Katreya Lovrenert
@katreya.bsky.social
Computational Biology Manager for the Institute for Glial Sciences at Case Western Reserve University
“Super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting” www.cell.com/cell-genomic...
Single-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting
Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...
cell.com
It would be nice to have people in charge who weren’t totally insane
Phenomenal paper from our @gladstoneinst.bsky.social and @ucsanfrancisco.bsky.social colleagues on protein-protein interactions of autism-related proteins. www.science.org/doi/10.1126/...
Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology
Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease ...
science.org
Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭 www.nature.com/articles/s41...
Want to keep her memory alive? Do a lot of kind things, for a lot of people, no matter who they are. And do it with a happy and humble heart.
Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n
Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature Biotechnology
High-dimensional data are visualized through representation on tree structures.
nature.com
Erik van Nimwegen@erikvannimwegen.bsky.social · last yr.Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...
🌘 What does a solar eclipse look like from space? The four Artemis II astronauts witnessed this stunning sight, and thanks to a camera on the spacecraft's European-built solar arrays, the rest of us can enjoy the view too 😎. 📸 NASA
"My Lord! Gondor calls for Reviewing their manuscript in 7 to 12 days!"
King Théoden: And Rohan Will Answer
Alt: King Théoden: And Rohan Will Answer
static.klipy.com
MadScientist@mads100tist.bsky.social · 3w agoThat "Gondor calls for aid" scene, but it's about a manuscript submission
Here's a new kind of virus that scientists have generated with AI. And here's my story about what it means for us to have gotten to this remarkable moment: nyti.ms/4bBhoWB (Gift link) 🧪
Looks like a seahorse, but it’s not. It evolved the same body plan independently! journaloflostspecies.org/index.php/jl...
On August 1, 1931, Harriet Creighton and Barbara McClintock published the first experimental proof that genes are physically located on chromosomes—a discovery that transformed genetics. 1/3🧵
No professional accomplishment has ever made me happier than this. theonion.com/translator-o...
Translator Of Original ‘Minions’ Epic Poem Slams ‘Sexless, Bloodless’ Film Adaptation
PHILADELPHIA—In a 4,500-word essay published in Harper’s Magazine, Emily Wilson, known for her popular translation of the Minions epic poem, blasted the latest film Thursday as a “sexless, bloodless” ...
theonion.com
🚨 Something big is coming! 20 years after the discovery of #iPSCs, we're sitting down with the scientist behind it all. Dr. Shinya Yamanaka, @nobelprize.org Laureate, joins us to discuss the discovery that changed regenerative medicine and where we're headed next. 📃 https://bit.ly/4vQnpFX
4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...
Contents | Science 393, 6809
science.org