It was fun to write this review with @rcdrula.bsky.social on Dicer functions beyond the canonical RNAi roles, including discussion of its roles in the nucleus. An evolving and sometimes complicated field, that was synthesized beautifully by Rareș, a terrific postdoc in the lab. Check it out!

Noncanonical Functions of DICER-Mediated Pathways

Dicer has long been viewed as the RNAse III enzyme that generates small regulatory RNAs to drive RNA interference (RNAi) machinery and posttranscriptional gene silencing. However, a growing body of ev...

annualreviews.org

In our new collaborative paper on IDHmutant glioma with the Tirosh, Suva, Iavarone and Lasorella labs, we show how acquired genetic alterations converge with cell state changes and poor treatment responses. www.nature.com/articles/s41...

Acquired genetic and cell-state changes in IDH-mutant glioma progression - Nature

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

nature.com

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Delighted our work on chromosomal instability in oesophageal cancer is now out in Science Advances share.google/UcZXne5OZdM9...

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis

Chromosomal chaos rewires immune defense into tumor-promoting inflammation.

share.google

Parkes lab pre-print alert! ‘TMEM33 deletion potentiates anti-tumor CD8⁺ T cell immunity.’ Led by mtjackson101.bsky.social. Full bluetutorial follows! 1/10 www.biorxiv.org/content/10.6...

The Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!

Kim Lab at UC Irvine

Visit the post for more.

sskimlab.org

Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪 #academicSky www.nature.com/articles/d41...

More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

nature.com

Very happy that the review article by @magnushaughey.bsky.social and Imran Noorani on the evolutionary role of extra-chromosomal DNA in cancers just came out. authors.elsevier.com/sd/article/S...

🚨The formation of 3D chromatin hubs is a poorly understood phenomenon. I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures. rdcu.be/elPt3

Decoupling chromatin hubs from gene control

Nature Structural & Molecular Biology - Chromatin hubs, which are formed during cell differentiation, are characterized by simultaneous interactions between multiple regulatory elements and...

nature.com

Excited to share our latest manuscript www.biorxiv.org/content/10.1... This was a great collaboration with Drs. Huse, Lang, @jesserdixon.bsky.social

Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...

🧪 We’re Hiring: Lab Technician 🧪 I’m happy to share that our newly established Emmy Noether Group in Essen is looking for a Lab Technician to join our team! 🔗 Apply here: karriere.ume.de/job-finder/?... 📅 Start: At the earliest possible date 💻 Homepage: kocakavuklab.vercel.app/overview

that’s right

Kat O’Brien@lavidagata.bsky.social · last yr.

I knew the U.S. higher education system was a massive draw for foreigners, but I did not know the U.S. sold more educational services to the rest of the world than it did natural gas and coal combined. Great piece by @crampell.bsky.social

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

Flora Rutaganira@frutag33.bsky.social · last yr.

Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Nature Genetics is looking to hire a new editor! Come join our team and help publish the most exciting research in genetics and genomics! Deadline is April 25th. springernature.wd3.myworkdayjobs.com/en-US/Spring...

Associate or Senior Editor Nature Genetics and Nature Communication

Job Title: Associate or Senior Editor Nature Genetics and Nature Communication Organisation: Nature Portfolio Location: New York/Philadelphia, Shanghai/Beijing, Madrid or Milan Application Deadline: A...

springernature.wd3.myworkdayjobs.com

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Rules of Engagement

YouTube video by Johan Gibcus

youtube.com

Lookin for a good read in between experiments? Check out the commentary article in @neuroonc.bsky.social @dbayik.bsky.social and I wrote on an insightful study on myeloid cells in gliomas 🙂‍↔️ link here: academic.oup.com/neuro-oncolo...

