Katie Pickup

@katiepickup.bsky.social

🧬 Reviews Editor @biologists.bsky.social 👩🏻‍🔬 PhD epigenetics & differentiation @uoe-igc.bsky.social Views my own | she/her

Thanks @jcellsci.bsky.social and @katiepickup.bsky.social for the opportunity! It was fun to reflect on the years I spent in different labs and institutes.

Journal of Cell Science@jcellsci.bsky.social · 2mo ago

Our Cell Scientist to Watch is Mu He @mh-lab.bsky.social. We spoke to Mu over Zoom to discuss her research career, the challenges of establishing a lab under pandemic restrictions and the importance of balance in life. journals.biologists.com/jcs/article/...

Mu He

Beyond proteins and DNA, #lipids are emerging as key players in nuclear biology - shaping nuclear envelope dynamics, mechanosensing, gene regulation and genome stability. Our new Perspective highlights recent advances, open questions, and future directions 👉 journals.biologists.com/jcs/article/...

Emerging roles of lipids in nuclear function and homeostasis

Summary: Lipids are increasingly recognized as essential regulators of nuclear homeostasis, membrane dynamics, mechanotransduction and genome stability, opening new frontiers for understanding nuclear...

journals.biologists.com

It was a pleasure to speak to @harmitmalik.bsky.social and feels very hopeful to have people like him as leaders in science journals.biologists.com/dmm/article/...

Harmit Singh Malik@harmitmalik.bsky.social · 4mo ago

I was interviewed by @katiepickup.bsky.social recently for @dmmjournal.bsky.social. This has a little bit of my background, a little bit on science and mentoring, and a little bit (ok, more than a little bit) on funding in science. Check it out at: journals.biologists.com/dmm/article/...



How important do you feel discovery research and ‘basic’ science is for understanding disease?

Well, I have a little bit of a biased view on the topic, since I'm a basic scientist myself. The lab has made more and more discoveries with very strong therapeutic implications, and often people ask me why we are not pursuing these further ourselves. Part of it is that I think about this very much as an ecosystem. People have different skills – I have colleagues who are very good at the application side of things and I have other colleagues, including people in my lab, who are very good at the basic science. There are a lot of very smart people at every stage in the ecosystem and, sometimes, we have to acknowledge that we can't all be experts in every step. A lot of basic science discoveries will end up having profound implications in the clinic – if you don't have the full imagination about how to get it there, that's okay, because you're still a very important piece of the jigsaw puzzle and other people can help. If the basic science discoveries didn't exist, then it's quite possible that the well would run dry. We cannot simply rely on the idea that the therapies currently in clinical trials are going to be enough because we already know that – for diseases, such as cancer, and with rapidly evolving viruses – there needs to be a constant influx of new ideas to stay ahead of the arms race. I'd also make a plug for the fact that, ultimately, we are all interested in human disease, but disease research in humans is not ethical or possible. This is why creating and studying model organisms in a high-throughput, low-investment context is incredibly important. We cannot just say ‘okay, we're going to stop work on anything that is not related to human research’, because – actually – it's all relevant to humans.

Do have a read of this call to action from a fantastic bunch of ECRs working in the cell biology-climate space @cells4planethealth.bsky.social It's full of lots of important ideas to support future research and researchers who want to use cell biology to help reach a more sustainable future

Journal of Cell Science@jcellsci.bsky.social · 7mo ago

Cell biology for a sustainable future – a call to action from Camila Costa, Eliott Flaum, @dhlashwayo.bsky.social, Marie Jacobovitz, Guillermina Kubaczka, Samuel Lovat, Eliya Milshtein, @hannaszafranska.bsky.social and @sorayazwahlen.bsky.social. journals.biologists.com/jcs/article/...

Drawing showing that planetary cell biology is a field that combines environmental sciences and cell biology. Understanding cellular function and its environmental context can be useful in explaining larger-scale systems operating at the multicellular and ecological levels. Furthermore, planetary cell biology provides key insights into how biological systems might adapt, be resilient to, and even mitigate, environmental perturbations associated with the climate crisis, such as changes in temperature, pH, pressure and other conditions.

I really enjoyed talking to Peggy - it was great to revisit the world of DNA methylation and stem cells as well as learn more about the blood and ageing 🩸

DMM Journal@dmmjournal.bsky.social · 7mo ago

In this interview with Margaret (Peggy) Goodell @goodell-lab.bsky.social we discussed her impressive career, the parallels between ageing and cancer in the blood, and the lessons we can learn from stem cell biology to understand and mitigate disease. doi.org/10.1242/dmm....

Photograph of Peggy Goodell

Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb. More at: www.biologists.com/about-us/wor...

Work for us

Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...

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