @cellpress.bsky.social www.sciencedirect.com/science/arti... 🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA
Check out our preprint on #autophagy in #HEVs during #Inflammation www.biorxiv.org/content/10.1...
Autophagy maintains HEV identity and function during inflammation
High endothelial venules (HEVs) play a crucial role in adaptive immune responses in secondary and tertiary lymphoid organs. They are uniquely equipped with high levels of peripheral node addressins (P...
biorxiv.org
Thank you to the organizers of @keystonesymposia.bsky.social Autophagy meeting for the opportunity to present my post doc work #autophagy #Hevs
👋Our June issue's out! Cover: #Ferroptosis hotspots 👉🏼Editorial on #microscopy reporting 👉🏼Review on #mitochondria membrane 🔬 #cholesterol transport #neutrophils #exosomes #CellDeath #RNA #DNArepair #BreastCancer #ExtracellularVesicles #peroxisome proteins & more! www.nature.com/ncb/volumes/...
Super grateful to see our image on the June cover of @natcellbio.nature.com representative of our work www.nature.com/articles/s41...! Many thx to @agostinislab.bsky.social and the editorial team ❤️🔥 www.nature.com/ncb/volumes/... @viblifesciences.bsky.social @kuleuvenuniversity.bsky.social
Agostinis Lab@agostinislab.bsky.social · last yr.Honored to have our image @mariamls.bsky.social featured on the June cover of NCB! It's a stunning depiction of #ER-mitochondria hotspots in #ferroptosis. Huge thanks to @natcellbio.nature.com team for this awesome recognition of our work. @viblifesciences.bsky.social www.nature.com/ncb/volumes/...
Honored to have our image @mariamls.bsky.social featured on the June cover of NCB! It's a stunning depiction of #ER-mitochondria hotspots in #ferroptosis. Huge thanks to @natcellbio.nature.com team for this awesome recognition of our work. @viblifesciences.bsky.social www.nature.com/ncb/volumes/...
🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
doi.org
Check out this super new study from @mariamls.bsky.social and @agostinislab.bsky.social studying the role of ER-mito contact sites in #ferroptosis www.nature.com/articles/s41...
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
nature.com
💥 New study : check out @katkajerabkova.bsky.social Katka's wizardry in the lab 🧙♂️ Building on the #Nanotumor consortium that we launched few years back, we now provide solid evidence that melanoma cells' inner architecture controls the progression of #melanoma to #metastasis rdcu.be/eg8EU (1/3)
Peripheral positioning of lysosomes supports melanoma aggressiveness
Nature Communications - The function and position of organelles are pivotal for tumor cell dissemination. Here the authors use melanoma patient samples and animal models to show that peripheral...
rdcu.be
Had a great time at Cfatg’s autophagy meeting ! Thanks to the organizers for the opportunity to speak ! @cfatg.bsky.social
Interested in studying HEVs but don’t know where to start? We’ve created some helpful tips to get you started. www.sciencedirect.com/science/arti...
Guidelines for the assessment of high endothelial venule functionality and health
High endothelial venules (HEVs) are specialized blood vessels that act as the entry point for lymphocytes into the lymph node. These vessels have a un…
sciencedirect.com
👀 📝 Words of Advice #co-development #postdocs @febspress.bsky.social @tiphainedouanne.bsky.social @laisbfugio.bsky.social #JaneJardine #QuentinRoux @sararosinska.bsky.social in @labsoap.bsky.social @nbidere.bsky.social @insermgrandouest.bsky.social febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
‘Who in their right mind would add another meeting to an already overflowing schedule?’ This thought crossed our minds when we first discussed the idea of a postdoc peer group meeting. We are five ea....
febs.onlinelibrary.wiley.com
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
