preprint🥳 Connectome-wide mega-analysis identifies a reproducible functional network signature of temporal lobe epilepsy -hypo+hyper connectivity -patient/site consistent -constrained by 🧠 wiring -tracks clinical status and info for outcome by @kexie.bsky.social et al doi.org/10.64898/202...

📢 Publication Alter! 🎉 Excited to share that our work, “Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy”, is now out in Nature Communications #TLE #MRI #biomarker 🔗 Full paper: rdcu.be/eQKLX 📣 Full post (credit to @borismontreal.bsky.social): bit.ly/48uJL7r

Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Nature Communications - Xie and colleagues show that MRI-based brain function maps can identify patient-specific abnormalities in temporal lobe epilepsy, track how they spread along brain networks,...

rdcu.be

Ke Xie@kexie.bsky.social · last yr.

✨ What makes the brain's functional organization different in each #TLE patient? 🧠 ✨ We used a large sample (298 healthy adults, 282 TLE, 45 disease controls) + normative modeling to capture individualized functional disruptions. 🔎 #epilepsy #neuroimaging #precisionmedicine doi.org/10.1101/2025...

🧠 Why do some brains age faster than others? 🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age. nature.com/articles/s43587-025-00962-7 Thread below 👇

Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging

This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.

nature.com

New work from the lab published in @cp-neuron.bsky.social by @jonasterlau.bsky.social and Jan Martini. We describe that trial-by-trial variability indexes recurrent connectivity across the cortical hierarchy, which supports reliable and flexible coding www.cell.com/neuron/abstr... (1/4)

Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain

Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the r...

cell.com

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function

Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

nature.com

🚨 New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG) Led by @jordandekraker.bsky.social docs: hippomaps.readthedocs.io paper: doi.org/10.1038/s415...

This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

nature.com

Excited to share such a career milestone 🌟 Our new @pnas.org paper shows how E–I balance drives dynamic brain adaptation. Thanks to @jorgejovicich.bsky.social, @dimitrivdv.bsky.social, @asiaferrari.bsky.social, @bcassone.bsky.social & amazing co-authors 🙏 🔗 www.pnas.org/doi/10.1073/...

Disentangling metabolic and neurovascular timescales supporting cognitive processes | PNAS

The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism su...

pnas.org

Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner Paper link: www.sciencedirect.com/science/arti...

Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

nature.com

New paper in Nature Biomedical Engineering by @timonmerk.bsky.social ! We built a platform that unites AI-based brain signal decoding with connectomics across 123 hours of recordings from 73 patients. A step toward adaptive, network-level neurotechnology. www.nature.com/articles/s41...

Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants - Nature Biomedical Engineering

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

nature.com

Interested in Epileptic Discharges? In need of a data set to validate your source reconstruction models based on clinical outcome? Check out our newest: www.nature.com/articles/s41... Big thanks to B. Vorderwülbecke, S. Vuillémoz et al. ! - @seeber.bsky.social @cibm.bsky.social

High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome - Scientific Data

Scientific Data - High-Density EEG Source Localisation of averaged interictal epileptic Discharges validated by surgical Outcome

nature.com

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world! 🔗: www.nature.com/articles/s41... 📄: rdcu.be/ex8hW

A neural manifold view of the brain - Nature Neuroscience

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

nature.com

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Alert! ... for the child development world! @fluxsociety.bsky.social @fitngin.bsky.social ‪ The Healthy Brain and Child Development (HBCD) Study has released its first data wave - it’s massive. Check here: docs.hbcdstudy.org and here: nbdc-datahub.org Here’s why it matters 🧠🍼

🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...

Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery - Kozma - Epilepsia - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery

Objective Drug-resistant focal epilepsy is associated with abnormalities in the brain in both gray matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abnormaliti...

onlinelibrary.wiley.com

Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities - Horsley - Epilepsia - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Seizure freedom after surgical resection of diffusion‐weighted magnetic resonance imaging abnormalities

Objective Successful epilepsy surgery requires accurate localization and removal of the epileptogenic zone. Neuroimaging helps detect structural brain abnormalities to guide surgery, but current cli...

onlinelibrary.wiley.com

RELEASE THE KRAKEN(CODER)! Ever struggle deciding which connectome pipeline to use or want to map between structure and function? Our multi-modal connectome mapping and fusion tool-the Krakencoder-can help! Brilliant Keith Jamison led this work, code available! www.nature.com/articles/s41...

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

The history and future of resting-state functional magnetic resonance imaging - Nature

This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...

nature.com

The gradients workshop is happening soon! Please join us on June 23rd in Brisbane for a full day of gradient fun! 🌈 ✅ Amazing speaker line up ✅ Poster presentation ✅ Flash talks for selected abstracts Deets on program, abstract submission, and registration 👉 gradients-workshop.github.io

First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ... www.nature.com/articles/s41... Read here: rdcu.be/ek01F

Autonomic physiological coupling of the global fMRI signal

Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

rdcu.be

My lab has two fully funded MSc/PhD positions available! * Cool research on neuroimaging, epilepsy, and brain development ⚡️ * Located in a brand new building with lots of natural light 🌱 * Worldwide collaborations 🤝🏼 * Fun and inclusive environment 🤩 Learn more and apply 👉🏼 slic-lab.github.io

Sherbrooke Laboratory for Integrative Connectomics | SLIC

Exploring cutting-edge research in neuroimaging, epilepsy, brain development, and so much more!

slic-lab.github.io

✨ What makes the brain's functional organization different in each #TLE patient? 🧠 ✨ We used a large sample (298 healthy adults, 282 TLE, 45 disease controls) + normative modeling to capture individualized functional disruptions. 🔎 #epilepsy #neuroimaging #precisionmedicine doi.org/10.1101/2025...

Personalized Biomarkers of Multiscale Functional Alterations in Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences in spatial pa...

doi.org

While the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N

Happy to share that our article “Human lifespan changes in the brain’s functional connectome” is now published online at Nature Neuroscience @natureneuro.bsky.social ! Many thanks to all collaborators & data contributors, and the editor team & reviewers! www.nature.com/articles/s41...

Human lifespan changes in the brain’s functional connectome - Nature Neuroscience

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...

nature.com

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications

Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.

nature.com

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com