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Frederic Schaper

@fredschaper.bsky.social

Instructor in Neurology, MD PhD | Neuroscientist at @braincircuits.bsky.social at Brigham and Women’s Hospital of MGB, Harvard Medical School | I’m Interested in neuromodulation, brain networks, and epilepsy

31 Posts659 Follower669 Folgt
Andreas Horn@andreashorn.org · last yr.

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

Lauren Hart@laurenahart.bsky.social · last yr.

🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...

Isaiah Kletenik@isaiahneuro.bsky.social · last yr.

Was fun to do a podcast about our recent paper on creativity and brain disease with Dr Norman Swan @abcnewsbot.bsky.social @braincircuits.bsky.social @foxmdphd.bsky.social @harvardmed.bsky.social www.abc.net.au/listen/progr...

What brain damage tells us about creativity - ABC listen

Scientists have long been aware of a paradox of neurodegenerative disease – that as the brain deteriorates, in some patients creativity flourishes. Researchers have used imaging techniques to map cre...

abc.net.au

Michael Fox@foxmdphd.bsky.social · last yr.

Lesions causing epilepsy map to a brain circuit, but what about generalized epilepsy? Great new paper (and thread) by @fredschaper.bsky.social identifies this circuit with implications for #DBS. @braincircuits.bsky.social

Frederic Schaper@fredschaper.bsky.social · last yr.

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

Frederic Schaper@fredschaper.bsky.social · last yr.

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

Andreas Horn@andreashorn.org · last yr.

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder

In the field of deep brain stimulation (DBS), two major themes are currently making significant progress. First, the framework of connectomic DBS, in which circuits that are associated with improvemen...

biologicalpsychiatryjournal.com

Michael Fox@foxmdphd.bsky.social · last yr.

Can brain damage change your political opinions? “No significant neuroanatomical circuit was associated with political ideology or party affiliation, but a distinct circuit was associated with intensity of political involvement” Work by @shansiddiqi.bsky.social @braincircuits.bsky.social

Shan Siddiqi@shansiddiqi.bsky.social · last yr.

Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social

Lead-DBS@lead-dbs.org · last yr.

Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!

Aperture Neuro@apertureohbm.bsky.social · last yr.

Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social

Nature Portfolio@natureportfolio.nature.com · last yr.

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.

go.nature.com

Michael Okun@michaelokun.bsky.social · last yr.

The 12th Annual Deep Brain Stimulation Think Tank Proceedings are out and free to download. Check out Nico Dosenbach as he brings us up to speed on changes in the way we are thinking about the somato-cognitive action network (SCAN) functional connectivity to subcortex.

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