Kristina Micheva
@kdmicheva.bsky.social
Neuroscientist, array tomographist, learner of languages and martial arts
Here are my slides for #fens2026 “A versatile and affordable array tomography workflow” https://jekelylab.codeberg.page/FENS_Array_Tomography_Barcelona_July2026.html#/title-slide for the 'Expanding Horizons: Array Tomography in Neuroscience for All' […] [Original post on biologists.social]
It was a great talk, with a bonus subject of software monopoly, in addition to the future of a more accessible volume EM!
Gaspar Jekely@jekely.biologists.social.ap.brid.gy · 2mo agoFENS 2026 - the only file format the organisers accepted was pptx. I offered html, pdf - did not get far. In the end I gave a chalk talk (there was no chalk). Not good for #DigitalIndependence "The Document Foundation, creators of #LibreOffice and promoters of the OpenDocument format (ODF), has […]
Istanbul: The Synapse of Continents hosts FRM2027! Where East meets West, we are excited to announce that the FENS Regional Meeting 2027 will take place in Istanbul from 26–29 May.
Tend to agree. Work by us & @kdmicheva.bsky.social showed that a strangely high fraction (~50%) of myelin in upper layers of cortex wraps short lengths of fast-spiking, parvalbumin-positive basket cells. We suggested it was to support their axons, rather than to speed up spike time arrival.
A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons
Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
elifesciences.org
The Transmitter @thetransmitter.bsky.social · 3mo agoRecent findings suggest that myelin may serve as an energy reserve for the brain. In his essay, Carlos Matute argues that this should prompt neuroscientists to rethink how the brain stores, shares and protects energy in health and disease. #neuroskyence www.thetransmitter.org/metabolism/b...
From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 6mo agoA quantitative census of millions of postsynaptic structures in a large electron microscopy volume of mouse visual cortex https://www.biorxiv.org/content/10.64898/2026.02.19.706834v1
It is with a heavy heart that I share the unexpected news that our colleague, friend, and mentor Daniel Madison passed away on Thursday, October 9.
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
Back from a trip and I found this unintentional present I left myself
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!) thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
Nature Reviews Neuroscience@natrevneuro.nature.com · last yr.Synaptic connectomics: status and prospects — a Comment article by Davi D. Bock @dddavi.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...
Ultramicrotomy escapism: trimming blocks and enjoying the shapes and colors 💕
Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows. www.arraytomography.org/workshop-202...
Workshop 2025
About the workshop This workshop will cover array tomography (AT) technology with a focus on “simple and affordable” workflows based on serial ultramicrotomy and imaging. The practicals include...
arraytomography.org
We're thrilled to announce the largest private gift in our 137-year history: a $25 million unrestricted donation from MBL Whitman Scientist Mark Terasaki. His extraordinary generosity will bolster our renowned research and education programs. 🔬 Learn more: bit.ly/452WL1m
MBL Announces Largest Ever Gift for Its Renowned Biological Education and Research Programs | Marine Biological Laboratory
Cell Biology Researcher Mark Terasaki’s $25 Million Unrestricted Gift Will Support Operations and Infrastructure Contact: Samantha Cummis scummis@mbl.edu; 973.800.4119
bit.ly
Excited to announce registration to the next Array Tomography workshop in Buenos Aires is now open! #volumeEM See our AT website page for more information ⬇ www.arraytomography.org/workshop-202...
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
nature.com
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
Prasad Jallepalli, MD, PhD@prasad.bsky.social · 2y agoI’m very scared to see what happens to PubMed
What happened to the pursuit of truth? rupress.org/jgp/article/... - Eve Marder, on point...
What happened to the pursuit of truth? | Journal of General Physiology | Rockefeller University Press
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
rupress.org
Happy to share a new biorxiv manuscript with @owen-lab.bsky.social where we “slice and dice” synapses with array tomography and find subclasses with different glutamate receptor composition 🧪
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y agoData-driven synapse classification reveals a logic of glutamate receptor composition https://www.biorxiv.org/content/10.1101/2024.12.11.628056v1
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...
Get a free NIH BRAIN Initiative art calendar to prep for 2025: catalog.ninds.nih.gov/publications... . I'm proud to say that the cover is a piece we created from the DTI imaging of a subject in the BRAIN funded depression DBS study we reported last year: go.nature.com/48lmlzC 🧪🧠
Cortical interneurons learn on the job! Speculated this was true a decade ago! Sherry Wu and Min Dai finally provide evidence! www.biorxiv.org/content/10.1...
Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own researc...
biorxiv.org
Best thing you could watch in 2016 and best thing you can watch today. RIP Thomas Reese
Celebrating the small (70 nm) victories today - look at these perfect serial sections that I cut! 🧪 the joys of #arraytomography
Time for some of my favorite images with immunofluorescence array tomography: this one is human cortex, and the yellow fluff around the blue nuclei are lipofuscin granules that accumulate with aging. Lipofuscin in this image comes for free - no label needed because it is autofluorescent!
Delicious & unique array tomography cake from the Array Tomography Workshop in Munich 2024. Thank you!
There are places / communities / ecosystems that are so difficult to leave and keep pulling you back Woods Hole, MBL
