Plasticity in #CellCellCommunication may be central for how cell fate is robustly established in complex patterned tissues doi.org/10.1038/s415... @ksusztak.bsky.social #SingleCellRNASequencing #SpatialTranscriptomics #KidneyDevelopment

Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions - Nature Genetics

The spatial organization of human kidney development is explored using single-cell RNA sequencing and spatial transcriptomics, highlighting the crucial role of microenvironmental signals in guiding ce...

doi.org

Mediators of cell fate decisions in human fetal kidney development identified using spatial transcriptomics @natgenet.nature.com @ksusztak.bsky.social @pennmedicine.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

Kidney biopsies in adults with diabetes are generally safe, and using smaller-diameter needles, minimizing unnecessary trauma, and ensuring adequate operator experience may have a bigger impact than patient-related risk factors alone. kidney.pub/CJASN1083... #ASNCJASN @ksusztak.bsky.social

By summarizing these patterns in a tissue signature and a plasma panel, the researchers, @ksusztak.bsky.social et al, have improved detection and risk stratification compared to clinical models. 2/3

🚨CONGRATS @ksusztak.bsky.social @bernhard-dumoulin.bsky.social & team on a fantastic @nature.com paper! DKD isn’t 1 disease! #spatial & #singlecell data reveal distinct injury niches—including B cell–rich immune subtype linked to faster progression. #Nephrology #PrecisionMedicine #NephSky #MedSky 🧪

Immune microenvironments comprising aggregated B cells in a subset of individuals who have accelerated diabetic kidney disease progression @nature.com @ksusztak.bsky.social @upenn.edu www.nature.com/articles/d41... www.nature.com/articles/s41...

Nine-protein #APOL1 #ProteomicRiskScore (#APRS) predicting composite outcome of ≥40% #eGFRdecline, #KidneyFailure or death to bridge gap between #GeneticSusceptibility & clinical translation www.nature.com/articles/s41... @ksusztak.bsky.social #TranslationalScience

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes - Nature Medicine

For individuals with APOL1 high-risk genotypes, which are enriched in individuals of African ancestry, a nine-protein proteomic risk score enables early prediction of kidney disease progression and ma...

nature.com

Join us and @ksusztak.bsky.social TOMORROW for our Ivanovich Lectureship!

NU Dept. of Medicine@nuintmed.bsky.social · 6mo ago

Please join us on Mar. 18th for our next #MedicalGrandRounds we will be joined by @ksusztak.bsky.social from the University of Pennsylvania for our Ivanovich Lectureship!

This #ASNJASN study explored how enalapril, a common RAAS inhibitor used for kidney protection, affects different cell types in the kidney, particularly focusing on the distal nephron. Read more: kidney.pub/JASN0995 #BasicResearch Katalin Susztak Michael S. Balzer

Excited to share our recent JASN paper on enalapril effects in #DKD using #single-cell approaches.🧪 Thanks to the whole team @nephrointberlin.bsky.social @PennKidney, and @Bayer. Special 🙏 to my mentor @ksusztak.bsky.social. Her insightful X thread is copied below. 🔗 t.ly/oNjkJ #NephSky #MedSky

Defining the role of #ApolipoproteinL1 (#APOL1) #RiskVariants on #BloodPressure www.ahajournals.org/doi/10.1161/... @ksusztak.bsky.social‬ #HealthEquity #KidneyHealth #TranslationalScience

Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage | Circulation

BACKGROUND: Black people bear a disproportionate burden of hypertension and hypertension-attributed chronic kidney disease. A role of apolipoprotein L1 (APOL1) risk variants (RVs; G1 and G2) in these ...

ahajournals.org

Katalin Susztak accepting the Homer W. Smith Award. #KidneyWk

👏Huge congratulations to my fantastic mentor @ksusztak.bsky.social for receiving the 2025 ASN Homer Smith award.

Nephrology Times@nephtimes.bsky.social · 10mo ago

Katalin Susztak accepting the Homer W. Smith Award. #KidneyWk

Super-proud of my amazing wife @ksusztak.bsky.social, a real trailblazer scientist, a newly-elected member of the National Academy of Medicine, and the recipient of the Homer W Smith award from the American Society of Nephrology. It was great celebrating with you in Houston at #KidneyWk.

Congratulations @ksusztak.bsky.social and Gerd Blobel (not on Bluesky)!!!

Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/news-and-ins...

nam.edu

The opening plenary at #KidneyWk looks phenomenal Renal RCT Renaissance is upon us (LBCT list drops tomorrow) www.asn-online.org/education/ki...

We are delighted that our external advisory board member @ksusztak.bsky.social will be receiving this year’s Homer Smith Award at Kidney Week 2025. www.kidneynews.org/view/journal... Congratulations Katalin, so well deserved! 👏👏💐

👏 Congratulations to Katalin Susztak, MD, PhD, recipient of the 2026 David M. Hume Memorial Award! Learn more ➡️ bit.ly/47Taye5 We look forward to celebrating our award winners at SCM26 #NKFClinicals. Stay tuned for registration opening October 2025. @ksusztak.bsky.social

Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism www.nature.com/articles/s41... @ksusztak.bsky.social‬ #TranslationalScience

The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine

Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.

nature.com

🔥 Huge congrats to @ksusztak.bsky.social & team on a landmark @natgenet.nature.com paper! 🚶‍♂️🐁🐀Cross-species 🫘kidney pathway dysregulation via #singlecell functional profiling of individual samples — opening new therapeutic avenues. 🔗 www.nature.com/articles/s41... 🧪 #NephSky #MedSky

After random seating permutations and precise “single-human” clustering, here the ASN young investigator, mid career, and Homer Smith awards … of course with the queen in the middle ❤️ @asnkidney.bsky.social @ksusztak.bsky.social @rkramann.bsky.social @isgd.bsky.social #podocyteconference

First Emerging Career premeeting keynote from @ksusztak.bsky.social on “Mapping to Mechanism to Medicine” Kidney Disease Genetic Scorecard tool: susztaklab.com/GWAS2M/

New integrated approach identified candidate genes with diabetes-specific effects on kidney function, advancing the understanding of DKD pathophysiology. https://bit.ly/JASN0718 #ASNJASN #BasicResearch #GeneticResearch @ksusztak.bsky.social