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Kiwook

@kim-lab.bsky.social

Studying heterogeneity,origin, and functions of murine mononuclear phagocytes (monocytes, macrophages and DCs) in health and inflammation

13 Posts79 Follower54 Folgt
Kiwook@kim-lab.bsky.social · 3mo ago

We are excited to share our new paper @jem.org. Salmonella-infected mice lacking mesentery-resident macrophages lead to excessive monocyte recuriment with heightened expression of inflammatory cytokines, resulting in accelerated systemic infection.

Journal of Experimental Medicine@jem.org · 3mo ago

New study from Jiseon Kim, Jinki Yeom, Ki-Wook Kim et al. found that mesenteric #macrophage-#monocyte interactions control the magnitude of gut-mesentery #inflammation and its progression to systemic infection following enteric pathogen infection. rupress.org/jem/article/...

Kiwook@kim-lab.bsky.social · 12mo ago

Congrats, @christophschneider.bsky.social and your team! It’s a beautiful and fantastic study! GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation | Science Immunology www.science.org/doi/10.1126/...

GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation

AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity.

science.org

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

Highlight of a study by Teruyuki Sano and team in @nature.com revealing potential mechanisms by which commensal-specific T cells can contribute to extraintestinal inflammation #immunosky #microsky #neurosky

Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry - Nature Reviews Immunology

White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.

nature.com

Kiwook@kim-lab.bsky.social · last yr.

Big congratulations, Teruyuki Sano and his team on their publication in @nature.com ! It was great to collaborate this wonderful study with his team. We continue to contribute more to science together, especallly in the field of immunology! www.nature.com/articles/s41...

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature

Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

nature.com

Kiwook@kim-lab.bsky.social · last yr.

It's a beatiful lymphatic work entitled "Increased CSF drainage by non-invasive manipulaton of cervical lymphatics" @nature.com Big congrats, Dr. Gou Young Koh and his team! www.nature.com/articles/s41...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature

The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

nature.com

Immunity@cp-immunity.bsky.social · last yr.

Online now: A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses

A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses

Severe pneumonia is predominantly caused by cytokine storms in the lung, but how this process is controlled remains unclear. Li et al. find that severe pneumonia activates central amygdala GABAergic neurons, which triggers a sympathetic nerve-pulmonary interstitial macrophage interaction that amplifies lung inflammation. Blocking this pathway reduces harmful inflammation and cytokine storms, offering a promising therapeutic target for severe pneumonia.

dlvr.it

Bryan Yipp@bryanyipp.bsky.social · last yr.

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social www.cell.com/immunity/abs...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

cell.com

Dimitrios Davalos & Lab@davalos.bsky.social · last yr.

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

cell.com

Calum Bain@bainlab.bsky.social · last yr.

🚨 Dedicated BSky account for EMDS2025 launched Please share far and wide. Follow @emds2025.bsky.social for all updates on the EMDS2025: Scotland Edition We have an amazing line up of speakers and are excited to welcome all of you to bonnie Scotland in September! @britsocimm.bsky.social

@emds2025.bsky.social · last yr.

Welcome to the BSky account for EMDS2025. Please follow us to hear about updates & deadlines for EMDS2025: Scotland Edition. Check out www.emds2025.com for full details - registration will open soon. We look forward to welcoming you all to the wonderful city of Edinburgh in September.

Kiwook@kim-lab.bsky.social · last yr.

Three monocyte-derived Microglia/BAM papers in Immunity(@cp-immunity.bsky.social) plus one cell reports paper! Congrats for all authors and Dr. Steffen Jung (@steffenjung.bsky.social)! cell.com/immunity/ful... cell.com/immunity/ful... cell.com/immunity/ful... plus www.cell.com/cell-reports...

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

Brains of aging mice harbor rare monocyte-derived microglia (MoMg) that are transcriptomically indistinguishable from yolk-sac-derived cells. MoMg are targets of clonal hematopoiesis (CH) and, hence, ...

cell.com

Kiwook@kim-lab.bsky.social · last yr.

Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you! www.cell.com/immunity/ful...

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis

Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

cell.com