An in-depth survey of immunosuppressive myeloid cell heterogeneity in GBM

Brandon Emanuel León, Defne Bayik; An in-depth survey of immunosuppressive myeloid cell heterogeneity in GBM, Neuro-Oncology, , noaf080, https://doi.org/10

academic.oup.com

This is truly heartbreaking! I don’t understand the “logic” behind all this. Hurting the US science will only make scientific enterprises of other countries stronger. Why an administration would want that?

Kelton Minor@keltonminor.bsky.social · 2y ago

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Cancer knows no borders, and setbacks in one part of the world can have lasting consequences for #patients everywhere The #EACR, and all co-signing national #cancer societies & foundations, stand in solidarity and offer our full support to our friends and colleagues in the US #StandUpForScience 🧪

EACR - European Association for Cancer Research@helloeacr.bsky.social · 2y ago

The EACR stands against threats to cancer research. Protecting scientific research is vital for progress and and the development of new treatments. Read our full statement in support of our friends and colleagues in the US: eacr.org/statement-on...

Happy to share our review with @akispapantonis.bsky.social in which we summarise and discuss our current understanding of enhancer-mediated gene activation in the context of the 3D genome: www.annualreviews.org/content/jour...

Review alert - "Modelling and design of transcriptional enhancers" by Seppe and Vasilis 👇

Seppe De Winter@seppedewinter.bsky.social · 2y ago

We wrote a review article on modelling and design of transcriptional enhancers using sequence-to-function models. From conventional machine learning methods to CNNs and using models as oracles/generative AI for synthetic enhancer design! @natrevbioeng.bsky.social www.nature.com/articles/s44...

Really excited to share our lab's first manuscript! I cant be more proud of our team, especially @nora-mae.bsky.social who diligently worked on this project. It will be a long thread but I promise it's worth it! #Oncology #BrainMets

medRxivpreprint@medrxivpreprint.bsky.social · 2y ago

Recurrent ERBB2 alterations are associated with esophageal adenocarcinoma brain metastases https://www.medrxiv.org/content/10.1101/2025.02.19.25322558v1

Timothy A. Yap, MBBS, PhD, has been appointed editor-in-chief of the AACR journal Clinical Cancer Research. Dr. Yap is co-director for the AACR/ASCO Methods in Clinical Cancer Research Workshop and a past cochair of the AACR Annual Meeting Clinical Trials Committee. www.aacr.org/about-the-aa...

Here is how random things affect your career: in Oct, I applied for my 1st R01. For study sections I recommended CG first and then GRIC. My grant was assigned to GRIC. It seems CG met last week but GRIC was cancelled today. Where should I put this information on my CV/biosketch?!

Annika Barber@annikabarber.bsky.social · 2y ago

Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...

For all the gains AI affords in compound design and discovery, experimental validation still remains a bottleneck. But we're making that part easy for the cancer target TBXT with a suite of biophysical, in vitro and in vivo assay capabilities—plus prizes for potent binders: tbxtchallenge.org

Chemistry World@chemistryworld.com · 2y ago

Will AI revolutionise drug design and discovery? Not the parts that count, says @dereklowe.bsky.social. Biology doesn’t care whether a drug was designed by a human or an algorithm, and there is no AI yet that can competently predict clinical trial outcomes. www.chemistryworld.com/opinion/robo...

Multiscale footprints reveal the organization of cis-regulatory elements www.nature.com/articles/s41... ▶️Footprints of DNA–protein interactions from bulk & single-cell ATAC-seq ⤵️ ▶️Deep learning to infer transcription factor and nucleosome binding ▶️Age-associated reduction of nucleosome footprints

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Snow day at the Zoo! ❄️ Lisa our Amur Leopard is choosing to explore the snow this morning. All animals are healthy and doing well. During the wintery weather, our animals have access to their heated barns prepped with extra hay. 📸: John R., Hoofstock & Carnivore Curator

Thrilled to welcome Ziya Gokaslan, M.D., from Brown University to deliver the 29th Annual Leavens Lecture at @mdanderson.bsky.social today! Dr. Gokaslan spoke on spinal surgery and #chordoma.